血液灌流联合血液透析对急性肾衰竭患者外周血IL-1β、SAA、IL-10的影响的论文.docx

血液灌流联合血液透析对急性肾衰竭患者外周血IL-1β、SAA、IL-10的影响的论文

血液灌流联合血液透析对急性肾衰竭患者外周血IL-1β、SAA、IL-10的影响的论文

摘要：

目的：探讨血液灌流联合血液透析对急性肾衰竭患者外周血IL-1β、SAA、IL-10的影响。

方法：选择40例急性肾衰竭患者作为研究对象，随机分为观察组和对照组各20例。对照组采用常规血液透析治疗，观察组在常规血液透析基础上加用血液灌流治疗。比较两组治疗前后外周血IL-1β、SAA、IL-10水平的变化。

结果：治疗后，两组患者的外周血IL-1β、SAA水平均明显下降，IL-10水平明显升高，且观察组的下降和升高程度均显著高于对照组，差异有统计学意义（P<0.05）。

结论：血液灌流联合血液透析治疗能够显著改善急性肾衰竭患者的炎症反应和免疫功能，具有较好的临床应用前景。

关键词：血液灌流；血液透析；急性肾衰竭；IL-1β；SAA；IL-10

Abstract：

Objective: To investigate the effect of blood perfusion combined with blood dialysis on peripheral blood IL-1β, SAA and IL-10 in patients with acute renal failure.

Methods: Forty patients with acute renal failure were randomly divided into observation group and control group, with 20 cases in each group. The control group was treated with conventional blood dialysis, and the observation group was treated with blood perfusion on the basis of conventional blood dialysis. The changes of peripheral blood IL-1β, SAA and IL-10 levels before and after treatment were compared between the two groups.

Results: After treatment, the peripheral blood IL-1β and SAA levels of both groups of patients decreased significantly, and the IL-10 level increased significantly, and the degree of decrease and increase in the observation group was significantly higher than that in the control group, with statistical significance (P<0.05).

Conclusion: Blood perfusion combined with blood dialysis can significantly improve the inflammatory response and immune function of patients with acute renal failure, and has good clinical application prospects.

Keywords: blood perfusion; blood dialysis; acute renal failure; IL-1β; SAA; IL-10.