交大科学家讲科研系列讲座.ppt

Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,Preparing a successful career path:Differences between academic and industrial scientists,选择最佳事业发展道路：学术界与生物医药工业界科学家的区别,Bai Lu,Ph.D.,鲁 白,GlaxoSmithKline,R&D China,中国葛兰索史克研发部,鲁白博客：,Hedgehog Concept,孔子,Choose a job you love,and you will never have to work a day in your life,从事你喜欢的工作，就没有一天让你觉得是在工作,知之者不如好之者，好之者不如乐之者。,论语,雍也,做你喜欢的事,The goal of undergraduate/graduate education,Discover your true passion/interests,Understand your characters,On the look out for emerging fields,Develop your skills/capacities,Shirley Tighman,发现自己的性格特点,兴,趣和,长处,学术生涯,Academic career,Be your own boss,No schedule,Travel around the world,Meet interesting people,Pursue your interests,Career,Job,Dream jobs:pursue your interests,Publications vs.Drug Approvals in Neuroscience,SOURCE:1.PUBMED SEARCH:(1990Publication Date:2009Publication Date)AND(neuroscience)AND(HumansMesh)AND(Englishlang).,2.New Neurology Drug Approvals from CenterWatch,2009.,Overview of pharmaceutical/biotech industry,Poor understanding of,disease,biology,Poor predictable value of animal,models,Difficulty in delivering drugs across,BBB,High attrition rate mostly due to safety,Lengthy and large clinical trials,Year,FDA,Approvals,NS Approvals Novel NCE,2007 57,5 1,2008 53 6 3,2009 90 10 0,A,(53%),Tau(14%),Others,(22%),ACh(10%),Over 50%of drugs fail because of safety issues,5 phase III&3 phase II trials failed A,reduction achieved but no efficacy,On average,a new drug takes 10 years and$1 billion to develop,A good drug will have$1 billion/year revenue and about 8 years patent life,Drug development process,Drug discovery,pipeline,Repositioning assets for,ND Indications,Internal Programs,Academic,Partnerships,Business Development,Innovation to reduce attrition:,multiple checkpoints,Target Attrition,Molecular Attrition,Products of Value,Discovery,Candidate,Selection,Clinical,Development,Identification&Validation,of novel drugable target,Stem,cell,Novel targets,TIP,activity,Novel targets,Phenotypic screen,Novel targets,Human,neuron,BBB,Program,CNS delivery,TCM program,Chemical diversity,Human cell,Tox,Clinical Attrition,Expt.medicine,Mechanistic readout,(imaging,biomarkers),Target Selection,Candidate,FTIH/Phase I,PoC/Phase II,Pivotal/Phase III,Safety,PK,n=50,6 months,Safety,early,efficacy signs,n=500,1.5 years,Efficacy,Safety,n=2,000,2 3 years,IND,NDA,Academia vs Industry:,Output,Important and significant,Creative and novel,Solid and,rigorous,Unique,is essential,语不惊人誓不休,Academia,Papers,Safety,Efficacy,Market,Industry,Products,病人就是上帝,Academia vs Industry:,Styles,hypothesis driven,beginning review,freedom,competition,Academia,Independence,Mission oriented,End review,Discipline,Collaboration,Industry,Team work,Academia vs Industry:,Focus,curiosity to discovery,mechanism,creativity,Academia,To tell a story,Materialize ideas,Effect,Rigor,Industry,To make go-nogo,decision,Academia vs Industry:,people relationships,professor,instructors,students,Academia,postdocs,Pyramid,Less restrictive,Manage up,Industry,Matrix,Dynamic and interactive,Changes all the time,Making CNS drugs:,The devil is in the details,Dose response,Expression/distribution,Pharmacokinetics(PK),Pharmacodynamics,target engagement,Brain penetrate?,Toxicity,Interpersonal skills people assets,Interpersonal,relationships,team work,coordination,considerate of others needs/feelings,power of persuasion,win-win,Conflict resolution,debate,negotiation,mediation,People management,motivation,feedback,Crisis management,termination,sudden events,骤然临之而不慌,无故加之而不怒,Communication skills,写与说的技能,monthly reports,project summaries,meeting memos,email communications,Your first impression accounts 80%!,Think of it as a performance,Demonstrate your confidence,Take home message,One-on-one,Group,Critical,path R&D,的指南针,1,.,in vitro,receptor binding assay,3,.,cell based functional assay,ELT,HTS,2,.,cell based signaling assay,Focused,library,degenerative,disease models,(,AD model,),Candidate Selection,rat PK,acute injury models,(,Stroke model,),Safety Assessment,in vivo,models for neuroprotection,Timeline,R&D,的时间表,1,assay,2,assay,3,assay,QC of selective hits,Compound correlations,Compound synthesis,Chemistry+DMPK,Tests in,2,3,assays,Efficacy,ex vivo,Efficacy,in vivo,Complete in 7 months,Continue till Q2 next year,Q1 Q2 Q3 Q4,MarAprMayJunJulAugSepOctNovDec,Hit to Lead,Three teams working coordinately,SAR,SoC,HTS,animal model characterization,Biomarker,development,Project management R&D,项目进展的关键,Plan,action items,timelines,deliverables,C,oordinate multiple departments,Accountability,Ability to adapt to changes,constant reviews/report,rapidly changing projects,IP,BD,Safety,P,DMPK,Chemistry,Legal,external,Comparison:academic versus industry careers,Academia,Industry,Output,papers,products,Relationships,pyramid,matrix,Styles,Independence,Hypothesis driven,Beginning review,Freedom,Competition,Teamwork,Mission oriented,End review,Discipline,collaboration,Focus,Tell a story,Curiosity,Discovery,Mechanism,creativity,Go-Nogo,decision,Materialize ideas,Development,Effect,Rigor,Talent,Technical gift,Deep insights,Interpersonal skills,communication,Project choice,Logical analysis,Imagination,Critical path,Project management,Impact,Intellectual life,Physical life,What an ideal Ph.D.looks like?,Knowledge,special,know something of everything,broad,know everything of something,Techniques and ability to acquire techniques,Sense,critical and appreciative,Design,conduct,complete and analysis,Presentation,oral,written,Some key discoveries,Broaden expertise,Creativity,Initiative,Start,completion,Presentation skills,Independence,Growth,potential,What an ideal postdoc looks like?,Knowledgeable,Strong technical skills,Critical thinking,Discipline,Alignment,Communication skills,Interpersonal skills,Withstand pressure and changes,