化疗药物配制指南.doc

化疗药配备
Common Antineoplastic Drug Pharmacy Preparation Chart
Generic Name
(INN)
Trade Name
Concentration /
Diluent
Precautions /
Stock Solution
Stability
Vehicle for
Infusion
Precautions /
Ready-to-Use
Solution
Stability
Amifostine
Ethyol
500 mg in 9.7
mL of 0.9% NaCl
6 hrs (RT)
24 hrs
(refrigerated)
n.r.
Administer
within 25 minutes
Asparaginase
Asparaginase
10,000 U in 4
mL of WFI
In the dark,
6 hrs)
5% Dex / 0.9% NaCl

Azathioprine
Imurek
50 mg in 5-15
mL of WFI
120 hrs (RT
or refrigerated)
0.9% NaCl or 0.18% NaCl + 4% Dex
Administer after preparation
Bleomycin
Bleomycin

Numerous incompatibilities
0.9% NaCl

Carboplatin
Carboplat
50 mg in 5 mL
In the dark
5% Dex / 0.9% NaCl Conc > 0.5 mg/mL
8 hrs (RT) 24 hrs (refrigerated)
Carmustine
(BCNU)
Carmubris
Dissolve in 3 mL of ethanol, add 27 mL of WFI100 mg in 30 mL
5% Dex / 0.9% NaCl
0.9% NaCl
8 hrs (RT)
24 hrs (refrigerated)
Cisplatin
Platinex
50 mg in 100 mL
In the dark, RT
0.9% NaCl
8 hrs (RT)
Cladribine
Leustatin
10 mg in 10 mL

0.9% NaCl
Administer within < 8 hrs (refrigerated)
Cyclophosphamide
Endoxan
1,000 mg in 50 mL of WFI
24 hrs (refrigerated)
5% Dex / 0.9% NaCl

Cytarabine
Alexan
100 mg in 5 mL

5% Dex / 0.9% NaCl

Dacarbazine
(DTIC)
Detimedac
100 mg in 10 mL of WFI
In the dark; prepare immediately before use
5% Dex / 0.9% NaCl
Administer within < 30 min
Dactinomycin
Lyovac-
Cosmogen
Dissolve in 1.1 mL of WFI 0.5 mg in 1 mL
In the dark
5% Dex / 0.9% NaCl

Daunorubicin
Daunoblastin
100 mg in 10 mL of WFI
In the dark, 24 hrs (RT), 48 hrs (refrigerated)

Docetaxel
Taxotere
80 mg in 8 mL
Prepare immediately before use
5% Dex / 0.9% NaCl Conc < 0.74 mg/mL
4 hrs (RT)
Doxorubicin
(Adriamycin)
Adriblastin
50 mg in 25 mL
In the dark, refrigerated
N/A, bolus
Inject within 10-15 min
Epirubicin
Farmorubicin
50 mg in 25 mL
In the dark, refrigerated
N/A, bolus
Inject within 10-15 min
Estramustine
Phosphate
Estracyt
300 mg in 8 mL of WFI
Prepare immediately before use
5% Dex NO NaCl!
12 hrs (RT)24 hrs (refrigerated)
Etoposide
Vepesid J
100 mg in 5 mL

5% Dex / 0.9%
24 hrs at 0.4
Etoposide
Phosphate
Etopophos
100 mg of [etoposide] in 10 mL of WFI, 5% Dex , or 0.9% NaCl
Administer after preparation
5% Dex / 0.9% NaCl Conc > 0.1 mg/mL
Administer after preparation
Filgrastim
(G-CSF)
Neupogen
300 µg in 1 mL
Refrigerated
5% Dex. NO NaCl Conc > 2 µg/mL
24 hrs (refrigerated)
Fludarabine
Fludara
50 mg in 2 mL of WFI
8 hrs
5% Dex / 0.9% NaCl

Fluorouracil
(5-FU)
Fluroblastin
1,000 mg in 20 mL
In the dark, RT
5% Dex

Folinic Acid
Calcium Salt
Pentahydrate
Leucovorin
200 mg in 20 mL
In the dark
0.9% NaCl

Gemcitabine
Gemzar
200 mg in 5 mL of [NaCl]
24 hrs (RT);
DO NOT REFRIGERATE
0.9% NaCl
Administer within 30 min
Idarubicin
Zavedos
10 mg in 10 mL of WFI
24 hrs (refrigerated)
N/A, bolus
Inject within 10-15 min
Ifosfamide
Holoxan
1,000 mg in 25 mL of WFI
48 hrs (refrigerated)
5% Dex / 0.9% NaCl

Interferon
alfa-2a
Roferon A
3,000,000 U in 1 mL
In the dark, refrigerated
N/A
SC or IM
Interleukin-2
Proleukin
Dissolve in 1.2 mL of WFI18,000,000 U in 1 mL
24 hrs
5% Dex + 0.1% HA
Administer after preparation
m-AMSA
Amsidyl
1.5 mL of concentrate in 13.5 mL of soln (glass syringe) 75 mg in 15 mL
In the dark, 8 hrs
5% Dex NO NaCl!
Administer within 60-90 min
Melphalan
Alkeran
50 mg in 10 mL of [solution / diluent]
In the dark, RT; prepare immediate-ly before use
0.9% NaCl. No Dex!
Administer within < 90 min
Methotrexate
Methotrexate
50 mg in 2 mL
In the dark
5% Dex / 0.9% NaCl

Mitomycin C
Mitomycin
10 mg in 10 mL of WFI
In the dark; prepare immediately before use
5% Dex / 0.9% NaCl
3 hrs in 5% Dex
Mitoxantrone
Novantrone,
Onkotrone
20 mg in 10 mL
7 days once opened
5% Dex / 0.9% NaCl
48 hrs
Nimustine
ACNU
50 mg in 10 mL of WFI
Prepare immediately before use
N/A
Inject IV after preparation
Paclitaxel
Taxol
30 mg in 5 mL
In the dark, RT
5% Dex / 0.9% NaCl Conc 0.3-1.2 mg/mL
27 hrs (RT);
DO NOT REFRIGERATE!
USE PVC-FREE GIVING SETS!
Pentostatin
Nipent
10 mg in 5 mL of WFI
8 hrs (RT)
n.r.
Administer IV or diluted within 20-30 min
Teniposide
VM 26
50 mg in 5 mL
In the dark
5% Dex / 0.9% NaCl Conc 0.1 mg/mL
24 hrs (RT);
O NOT REFRIGERATE!
USE PVC-FREE GIVING SETS!
Thiotepa
Thiotepa
15 mg in 1.5 mL of WFI
Refrigerate; prepare immediately before use
5% Dex / 0.9% NaCl

Topotecan
Hycamtin
4 mg in 4 mL of WFI
12 hrs (RT),
24 hrs (refrigerated)
5% Dex / 0.9% NaCl Conc 25-50 µg/mL

Treosulfan
Ovastat
1,000 mg in 20 mL of WFI
8 hrs
n.r.

Vinblastine
Velbe
10 mg in 10 mL of NaCl
Prepare immediately before use
N/A
Inject IV within < 1 min
Vincristine
Vincristine
1 mg in 1 mL
In the dark, 14 days (refrigerated)
5% Dex / 0.9% NaCl

Vindesine
Eldisine
5 mg in 5 mL
30 days
(refrigerated)
N/A
Inject IV
Vinorelbine
Navelbine
10 mg in 1 mL of WFI

5% Dex / 0.9% NaCl
Administer within 6-10 min / 24 hrs (RT)
Abbreviations: WFI = Water for Injection; HA = Human Albumin; RT = Room Temperature; 5% Dex = 5% Dextrose Injection;
0.9% NaCl = 0.9% Sodium Chloride Injection

Source: Deutsche Fachinformationen, BPI Service GmbH, 98/3