信号通路模式图素材.ppt

U1U2U5U4U6U1IntronExon 1Exon 2Protein complexes in RNA splicingExon 1Exon 2U2U5U6U2U5U6.WntG1SG2MActivating mutation in cancerInactivating mutation in cancerCell CycleControlApoptosisApaf1CARDApaf1CARDApaf1CARDCasp 9Casp 9Casp 9CCCCommon Alterations in Breast Cancer(ER-)Invasion&MetastasisRasPTENRasIncreased expression(no known mutation)p21Decreased expression(No known mutation)ProliferationHER2ERK1/2Grb2SosRafMEK1/2p53PTENPI3KSurvivalApoptosisDNA Repairp21ELK1AP1cMycPI 4,5 P2PI 3,4,5 P3BRCA1/2RasCyclinD1-CateninE-CadherinMTA3Mi-2HDAC1SnailMTA1Histone acetylation andgene expression.G1SG2MActivating mutation in cancerInactivating mutation in cancerCell CycleControlApoptosisApaf1CARDApaf1CARDApaf1CARDCasp 9Casp 9Casp 9CCCCommon Alterations in Breast Cancer(ER+)Invasion&MetastasisRasPTENRasIncreased expression(no known directmutation)p21Decreased expression(No known directmutation)Proliferationp53PTENPI3KSurvivalApoptosisp21ELK1AP1cMycPI 4,5 P2PI 3,4,5 P3CyclinD1K-RasERK1/2Grb2SosRafMEK1/2EGFRuPARER.IntronExon 1Exon 2Steps in RNA splicingExcision,Lariat formationExcision,TransesterificationExon 1Exon 2.GATCCTAGATTAGCCGGCCGGCCGGCATTAATTAATTACTGACTGA.