J.T.Baker英文资料—LCMS溶剂概述.pdf

PRODUCT LINE OVERVIEW|1ProductLineoverviewThe J.T.Baker high purity LC/MS solvents product line is designed to meet your needs in the rapidly growing applications of LC/UV and LC/MS.Avantor Performance Materials,Inc.manufactures high purity solvents that set the standard for accurate,reproducible,high resolution analytical separations.We combine our expertise in distillation,purification,quality control,analytic testing,and packaging to produce application optimized and function-tested solvents for LC/UV and LC/MS applications.These high quality solvents,in combination with innovative packaging options,ensure optimal instrument performance every time.ApplicAtions/techniquesJ.T.Baker LC/MS solvent blends are ideally suited for all LC/MS applications.ApplicationTechniquesPharmaceuticalBiopharmaceuticalDrugDiscoveryDrugMetabolitesDrugDegradationPurificationandIsolationManufacturingandQA/QCEnvironmentalEPAMethod535FoodandBeverageQA/QCLifeSciencesProteomicsMetabolomicsClinical/ForensicsToxicologyClinicalAssaystrends And chAllengesLC/MS instrumentation is the fastest growing segment in the analytical equipment industry.Recently developed methods in an expanding number of fields present many new challenges.Creation of a wide range of new variables to be managed and controlled.Methods requiring solvents suitable for LC/MS use.Methods demanding interference-free solvents and mobile phases.Todays ultra-sensitive instruments place a premium on the purity of solvents and mobile phases.Contaminants,such as polyethylene glycol,metal ions,phthalates,and amides cause unreliable results and create a tremendous amount of rework.Solvents are required to have low residue to prevent clogging.Use of low grade solvents often causes mixed signals in your results.LC/MS SolventsPRODUCT LINE OVERVIEW|2the J.t.BAKer AdvAntAge“ApplicAtion optimized,FunctionAlly tested”Application Optimized:Products are filtered through 0.2 m filters Solvents contain low particles Solvents contain low:PEG polyethylene glycol Phthalates Amides Solvents contain extremely low levels of:Metal ions Non-volatile residuesFunction Tested:Each lot tested for LC/MS Suitability,ESI+UV-Vis Absorbance Trace Metals Residue After Evaporation AssayuvgrAdient quAlityUV gradient is a critical parameter for successful LC applications.Avantor Performance Materials,Inc.utilizes the following testing procedures to ensure J.T.Baker LC/MS solvents exceed the American Chemical Societys,requirements for LC suitability:Gradient LC with UV detection sensitivity of moderate to sub ppb levels of impurities Multiple wavelengths to maximize sensitivity for different impurity classes Octadecyl columns for detection of non-polar impuritiessuitABle solventscriticAl For successLC/MS Suitability TestFunction tested LC/MS solvents illustrate interference-free baselines,ensuring LC/MS users can have the utmost confidence in J.T.Baker LC/MS solvent performance.The results demonstrate the suitability of each of these solvents:FiltrAtioncontrolling pArticlesSolvents with low particle counts are critical to obtaining maximum performance as todays instruments have increased sensitivity to particles and as the instrument/columns migrate to smaller dimensions.Our solvents are processed through the highest quality 0.2 m filters to remove particles and minimize residue after evaporation.Further,filtration is not recommended by the leading instrument companiesit often leads to contamination or the introduction of additional particles.Let J.T.Baker handle the filtration so you can spend more time taking accurate,reliable data measurements.reproduciBilityhigh quAlity delivered every timeOur solvents are closely monitored and tested for key contaminants to ensure they deliver the highest quality in every lot.We utilize numerous process controls and in-process monitoring to eliminate key contaminants.Key ContaminantsTests Performed PEGLC/MSSuitability,RAEPhthalatesLC/MSSuitability,andGradientLC-PDA,RAEMetalsLC/MSSuitability,TraceMetals,RAEOtherOrganicImpuritiesLC/MSSuitability,andGradientLC-PDA,RAEInorganicImpuritiesPerformanceTestingandRAEMailing Address:Avantor Performance Materials,Inc.222 Red School Lane Phillipsburg,NJ 08865On the Web:Our Web site features ASK AVANTOR,which includes live chat capabilities with customer service representatives.Ordering,Information and Assistance:Customer Service and Technical Servicetoll free:800-582-2537 or 908-859-2151fax:908-859-Lit#3082010 Avantor Performance Materials,Inc.All rights reserved.Trademarks are owned by Avantor Performance Materials,Inc.or its affiliates unless otherwise noted.About Avantor Performance Materials formerly Mallinckrodt BakerAvantor Performance Materials,formerly Mallinckrodt Baker,manufactures and markets high-performance chemistries and materials around the world under two well-known and respected brand names,J.T.Baker and Mallinckrodt Chemicals.These products are widely used in biotechnology and pharmaceutical production;in the manufacturing of semiconductors,flat panel displays and photovoltaic cells;and in research,academic and quality control laboratories.Based in Phillipsburg,New Jersey(USA),Avantor is owned by an affiliate of New Mountain Capital,LLC.For additional information please visit or follow LocationsPhillipsburg,NJ 9001:2008&14001:2004Paris,KY 9001:2008Mexico City,Mexico 9001:2008Deventer,Holland 9001:2008&14001:2004Selangor,Malaysia 9001:2008China:Avantor Performance Materials Trading(Shanghai)Co.,Ltd.Site A 14/F Xin Mei Union Square 999 Pudong South Road Pudong New Area Shanghai,200120 China Tel:[phone] Fax:[phone] E-mail:Europe:Avantor Performance Materials,B.V.Teugseweg 20,7418 AM Deventer,The Netherlands Tel:[phone] Fax:[phone] E-mail: India:Avantor Performance Materials Chemicals Private Ltd.425-426,Chintamani Plaza,Andheri Kurla Road Chakala,Andheri(East),Mumbai 400 099 Tel:[phone] Fax:[phone] E-mail:Malaysia:Avantor Performance Materials Sdn.Bhd.A-1201-2,12th Floor,Kelana Brem Tower 1,Jalan SS7/15(Jalan Stadium),Kelana Jaya 47301 Petaling Jaya,Selangor,Malaysia Tel:[phone] Fax:[phone] E-mail:Mexico:Avantor Performance Materials S.A.de C.V.Plomo 2 Fracc.Industrial Esfuerzo Nacional Xalostoc CP 55320 Ecatepec,Estado de Mexico,Mexico Tel:[phone] Fax:[phone] E-mail: North America:Avantor Performance Materials,Inc.222 Red School Lane Phillipsburg,NJ 08865 Tel:[phone] E-mail:Korea:Avantor Performance Materials International,Inc.Korea Branch8th Floor,Wooduck Building 832-2 Yeoksam 1-dong,Gangnam-gu Seoul,Korea,135-750 Tel:82-2-2052-0481 Fax:[phone] E-mail:trAce metAlsconsistent low levelsThe graph below indicates the historically low levels of trace metals of J.T.Baker LC/MS Acetonitrile.J.T.Baker LC/MS solvents deliver extremely low levels of trace metal impurities,and deliver this purity consistently from lot-to-lot,as shown in the table to the right over the course of two years.Product CodeDescriptionGrade9829AcetonitrileLC/MS9828EthylAcetateLC/MS9830MethanolLC/MS98272-PropanolLC/MS9831WaterLC/MSSolventsavailablein1L,4L,20L,andbulksizes.Pre-blendedsolventsarealsoavailable.