急性肾炎专题知识讲座.pptx

Acute Glomerulonephritis急性肾炎专题知识讲座第1页Edema 急性肾炎专题知识讲座第2页Hematuria急性肾炎专题知识讲座第3页HypertensionConvulsion Anti o C3 proteinuria 急性肾炎专题知识讲座第4页This glomerulus is hypercellular and capillary loops are poorly defined.This is a type of proliferative glomerulonephritis急性肾炎专题知识讲座第5页the immune deposits are distributed in the capillary loops in a granular,bumpy pattern because of the focal nature of the deposition process急性肾炎专题知识讲座第6页Diagonosis?Why?edema proteinuriaHematuriahypertension.急性肾炎专题知识讲座第7页Acute Glomerulonephritis Background Causes PathophysiologyClinical manifestationDiagonosisDifferetional diagonosisTratmentprogonosis急性肾炎专题知识讲座第8页BackgroundAtypical onsetedema hematuria proteinuria hypertension Persistently depressed C3(past 8-10 wk)急性肾炎专题知识讲座第9页急性肾炎专题知识讲座第10页Pathophysiology and Clinical manifestation急性肾炎专题知识讲座第11页streptococcal antigens specific antibodies activate the complement system c3 急性肾炎专题知识讲座第12页急性肾炎专题知识讲座第13页Various cytokines other cellular immunity factors glomerular basement membrane blood efusion Hematuria Proteinuria cast急性肾炎专题知识讲座第14页急性肾炎专题知识讲座第15页 Various cytokines proliferation of mesangial and epithelial cells glomerular perfusion,glomerular filtrate(GF)-Severe oliguria,renal failure急性肾炎专题知识讲座第16页急性肾炎专题知识讲座第17页glomerular filtrate(GF)-H2O,Na+sterve -blood volume edema hypertention circulatory congestionencephalopathy.急性肾炎专题知识讲座第18页PathologyThe hypercellularity of post-streptococcal glomerulonephritis is due to increased numbers of epithelial,endothelial,and mesangial cells as well as neutrophils in and around the capillary loops.This disease may follow several weeks after infection with certain strains of group A beta hemolytic streptococci.急性肾炎专题知识讲座第19页Post-streptococcal glomerulonephritis is immunologically mediated,and the immune deposits are distributed in the capillary loops in a granular,bumpy pattern because of the focal nature of the deposition process.急性肾炎专题知识讲座第20页Clinical manifestion Sex Age HistoryGross hematuriaedema Hypertension 急性肾炎专题知识讲座第21页1 Circulatory congestion2 Hypertensive encephalopathy 3 Acute renal failure 急性肾炎专题知识讲座第22页