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1、化疗药配备 Common Antineoplastic Drug Pharmacy Preparation Chart Generic Name (INN) Trade Name Concentration / Diluent Precautions / Stock Solution Stability Vehicle for Infusion Precautions / Ready-to-Use Solution Stability Amifostine Ethyol 500 mg in 9.7 mL of 0.9% NaCl 6 hrs (RT)
2、 24 hrs (refrigerated) n.r. Administer within 25 minutes Asparaginase Asparaginase 10,000 U in 4 mL of WFI In the dark, 6 hrs) 5% Dex / 0.9% NaCl Azathioprine Imurek 50 mg in 5-15 mL of WFI 120 hrs (RT or refrigerated) 0.9% NaCl or 0.18% NaCl + 4% Dex Administer after preparati
3、on Bleomycin Bleomycin Numerous incompatibilities 0.9% NaCl Carboplatin Carboplat 50 mg in 5 mL In the dark 5% Dex / 0.9% NaCl Conc > 0.5 mg/mL 8 hrs (RT) 24 hrs (refrigerated) Carmustine (BCNU) Carmubris Dissolve in 3 mL of ethanol, add 27 mL of WFI100 mg in 30 mL 5% Dex / 0.9%
4、 NaCl 0.9% NaCl 8 hrs (RT) 24 hrs (refrigerated) Cisplatin Platinex 50 mg in 100 mL In the dark, RT 0.9% NaCl 8 hrs (RT) Cladribine Leustatin 10 mg in 10 mL 0.9% NaCl Administer within < 8 hrs (refrigerated) Cyclophosphamide Endoxan 1,000 mg in 50 mL of WFI 24 hrs (refrigerated)
5、 5% Dex / 0.9% NaCl Cytarabine Alexan 100 mg in 5 mL 5% Dex / 0.9% NaCl Dacarbazine (DTIC) Detimedac 100 mg in 10 mL of WFI In the dark; prepare immediately before use 5% Dex / 0.9% NaCl Administer within < 30 min Dactinomycin Lyovac- Cosmogen Dissolve in 1.1 mL of WFI 0.5 m
6、g in 1 mL In the dark 5% Dex / 0.9% NaCl Daunorubicin Daunoblastin 100 mg in 10 mL of WFI In the dark, 24 hrs (RT), 48 hrs (refrigerated) Docetaxel Taxotere 80 mg in 8 mL Prepare immediately before use 5% Dex / 0.9% NaCl Conc < 0.74 mg/mL 4 hrs (RT) Doxorubicin (Adriamycin) A
7、driblastin 50 mg in 25 mL In the dark, refrigerated N/A, bolus Inject within 10-15 min Epirubicin Farmorubicin 50 mg in 25 mL In the dark, refrigerated N/A, bolus Inject within 10-15 min Estramustine Phosphate Estracyt 300 mg in 8 mL of WFI Prepare immediately before use 5% Dex NO Na
8、Cl! 12 hrs (RT)24 hrs (refrigerated) Etoposide Vepesid J 100 mg in 5 mL 5% Dex / 0.9% 24 hrs at 0.4 Etoposide Phosphate Etopophos 100 mg of [etoposide] in 10 mL of WFI, 5% Dex , or 0.9% NaCl Administer after preparation 5% Dex / 0.9% NaCl Conc > 0.1 mg/mL Administer after preparation
9、 Filgrastim (G-CSF) Neupogen 300 µg in 1 mL Refrigerated 5% Dex. NO NaCl Conc > 2 µg/mL 24 hrs (refrigerated) Fludarabine Fludara 50 mg in 2 mL of WFI 8 hrs 5% Dex / 0.9% NaCl Fluorouracil (5-FU) Fluroblastin 1,000 mg in 20 mL In the dark, RT 5% Dex Folinic Acid Calcium Sal
10、t Pentahydrate Leucovorin 200 mg in 20 mL In the dark 0.9% NaCl Gemcitabine Gemzar 200 mg in 5 mL of [NaCl] 24 hrs (RT); DO NOT REFRIGERATE 0.9% NaCl Administer within 30 min Idarubicin Zavedos 10 mg in 10 mL of WFI 24 hrs (refrigerated) N/A, bolus Inject within 10-15 min Ifosf
11、amide Holoxan 1,000 mg in 25 mL of WFI 48 hrs (refrigerated) 5% Dex / 0.9% NaCl Interferon alfa-2a Roferon A 3,000,000 U in 1 mL In the dark, refrigerated N/A SC or IM Interleukin-2 Proleukin Dissolve in 1.2 mL of WFI18,000,000 U in 1 mL 24 hrs 5% Dex + 0.1% HA Administer after p
12、reparation m-AMSA Amsidyl 1.5 mL of concentrate in 13.5 mL of soln (glass syringe) 75 mg in 15 mL In the dark, 8 hrs 5% Dex NO NaCl! Administer within 60-90 min Melphalan Alkeran 50 mg in 10 mL of [solution / diluent] In the dark, RT; prepare immediate-ly before use 0.9% NaCl. No Dex! Ad
13、minister within < 90 min Methotrexate Methotrexate 50 mg in 2 mL In the dark 5% Dex / 0.9% NaCl Mitomycin C Mitomycin 10 mg in 10 mL of WFI In the dark; prepare immediately before use 5% Dex / 0.9% NaCl 3 hrs in 5% Dex Mitoxantrone Novantrone, Onkotrone 20 mg in 10 mL 7 days once
14、opened 5% Dex / 0.9% NaCl 48 hrs Nimustine ACNU 50 mg in 10 mL of WFI Prepare immediately before use N/A Inject IV after preparation Paclitaxel Taxol 30 mg in 5 mL In the dark, RT 5% Dex / 0.9% NaCl Conc 0.3-1.2 mg/mL 27 hrs (RT); DO NOT REFRIGERATE! USE PVC-FREE GIVING SETS! Pentos
15、tatin Nipent 10 mg in 5 mL of WFI 8 hrs (RT) n.r. Administer IV or diluted within 20-30 min Teniposide VM 26 50 mg in 5 mL In the dark 5% Dex / 0.9% NaCl Conc 0.1 mg/mL 24 hrs (RT); O NOT REFRIGERATE! USE PVC-FREE GIVING SETS! Thiotepa Thiotepa 15 mg in 1.5 mL of WFI Refrigerate; pr
16、epare immediately before use 5% Dex / 0.9% NaCl Topotecan Hycamtin 4 mg in 4 mL of WFI 12 hrs (RT), 24 hrs (refrigerated) 5% Dex / 0.9% NaCl Conc 25-50 µg/mL Treosulfan Ovastat 1,000 mg in 20 mL of WFI 8 hrs n.r. Vinblastine Velbe 10 mg in 10 mL of NaCl Prepare immediately b
17、efore use N/A Inject IV within < 1 min Vincristine Vincristine 1 mg in 1 mL In the dark, 14 days (refrigerated) 5% Dex / 0.9% NaCl Vindesine Eldisine 5 mg in 5 mL 30 days (refrigerated) N/A Inject IV Vinorelbine Navelbine 10 mg in 1 mL of WFI 5% Dex / 0.9% NaCl Administer within 6-10 min / 24 hrs (RT) Abbreviations: WFI = Water for Injection; HA = Human Albumin; RT = Room Temperature; 5% Dex = 5% Dextrose Injection; 0.9% NaCl = 0.9% Sodium Chloride Injection Source: Deutsche Fachinformationen, BPI Service GmbH, 98/3
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