学术讨论—肝细胞癌中表达-南京医科大学综述.ppt

The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcinoma徐徐 智智南京医科大学附属南京第一医院暨南京医科大学附属南京第一医院暨南京市第一医院南京市第一医院 肿瘤肿瘤(zhngli)内科内科1第一页，共十四页。Worldwide incidence of HCCBlum HE,Spangenberg HC.Arch Iran Med.2007 Jul;10(3):361-71.第二页，共十四页。Identification of Yes-associated Protein(YAP)Zender,L.et al.Cell 125,1253-67EFGH第三页，共十四页。YAP improves cell proliferationTime(Days)*：p0.05。第四页，共十四页。YAP induces anchorage-independent growthMIHA-YAP cells but not MIHA-Vec could form colonies in soft-agar.第五页，共十四页。MIHA-YAP cells gained advantages in cell migration and invasion.YAP enhances cellular mobility and invasiveness第六页，共十四页。IHC results of YAP in HCC53.7%HCC samples showed nuclear YAP positive.第七页，共十四页。Clinical association of nuclear YAP in HCC第八页，共十四页。Clinical association of nuclear YAP and HCC-specific postsurgical recurrenceKaplan-Meier Median RFT：Nuclear YAP negative:25.8 months vs.Nuclear YAP positive：12.9 months第九页，共十四页。Nuclear YAP is an independent prognostic marker for HCC recurrenceCox Regression 第十页，共十四页。SummaryYAP confers tumorigenic and metastatic potentials in hepatocytes,as evidenced by enhanced aptitudes in cell viability,anchorage-independent growth,migration and invasion.YAP nuclear accumulation was found in the 53.7%of HCC,correlated with poorer tumor differentiation and higher serum alpha-fetoprotein(AFP)levels.Nuclear YAP is an independent predictor for HCC-specific recurrence-free survival.YAP plays an important role in HCC development and progression.第十一页，共十四页。Acknowledgement新加坡国立大学外科系和药学系新加坡国立大学外科系和药学系 Asso.Prof.John M.Luk香港大学外科系香港大学外科系 Prof.Fan S.T.，Prof.Poon R.T.and Surgical Tissue Bank南京市第一医院肿瘤南京市第一医院肿瘤(zhngli)内科内科 第十二页，共十四页。第十三页，共十四页。内容(nirng)总结The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcinoma。Identification of Yes-associated Protein(YAP)。Zender,L.et al.Cell 125,1253-67。Thank You第十四页，共十四页。