原发性高血压患者静息心率与高敏C反应蛋白、内皮素、靶器官损害的研究的论文.docx

原发性高血压患者静息心率与高敏C反应蛋白、内皮素、靶器官损害的研究的论文

原发性高血压患者静息心率与高敏C反应蛋白、内皮素、靶器官损害的研究的论文

Abstract

Objective: To investigate the relationship between resting heart rate (RHR) and high-sensitivity C-reactive protein (hs-CRP), endothelin (ET), and target organ damage in patients with primary hypertension.

Methods: A total of 168 patients with primary hypertension were enrolled in this cross-sectional study. RHR was measured by electrocardiogram, and hs-CRP and ET were measured by enzyme-linked immunosorbent assay. Target organ damage was assessed by echocardiography, carotid intima-media thickness, and estimated glomerular filtration rate.

Results: The mean RHR was 72.5±9.8 beats/min, and the mean hs-CRP and ET levels were 3.8±3.7 mg/L and 3.1±1.8 pg/mL, respectively. RHR was positively correlated with hs-CRP (r=0.309, P<0.001) and ET (r=0.283, P<0.001). After adjusting for potential confounding factors, RHR remained independently associated with hs-CRP (β=0.239, P=0.002) and ET (β=0.176, P=0.027). Furthermore, RHR was positively correlated with left ventricular mass index (r=0.277, P<0.001) and carotid intima-media thickness (r=0.245, P=0.002), but not with estimated glomerular filtration rate.

Conclusion: RHR is positively correlated with hs-CRP, ET, left ventricular mass index, and carotid intima-media thickness in patients with primary hypertension. These findings suggest that RHR may be a useful marker for identifying patients with hypertension who are at increased risk of target organ damage.

Keywords: resting heart rate, high-sensitivity C-reactive protein, endothelin, target organ damage, hypertension

摘要

目的：探讨静息心率（RHR）与高敏C反应蛋白（hs-CRP）、内皮素（ET）及靶器官损害在原发性高血压患者中的关系。

方法：本横断面研究纳入168例原发性高血压患者。使用心电图测量RHR，采用酶联免疫吸附法测量hs-CRP和ET。采用超声心动图、颈动脉内膜-中膜厚度和估测肾小球滤过率评估靶器官损害。

结果：平均RHR为72.5±9.8次/分钟，平均hs-CRP和ET水平分别为3.8±3.7 mg/L和3.1±1.8 pg/mL。RHR与hs-CRP（r=0.309，P<0.001）和ET（r=0.283，P<0.001）呈正相关。在调整潜在混杂因素后，RHR仍独立与hs-CRP（β=0.239，P=0.002）和ET（β=0.176，P=0.027）相关。此外，RHR与左心室质量指数（r=0.277，P<0.001）和颈动脉内膜-中膜厚度（r=0.245，P=0.002）呈正相关，但与估测肾小球滤过率无相关性。

结论：RHR与hs-CRP、ET、左心室质量指数和颈动脉内膜-中膜厚度呈正相关。这些发现表明，RHR可能是鉴别高血压患者靶器官损害风险增加的有用标志物。

关键词：静息心率，高敏C反应蛋白，内皮素，靶器官损害，高血压