英文引言.pptx

BiochemistryIntroduction 第1页/共10页What is Biochemistry?Describe structure,organization,function of cells in molecular terms.Structural Chemistry Metabolism Molecular Genetics第2页/共10页Biochemistry as a DisciplineBiochemistry as a Chemical ScienceAmino acidsSugarsLipidsNucleotidesVitaminsHormones第3页/共10页Chemical Elements of Living Matter第4页/共10页Monomers/Polymers Sugar/PolysaccharideNucleotide/Nucleic AcidsAmino acid/Polypeptides第5页/共10页Biochemistry as a Biological ScienceDistinguishing Characteristics of Living MatterConstant renewal of a highly ordered structure accompanied by an increase in complexity of that structureOvercoming entropy requires energyLife is self-replicating第6页/共10页Range of sizes of objects studied by biochemists and biologists第7页/共10页Uses of BiochemistryAgriculture:Herbicides and pesticidesMedicine:Monocloning antibodiesNutrition:VitaminesClinical Chemistry:transaminases and bilirubin/Liver disease Pharmacology:penicillin(inhibiting an enzyme that synthesizes an essential polysaccharide of the bacterial cell wall)Toxicology:第8页/共10页designer drugsIf the target site for action of a drug is a protein enzyme or receptor,determining the detailed molecular structure of that target allows us to design inhibitors that bind to it with great selectivity.AZT was the first drug approved in the United States for the treatment of HIV infections.This nucleoside is anabolized to the corresponding 5 triphosphate,which acts as an inhibitor of viral reverse transcriptase in making DNA from the viral RNA第9页/共10页End第10页/共10页