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Oncogene PNAS 1. NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis Duke University Medical Center(杜克大学)7.0 E-mail: mari.shinohara@duke.edu. 2. NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitis St. Jude Children’s Research Hospital Email: thirumala-devi.kanneganti@stjude.org 3.Critical role for calcium mobilization in activation of the NLRP3 inflammasome Tiffany Horng , Harvard School of Public Health E-mail: thorng@hsph.harvard.edu 4. IL-1 Coordinates the Neutrophil Response to C. albicans in the Oral Mucosa(PLOS PATHOG) University of Zürich(苏黎世大学) Salomé LeibundGut-Landmann * Salome.leibundgut-landmann@uzh.ch 5. Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death University of Pennsylvania School of Veterinary Medicine(宾夕法尼亚大学兽医学院)7.0 Igor E. Brodsky * ibrodsky@vet.upenn.edu 6. Bacterial Manipulation of NK Cell Regulatory Activity Increases Susceptibility to Listeria monocytogenes Infection University Of Colorado School Of Medicine(科罗拉多大学医学院)USA 6.5 Laurel L. Lenz * laurel.lenz@ucdenver.edu 7. Histone H2B-IFI16 Recognition of Nuclear Herpesviral Genome Induces Cytoplasmic Interferon-尾 Responses Chicago Medical School(芝加哥) Bala Chandran * bala.chandran@rosalindfranklin.edu 8. Molecular Basis of Acute Cystitis Reveals SusceptibilityGenes and Immunotherapeutic Targets Lund University(瑞典隆德大学)瑞典 Catharina Svanborg * catharina.svanborg@med.lu.se 9. Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B cell lymphoma/leukemia 10 (Bcl10) During T Cell receptor and Oncogenic Caspase Recruitment Domain-Containing Protein 11 (CARD11) Signaling The Johns Hopkins University School of Medicine(约翰·霍普金斯大学)USA Joel L. Pomerantz Email: joel.pomerantz@jhmi.edu 10. Immunomodulatory and anti-inflammatory activity in vitro and in vivo of a novel antimicrobial candidate University of Siena锡耶纳大学ITALY Alessandro Pini E-mail: pinia@unisi.it 11.Mesenchymal Stromal Cell Derived Extracellular Vesicles Promote Myeloid Biased Multipotent Hematopoietic Progenitor Expansion via Toll-Like Receptor Engagement Oregon State University(美国俄勒冈州立大学)6.5 Peter Kurre Email: kurrepe@ohsu.edu 12. Identification of Nexinhibs, small-molecule inhibitors of neutrophil exocytosis and inflammation. Druggability of the small GTPase Rab27a The Scripps Research Institute(斯克里普斯研究所-加利福尼亚) Sergio D. Catz1 Email: scatz@scripps.edu 13.Lipid Cell Signaling, Enzymes, LIPID MAPS, and Mediators of Inflammation university of california at san diego加州大学圣地亚哥分校7.0 Edward A. Dennis Email: edennis@ucsd.edu 14. A Group A Streptococcus ADP-Ribosyltransferase Toxin Stimulates a Protective Interleukin 1β-Dependent Macrophage Immune Response Hal M. Hoffman University of California Email:vnizet@ucsd.edu. 15.Reduction of Streptococcus pneumoniae Colonization and Dissemination by a Nonopsonic Capsular Polysaccharide Antibody Albert Einstein College of Medicine and Montefiore Medical Center艾伯特爱因斯坦学院 Email:l.pirofski@einstein.yu.edu. 16. Bone Marrow Dendritic Cells from Mice with an Altered Microbiota Provide Interleukin 17A-Dependent Protection against Entamoeba histolytica Colitis University of Virginia Health System(弗吉尼亚医护大学)7.0 William A. Petri, Jr Email:wap3g@cms.mail.virginia.edu 17. Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation University of Sheffield Medical School, Sheffield (英国谢菲尔德大学医学院) David H. Dockrell, Email: d.h.dockrell@sheffield.ac.uk 18. Klebsiella pneumoniae Siderophores Induce Inflammation, Bacterial Dissemination, and HIF-1 Stabilization during Pneumonia University of Michigan(密歇根大学)6.5 Michael A. Bachman, Email: mikebach@med.umich.edu. 19. Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures University of Maryland(马里兰大学美国)7.0 Najib M. El-Sayed, Email: elsayed@umd.edu 20. Toll-Like Receptor 3/TRIF-Dependent IL-12p70 Secretion Mediated by Streptococcus pneumoniae RNA and Its Priming by Influenza A Virus Coinfection in Human Dendritic Cells Karolinska University Hospital(卡罗林斯卡大学医院)瑞典 Birgitta Henriques-Normark, Email: birgitta.henriques@ki.se 21. Lambda Interferon Restructures the Nasal Microbiome and Increases Susceptibility to Staphylococcus aureus Superinfection Columbia University(哥伦比亚大学)7.0 Alice S. Prince, Email: asp7@columbia.edu. 22. Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4- Mediated Linear-Ubiquitin-Chain Formation University of Southern California南加州大学7.0 Jae U. Jung, Email: jaeujung@med.usc.edu. (CELL HOST & MICROBE) 23. Cell-Cycle Regulators and Cell Death in Immunity Duke University7.0 Xinnian Dong Email: xdong@duke.edu 24. Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra University of Perugia(佩鲁贾大学-意大利) Luigina Romani Email: luigina.romani@unipg.it (Cell reports) 25. A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection Duke University *Correspondence: douglas.golenbock@umassmed.edu 26. Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis Medical University Innsbruck(奥地利) Corresponding author: andreas.villunger@i-med.ac.at (Genes & Development) 27. DUSP11 activity on triphosphorylated transcripts promotes Argonaute association with noncanonical viral microRNAs and regulates steady-state levels of cellular noncoding RNAs The University of Texas at Austin, Austin得克萨斯大学奥斯汀分校6.5 Corresponding author: chris_sullivan@austin.utexas.edu 28. RIP3: a molecular switch for necrosis and inflammation University of Massachusetts Medical School(麻省医学院) Francis Ka-Ming Chan E-mail francis.chan@umassmed.edu 29. Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer Stanford University School of Medicine(斯坦福)7.5 Corresponding authors: julsage@stanford.edu, ogozani@stanford.edu(nature communication) 30. PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation University of Pittsburgh(匹兹堡大学)usa lizhicao@) or to J.J. (email: jiangjx@) or to D.T. (email: tangd2@upmc.edu 31. CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages University of Cambridge 32. IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis University of Perugia(佩鲁贾大学) italy email: luigina.romani@unipg.it 33. Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP Case Western Reserve University6.5 email: eric.pearlman@uci.edu 34. Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes The University of Manchester(英国玛斯特6.0) Email: alessandra_mortellaro@immunol.a-star.edu.sg 35. Bacterial Exotoxins and the Inflammasome National institutes of health(USA) 36. Mahtab Moayeri Email: mmoayeri@niaid.nih.gov (journal of immunology) 37. Dichotomy between T Cell and B Cell Tolerance to Neonatal Retroviral Infection Permits T Cell Therapy Imperial College London伦敦帝国学院 E-mail address: george.kassiotis@crick.ac.uk 38. Helicobacter pylori–Induced IL-1b Secretion in Innate Immune Cells Is Regulated by the NLRP3 Inflammasome and Requires the Cag Pathogenicity Island Technische Universita¨t M€unchen(germany) . E-mail address: markus. gerhard@tum.de 39. Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux University of Michigan(密西根)6.5 E-mail addresses: luigif@umich.edu (L.F.) and gabriel.nunez@umich.edu (G.N.) 40. Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling University of Mancheste(英国曼斯特大学)6.0 E-mail addresses: pablo.pelegrin@ffis.es (P.P.) and fatima.martin@ffis.es (F.M.-S.) 41. Neutrophil IL-1b Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+ Efflux Case Western Reserve University(西储大学,美国;)6.5 E-mail address: eric.pearlman@case.edu 42. Extracorporeal Photopheresis Promotes IL-1b Production Justus-Liebig– University Giessen(吉森大学德国) E-mail address: Holger.Hackstein@immunologie.med.uni-giessen.de 43. K+ Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+ Signaling Case Western Reserve University(西储大学,美国;)6.5 E-mail address: george.dubyak@case. edu 44. A Critical Role for Dendritic Cells in the Evolution of IL-1b–Mediated Murine Airway Disease University of California E-mail address: stephen.nishimura@ucsf.edu 44.Ex Vivo and In Vitro Effect of Serum Amyloid A in the Induction of Macrophage M2 Markers and Efferocytosis of Apoptotic Neutrophil伊利诺伊大学(英语:University of Illinois)7.0 45.Critical Role for IL-18 in Spontaneous Lung Inflammation Caused by Autophagy Deficiency Baylor College of Medicine贝勒医学院,休斯敦 . E-mail address: teissa@bcm.edu 46. Hypoxia/Reoxygenation Inhibits P2Y11 Receptor Expression and Its Immunosuppressive Activity in Human Dendritic Cells Universite´ Franc¸oisRabelais de Tours法国图尔大学 E-mail: denis.angoulvant@ univ-tours.fr 47.Bacterial RNA: An Underestimated Stimulus for Innate Immune Responses University Hospital Heidelberg海德堡大学医院 E-mail address: tatjana. eigenbrod@med.uni-heidelberg.de 48. Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10–Dependent Mechanism University of British Columbia不列颠哥伦比亚大学; E-mail address: mlevings@mail.ubc.ca 49. Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells new york university school of medicine 美国纽约大学医学院7.5 . E-mail address: feskes01@nyumc.org 50. Bacterial Membrane Vesicles Mediate the Release of Mycobacterium tuberculosis Lipoglycans and Lipoproteins from Infected Macrophages Case Western Reserve University6.5 E-mail address: paw28@case.edu 51. Multiple Cathepsins Promote Pro–IL-1b Synthesis and NLRP3-Mediated IL-1b Activation University of Massachusetts Medical School马萨诸塞大学医学院; 麻省大学医学院; 麻州大学医学院; E-mail address: Kenneth.Rock@ umassmed.edu 52. Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice 昆士兰大学(The University of Queensland)澳大利亚6.5 E-mail addresses: katryn.stacey@uq. edu.au (K.J.S.) and d.sester@uq.edu.au (D.P.S.) 53. Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1b Release Justus-Liebig-University Giessen(germany) E-mail address: Veronika.Grau@chiru.med.uni-giessen.de 54. The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice 麦吉尔大学(McGill University)加拿大6.5 E-mail address: maya.saleh@mcgill.ca 55. MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus 宾夕法尼亚大学(University of Pennsylvania )7.0 Address correspondence to Susan R. Weiss, weisssr@upenn.edu. 56. Response of Mammalian Macrophages to Challenge with the Chlorovirus Acanthocystis turfacea Chlorella Virus 1 内布拉斯加大学林肯分校-University of Nebraska-Lincoln6.5 Address correspondence to Thomas M. Petro, tpetro@unmc.edu, or David D. Dunigan, ddunigan2@unl.edu. 57. Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1 Production upon Extrinsic Stimulation in Culture medical college of wisconsin威斯康星医学院 USA Address correspondence to Laurie T. Krug, laurie.krug@stonybrook.edu 58. Suppressor of Cytokine Signaling 3 Is an Inducible Host Factor That Regulates Virus Egress during Ebola Virus Infection University of Washington华盛顿大学 Address correspondence to Michael G. Katze, honey@uw.edu. 59. Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background Helmholtz Centre for Infection Research, Braunschweig, Germany University of Tennessee Health Science Center田纳西大学 Address correspondence to Klaus Schughart, klaus.schughart@helmholtz-hzi.de. 60. Partial Attenuation of Respiratory Syncytial Virus with a Deletion of a Small Hydrophobic Gene Is Associated with Elevated Interleukin-1 Responses Imperial College London帝国理工学院 Address correspondence to John S. Tregoning, john.tregoning@imperial.ac.uk
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