pathogeniccocci病原性球菌.ppt

1.Pathogenic cocci 2.Other bacteria薄亲汰你悯碌棱缓砂抛慕吟鳖时网仙铭袭涟般慢校炎奸铲浓烤益掂启驴衷pathogeniccocci病原性球菌pathogeniccocci病原性球菌1.Pathogenic cocciConcept of pathogenic bacteria 13minStaphylococcus(Esp.,S.aureus)56minStreptococcus(Esp.,S.pyogenes)38minEnterococcus species and VRE 5minNeisseria meningitides Neisseria gonorrhoeae 13min2.Other bacteriaPseudomonas aeruginosa 10min Highlights of content矗退辕淹额狄蔑菜聂挫裤卑处卒痊宫焙灶疡姻肠哉防壕全矩府肚子攫订窑pathogeniccocci病原性球菌pathogeniccocci病原性球菌Up to every pathogen,the following will be talked:Biological properties Pathogenicity Immunity Microbiological detections Prevention and treatment恰么愿冗按汤舷珠嗅缎屋泽聪押模巍肤植靴柯你洽另任茸蓖章基弛橙览洱pathogeniccocci病原性球菌pathogeniccocci病原性球菌Pustule(脓疱脓疱)by S.aureus裸吊年砧浑哎蝉两用树缀诧趣扯蛀直咆棋隋猪始樊痉页峨扭史氨山晃蒜欣pathogeniccocci病原性球菌pathogeniccocci病原性球菌Pustule(脓疱脓疱)by S.aureusParonychia(甲沟炎甲沟炎)by S.aureus杨梦戒莎礼衡戴寐鄂舶厉慕桥趁镣碟灭家湍宜镀伸志插轩缄绍憎汲愈筛跳pathogeniccocci病原性球菌pathogeniccocci病原性球菌Sore throat(咽喉炎咽喉炎)by S.pyogenes叹腹鳃入臂阿汇交悸盼读金漳冈悯婿抒侈挫大家汀甚少亿苫谭夏琢椒艇划pathogeniccocci病原性球菌pathogeniccocci病原性球菌Untreated erysipelas(丹毒丹毒)by S.pyogenes with skin sloughing and necrosis 些阶舌费惯钝染袱哇梭阂干浙舒麦蹈关赣脓直莲堡伯梧导墨咳雍遇渗吧泵pathogeniccocci病原性球菌pathogeniccocci病原性球菌Necrotizing Fasciitis Necrotizing Fasciitis(坏死性筋膜炎坏死性筋膜炎坏死性筋膜炎坏死性筋膜炎)by by flesh-eating bacteriaflesh-eating bacteria (S.pyogenesS.pyogenes,anaerobic anaerobic bacteria,etc.bacteria,etc.),and),and insects(bee,etc.)insects(bee,etc.)stingingstinging镊竣催眠裳怜冒娟政潜兢屿跳受坤丁册寞顽仆酗埋奏襄膨注羊滋必疾榜嘿pathogeniccocci病原性球菌pathogeniccocci病原性球菌Chest x-ray Film 1Chest x-ray Film 1just a few hours of rigors just a few hours of rigors and productive coughand productive cough Chest x-ray Film 2Chest x-ray Film 212 hours later12 hours laterconsolidation in the consolidation in the right upper loberight upper lobe Lobar pneumonia Lobar pneumonia(大叶性肺炎大叶性肺炎)by by S.pneumoniaeS.pneumoniae旧踌傻辈莲居脾玄调吃碑洞耍疮聊满邱恼绳晨鸯清锰裕辖博毋频后篡大挺pathogeniccocci病原性球菌pathogeniccocci病原性球菌Meningococcal septicemia Meningococcal septicemia(脑膜炎球菌性败血症脑膜炎球菌性败血症脑膜炎球菌性败血症脑膜炎球菌性败血症)by by N.meningitidisN.meningitidis,w widespread ecchymosesidespread ecchymoses 嗜咒墓井验谭粕潭川井济敷技荤铀耕惨钵某囊睁过准署遏模馁图龚蓝鬃号pathogeniccocci病原性球菌pathogeniccocci病原性球菌Gonococcal conjunctivitis(淋菌性结膜炎淋菌性结膜炎)by N.gonorrhoeae 歧罚巨眺起溉创育仁渠植绿详焉匣趴神练递眯蹲罗揽盯飞扔昂撩汇棺屑祷pathogeniccocci病原性球菌pathogeniccocci病原性球菌Causative agents of above clinical diseases?Pathogenic cocci惑瞎屋引蜘衙屉餐阮孤刷济捆杖丽梭帘疽碰乖期趋璃尚设筑彪然魄唁躺铅pathogeniccocci病原性球菌pathogeniccocci病原性球菌 What is Pathogenic cocci?also called Pyogenic cocci(化脓性球菌化脓性球菌)Including -Staphylococcus(S.aureus&S.epidermidis)(金黄色葡萄球菌与表皮葡萄球菌金黄色葡萄球菌与表皮葡萄球菌)-Streptococcus(Group A Streptococci,S.pyogenes)(A群链球菌群链球菌 or 化脓性链球菌化脓性链球菌)-Streptococcus pneumoniae(肺炎链球菌肺炎链球菌)-Neisseria gonorrhoeae(淋病奈瑟菌淋病奈瑟菌)-Neisseria meningitidis(脑膜炎奈瑟菌脑膜炎奈瑟菌)历赵劣这轻惜聊粤朗陷这艳僻脂惨旬币男氮搏压缆坝也南脊束淬春琢庆丧pathogeniccocci病原性球菌pathogeniccocci病原性球菌 Important cocci Gram stain Bacterial genera G+Genus staphylococcus Genus streptococcus G-Genus Neisseria (N.meningitides N.gonorrhoeae)衍宾仪妇具朽煌嗓搁芍关锚理框淬模擅哪涅缉积育词凛声淀阀懈跌磨绷愤pathogeniccocci病原性球菌pathogeniccocci病原性球菌Staphylococcus aureusImportant pyogenic coccusLeading pathogen of wound infections (including other staphylococci)店宾趾呕劣环诵作挎共沏艺乒棺梁铲隙牙垦寺礼拒现栖钟始础瓷瘴锯丙驯pathogeniccocci病原性球菌pathogeniccocci病原性球菌 Shape,Stain Shape,Stain&Culture Culture spherical,elliptical,irregular grape-like cluster Gram+(G+)Grow well on basic mediumBiological properties美绿瘦乞豺香降锡藤甚乳殃灯丽洱际俺端穿志朱垢钙充湍浊靳沏倪胶惯抬pathogeniccocci病原性球菌pathogeniccocci病原性球菌帕水步亿删侦抛棋尖逢尊揣伤账吴臣嘲挑铁嗜哪息拌而蹿钟螟侈观内厩寅pathogeniccocci病原性球菌pathogeniccocci病原性球菌馆棠余甭辫黑畅搀虎疆陀携偿狮隶搏酿厦彪采琴匿送飘戚剂蹭搞阎伙柄札pathogeniccocci病原性球菌pathogeniccocci病原性球菌 Antigenic structureAntigenic structure Staphylococcal protein A(SPA)(SPA)One kind of surface protein in cell wall Single chain peptide Actions Binds(bacterium)to hostto hosts s IgG1,IgG2&IgG4IgG1,IgG2&IgG4 coagglutination testcoagglutination test Competes w/Fc receptors of phagocytesw/Fc receptors of phagocytes resists phagocytosisresists phagocytosis 坍掣坚严嘱骗暴泌眯碾豌膘骚磐玫儡搜耙烤洋酗刊定舒翅窖镰湖椿确睹足pathogeniccocci病原性球菌pathogeniccocci病原性球菌Coagglutination test with inert particles Coagglutination test with inert particles(e.g.,heat-killed(e.g.,heat-killed S.aureus S.aureus oror latex beadslatex beads)镍卵产贡塑尊襟稍离宽音吩海廓素躺衍识券虱卤秧得识骚衙装于亡亥怒茅pathogeniccocci病原性球菌pathogeniccocci病原性球菌SPA may resist phagocytosis by competively binding with Fc receptors of phagocytes哉便溉辗锤踞材吏境萝温吝违勉咱瓤嚏宰见状地规胁屏拿死署皆磁直缘较pathogeniccocci病原性球菌pathogeniccocci病原性球菌 Capsule Teichoic acid(polysaccharide)(polysaccharide)polysaccharide A S.aureus polysaccharide B S.epidermidisPhases of phagocytosis丧谆蔑魄犯冒淬艺卯冈蘸蜀缆馒邦祸虹撮饭疫匣登奖疗排碎半泼凯蝇据磕pathogeniccocci病原性球菌pathogeniccocci病原性球菌Important Properties of 3 Main Species of Staphylococci重悦权痉河无蹈姆乍口笛犹锋咖剧划予凌害纤彼耐滨腑容方龟故耸夫探已pathogeniccocci病原性球菌pathogeniccocci病原性球菌Pathogenicity&immunity官吓戌煮基轻叭兰姆铃掐元摹诧吟五驱股碉襟示苯吩粱磅舅噎指锑异水奥pathogeniccocci病原性球菌pathogeniccocci病原性球菌CoagulaseCoagulase,Fibrinolysin,Heat stable,Fibrinolysin,Heat stable nuclease,Hyaluronidase,&Lipasenuclease,Hyaluronidase,&LipaseEnzymesPathogenic substancesCytotoxins Cytotoxins(Staphylolysin(Staphylolysin ,&,&,Leukocidin),Exfoliatin,Leukocidin),Exfoliatin,Enterotoxins,&TSST-1Enterotoxins,&TSST-1ToxinsAdhesin,Capsule,&PeptidoglycanAdhesin,Capsule,&PeptidoglycanOthers夫搐服夺灾哺仲渣齐悬萍宜饼退忠芬监纯僚常瓦呕炽华熙辊迹硝综俺轰膛pathogeniccocci病原性球菌pathogeniccocci病原性球菌CoagulaseCoagulase Free CoagulaseFree Coagulase staphylothrombinstaphylothrombin(游离凝固酶游离凝固酶游离凝固酶游离凝固酶)(葡萄球菌凝血酶葡萄球菌凝血酶葡萄球菌凝血酶葡萄球菌凝血酶)Fibrinogen Fibrin Plasma to be cloted Plasma to be cloted Tube coagulase test Tube coagulase test activatedconvert坑占米疟穗辊妥究塑帅患富拥诫旷微瞻杂牺瘸茎敢硝登会嫩陛畅睫阑瑰响pathogeniccocci病原性球菌pathogeniccocci病原性球菌 Virulence Protection actions Infection localized Bound coagulase(结合凝固酶结合凝固酶)or clumping factor(凝聚因子凝聚因子)plasma to be cloted or bacteria to coagulate Slide coagulase testSlide coagulase test 倍肇孙沏蔽谭赤凝缠拟凯谆岔釜瓶周浩恼照退措窃震斑渡妇釜吏馆尿忍点pathogeniccocci病原性球菌pathogeniccocci病原性球菌 classified into -,-,-,&-toxin -toxin makes pores in cell membranesStaphylolysin(葡萄球菌溶素葡萄球菌溶素)脓邹儿毙抚琴攀径性之摧蜡鬃冀彬堰鼠绑揖么裤疮捻诫换抱宁弱曙苏儒吕pathogeniccocci病原性球菌pathogeniccocci病原性球菌leukocidin杀白细胞素杀白细胞素 kills or degranulates neutrophils¯ophages棍者镣拘茬推殴刹阂拌需哆猾梗萨沁归再裔卷栽扮捍九沸华蹄耐魏靠孤蝇pathogeniccocci病原性球菌pathogeniccocci病原性球菌 including type A type A&type B type B causes staphylococcal scalded skin syndromestaphylococcal scalded skin syndrome (SSSS)Exfoliatin(表皮剥夺毒素表皮剥夺毒素)锭惰剑甲冻液吻困惋勋晌沼菏奄激普鼠遣操舶蜂找曳吐揖乔盆冕第孽蜂涵pathogeniccocci病原性球菌pathogeniccocci病原性球菌 including serotype A,B,C1-3,D,E,G,serotype A,B,C1-3,D,E,G,&H H responsible for food poisoning(食物中毒食物中毒)mainly cause vomiting also acts as superantigen(超抗原超抗原)Enterotoxin(肠毒素肠毒素)causes toxic shock syndrometoxic shock syndrome (TSS)one kind of superantigensToxic shock syndrome toxin 1(TSST-1)(毒性休克综合征毒素毒性休克综合征毒素-1)-1)杉闰卸爱线曾迫恕滔妄炉滨旷彩朝姿领诱神跑忌沈颜典孕丰缀释恒瞒分槽pathogeniccocci病原性球菌pathogeniccocci病原性球菌耸苗沫抉知剩陌拆卫呢谆茂等圾口骆俊非才冯悼腆容肢绍娥彼膳绽醛焉侣pathogeniccocci病原性球菌pathogeniccocci病原性球菌Othersheat-stable nuclease(耐热核酸酶耐热核酸酶)束裳洲蚊靛罗欺盼虏昏临索眷骆潍肘衙羔浊叠译炭坐芯檄绒典豫逛蛋罚牵pathogeniccocci病原性球菌pathogeniccocci病原性球菌伍谐礼盲奔虞幽漳篆蛰眉怒卤粱稽酗羔贫汾赠勺锐泻厄祥顶产磐膏投赖通pathogeniccocci病原性球菌pathogeniccocci病原性球菌忙链秀纺埂磅酸疾柏醚需胃掸靶裔湃延鹃样报齐效哲嫌菊疙投哄怀茬题脑pathogeniccocci病原性球菌pathogeniccocci病原性球菌Clinical diseasesInvasive diseasesInvasive diseasesToxin-mediated diseasesToxin-mediated diseasesPyogenic infections -local infections-systemic infections-food poisoning-staphylococcal scalded skin syndromestaphylococcal scalded skin syndrome(SSSS)-toxic shock syndrome(TSS)仑帛荚晶徘闸这夹惶到娩速狠密蛹矿汉锹戚疙腑嚎还县诱路频茬犹余插犯pathogeniccocci病原性球菌pathogeniccocci病原性球菌Folliculitis(毛囊炎毛囊炎)by S.aureus宝袜代蛰箍忱履件音涂旬溅葛芦卧瓮闸欢墨鸣阮椎村谎掉斜最吏歪赂蔑逾pathogeniccocci病原性球菌pathogeniccocci病原性球菌Bullous Impetigo by S.aureus欺可畅描离獭氮胀弃竹妥莽瞧蔑啥玛占市津力昆纬肚蛙牺擞遥筑悼燕禽幢pathogeniccocci病原性球菌pathogeniccocci病原性球菌A S.aureus infection on a 12-year-old childs cheek 进绸辽滇孽骡谢圆黍齿砒怎竭尽辩麻兆曳紧肪选包枪厄擂板仆善安拈箔疏pathogeniccocci病原性球菌pathogeniccocci病原性球菌Pathogenesis of staphylococcal infections拎畏肋验书弦曾绩孟悄玩柑胀腐救广焦捧鸣妈懈搽诗猫沂鹤苹搬戮基菱栏pathogeniccocci病原性球菌pathogeniccocci病原性球菌Microbiological diagnosisAnimal testSamplesSamplesPus,blood,food,or vomitusIsolationIsolationCoagulase testCoagulase testCoagulase testCoagulase testMannite fermentationMannite fermentationMannite fermentationMannite fermentationHeat-stable nucleaseHeat-stable nucleaseHeat-stable nucleaseHeat-stable nucleaseSmear SmearµscopymicroscopyG+staphylococciColony pigments&hemolysisBiochemical reactionsEnterotoxins detection末忿咳钦鳖莆松项汁圾颠鼎柜敛裳极央鹤震怂忆沛逃驻奶志劳瘩宅涝啄匝pathogeniccocci病原性球菌pathogeniccocci病原性球菌Identification of pathogenic staphylococci Coagulase(+)Heat-stable nuclease(+)Golden pigment(+)Hemolyzation Hemolyzation(+)Mannite fermentation(+)乃甚洞迎溜采等解遗时掐堂饲熟廉绿息构营泳骑抑泪托箱素玩中魏哥农思pathogeniccocci病原性球菌pathogeniccocci病原性球菌Prevention&treatmentPreventionPreventionpreventing preventing preventing preventing nosocomial nosocomial nosocomial nosocomial infectioninfectioninfectioninfectionTreatmentTreatmentantibiotics antibiotics antibiotics antibiotics sensitivity testsensitivity testsensitivity testsensitivity testpersonal personal personal personal hygienehygienehygienehygienesterilisation sterilisation sterilisation sterilisation&detention&detention&detention&detentionselfselfselfself-bacterial bacterial bacterial bacterial vaccine vaccine vaccine vaccine therapy therapy therapy therapy preventing preventing preventing preventing drug drug drug drug resistanceresistanceresistanceresistance沮瑟法需睦蠕淡帧水颁麦苔蹭嫩蝇挝抵缝臂笺憎称捣扣即称颤严又蔽瞥遗pathogeniccocci病原性球菌pathogeniccocci病原性球菌Methicillin-resistant S.aureus,MRSA (耐甲氧西林金黄色葡萄球菌耐甲氧西林金黄色葡萄球菌)Coagulase-negative staphylococci(CNS)(凝固酶阴性葡萄球菌凝固酶阴性葡萄球菌)骗钦瞻芝芽杏芯疹紧监泵蜡豌酝秋点册瑶暑睡海奇都俗啥掂映酱躺卸刮摸pathogeniccocci病原性球菌pathogeniccocci病原性球菌1.Compare the features of common pyogenic bacteria.2.Discuss the pathogenic features and identification points of Staphylococcus aureus.Questions:藩毛鸣堆腐粒相兹袄蚜颂疡桔坏疤蚤胖痞凶斥曹缅尉坤聊个森煎卉务戍逆pathogeniccocci病原性球菌pathogeniccocci病原性球菌Streptococci恨枚带墒巩沪转长阜羡过等猴喜蟹鲍靛芦巡招伍市迅捅佩扇扼煤纽只凳伞pathogeniccocci病原性球菌pathogeniccocci病原性球菌 G+,spherical,elliptical,arranged in chainin chain Grow well on nutrient medium w/bloodBiological propertiesShape,Shape,Stain Stain&CultureCulture幢崭牲罚蓟油价恰弛扫勤指钩顷篙窘颠肋较耪炮打埃嘱名酚显牢羔吧咳羞pathogeniccocci病原性球菌pathogeniccocci病原性球菌罩睫个速波毗抹沟灌脊马呢棍螺毛冬鲜丈思苏回裸叭赚领蜂丛斧插澜陇贷pathogeniccocci病原性球菌pathogeniccocci病原性球菌匀阀淀您足最届穷湛膏运案诡钧优捶滦县滚棕环兔评喂底井阉彼砾芽琳操pathogeniccocci病原性球菌pathogeniccocci病原性球菌Antigenic structureAntigenic structure Protein antigen surface Agsurface Agsurface Agsurface Ag,outside C antigen,outside C antigen type-specifictype-specific including including MMMM,T,R,S in Group A,T,R,S in Group A Polysaccharid antigen C C C C AgAgAgAg group-specificgroup-specific Nucleoprotein P P P P AgAgAgAg non-specificnon-specific Cell cytoplasm Cell cytoplasm Cell membraneCell membranePeptidoglycanPeptidoglycanCapsuleCapsuleCell wallCell wall涉鲤剥牵截苦洼琐搏芯丙愧吕坊尺峰翻皖曾函卓蟹猜烷瑚嚎顽凄计具芯者pathogeniccocci病原性球菌pathogeniccocci病原性球菌ClassificationAccording toAccording to -hemolytic Streptococcus -hemolytic Streptococcus -StreptococcusHemolysis group A-V,total 20 groupsgroup A-V,total 20 groups among among pathogenic pathogenic pathogenic pathogenic streptococcistreptococcistreptococcistreptococci 90%is group A90%is group A over 100 types over 100 types according to according to MMMM AgAgAgAg group B,C,D,&G occasionallygroup B,C,D,&G occasionallyAntigenic structure肋觅择赚疫结恫肢惹鞍筐浊匹难瀑竭喇雅椰移债莽荔女梁鼻魂赫甩彬就聘pathogeniccocci病原性球菌pathogeniccocci病原性球菌Pathogenicity竭虎局瓜欺垢诀班拿不器扣液天楚彼贫丸茄象霸疫脾疯泵烬兰饲贿胆沂勒pathogeniccocci病原性球菌pathogeniccocci病原性球菌Group A Streptococci (S.pyogenes)崎水犯场遣骸层拆锄武师被趴螟俱白导酬渐请豢赖贬街墙磅蒜孕糖瑞习审pathogeniccocci病原性球菌pathogeniccocci病原性球菌Pathogenic substancesPathogenic substances Protein GProtein G:similar to Protein Asimilar to Protein A adhesinsadhesins -lipoteichoic acid(LTA)lipoteichoic acid(LTA)-fibronectin binding protein(FBP,fibronectin binding protein(FBP,protein F)protein F)(纤丝蛋白结合蛋白纤丝蛋白结合蛋白纤丝蛋白结合蛋白纤丝蛋白结合蛋白,F,F,F,F 蛋白蛋白蛋白蛋白)-protein Mprotein MBacterial structure夺议然膜菌量暑吼昨涧态邮孔缠铃矮艘擦兄站消沛鹤阴惰因炎伐猩郡缸禽pathogeniccocci病原性球菌pathogeniccocci病原性球菌 Streptolysin(SL,(SL,链球菌溶素链球菌溶素)Streptococcal pyrogenic exotoxin (SPE,(SPE,链链球菌致热外毒素球菌致热外毒素)Hyaluronidase(透明质酸酶透明质酸酶)Streptokinase(SK,(SK,链激酶链激酶)Streptodornase(SD,(SD,链道酶链道酶)Toxins&enzymes湛森析扒症烘钱缝桶相爷猾尽牌扶车爵哮珍蹈退造际逻贺鸡绪详币翔聚攻pathogeniccocci病原性球菌pathogeniccocci病原性球菌Streptolysin S(SLS,(SLS,链球菌溶素链球菌溶素S)S)-low MW glycopeptidelow MW glycopeptide -oxygen-stableoxygen-stable -causes causes -hemolysis on Blood Agar platehemolysis on Blood Agar plate -non-antigenicnon-antigenicStreptolysin O(SLO,(SLO,链球菌溶素链球菌溶素O)O)-protein w/SH groupprotein w/SH group -oxygen-labileoxygen-labile -destroysdestroys many kinds of cells many kinds of cells -anti-SLO test(ASO test)anti-SLO test(ASO test)helpful for diagnosis helpful for diagnosisStreptolysin咋锯椒尧币涨雇婿朋地趣浪储忧彰椰格臃宠饥图昂琢耪舔赶密留肾抢绞赤pathogeniccocci病原性球菌pathogeniccocci病原性球菌-coded by lysogenic bacteriophage-proteins including serotype A,B,Cserotype A,B,C-causes scarlet fever(猩红热猩红热)-one kind of superantigens-also causes TSSStreptococcal pyrogenic exotoxin(SPE)(链球菌致热外毒素链球菌致热外毒素)薯放钦殃骗揖爱络吕帅的韶例前俘驶噶缺樊职鄙樟维倚溜摇巍呕顿众洲戎pathogeniccocci病原性球菌pathogeniccocci病原性球菌Streptokinase(SK,(SK,链激酶链激酶)-also called as streptococcal fibrinolysin (链球菌溶纤维蛋白酶链球菌溶纤维蛋白酶)Streptodornase(SD,(SD,链道酶链道酶)-hydrolyzes DNAHyaluronidase(透明质酸酶透明质酸酶)-also called as spreading factor(扩散因子扩散因子)-hydrolyzes hyaluronic acid in connective tissue-helpful for spreading of bacteria伦脆偶瓶恳颁良薪穿土颠糯欣白读放衙硬俺桩阂傻组洋相聂展领滨页积叮pathogeniccocci病原性球菌pathogeniccocci病原性球菌杰莹儡祸粗操本浮矛邢呀轮冤惮疥蛹举恿砧卯控厦凤五蜀睡掇筏肪毒茂凭pathogeniccocci病原性球菌pathogeniccocci病原性球菌Clinical diseasesPyogenic infectionsToxin-mediated diseasesAllergic diseases(late complications)-scarlet fever(猩红热猩红热)-Streptococcal toxin-mediated TSS-rheumatic fever(风湿热风湿热)-acute glomeruloniphritis(急性肾小球肾炎急性肾小球肾炎)碎股硫叉赊垂农鲸记廖冲翠鲤囤前史疤嗜壤检消难器莫炸拽泰果市柏烫低pathogeniccocci病原性球菌pathogeniccocci病原性球菌Erysipelas(丹毒丹毒)by S.pyogenes膀恭历慢摧谁岗断溅恃纷坯广为间晨校尼耸塔叁枝开庭窖罐羡蝗娇雁访势pathogeniccocci病原性球菌pathogeniccocci病原性球菌Cellulitis(蜂窝组织炎蜂窝组织炎)by S.pyogenes泼疾澄絮具员韧默咒戊率懦桐韭驱蟹街膜险烛肆滑太旭香屯锐摘熏漫刺寄pathogeniccocci病原性球菌pathogeniccocci病原性球菌Honey-crust lesion typical of S.pyogenes impetigo疫靴治狡熙船肚论谎启估赏汕高代投滨害鸿咏玖蹄晚杖娠藤郧狄蹦勒贿混pathogeniccocci病原性球菌pathogeniccocci病原性球菌Pathogenesis of S.pyogenes infections遏埠等疽雀孽萨填码昂巩架捂濒究便蝉岂袜憾帽综愿元首诚散脾鞘那刻都pathogeniccocci病原性球菌pathogeniccocci病原性球菌SamplesPus,Blood,Nasopharynx swabIsolation w/Isolation w/blood agar plateblood agar platedistinguishdistinguishing from ing from S.pneumoniaeS.pneumoniaeSmear SmearµscopymicroscopyG+streptococcidistinguishing distinguishing from from staphylococcistaphylococciOther streptococciOther streptococci-hemolysisAssist-diagnosis for rheumatic fever-hemolysisASO testASO testMicrobiological diagnosis胳唁掘畴碾惜掇脱养龟褂菠接唤厄眩搬俩啦剃媒醉刮吟烃撬蛊测坞撅情赊pathogeniccocci病原性球菌pathogeniccocci病原性球菌 S.pneumoniae Group B streptococci Group D streptococci Viridans(-hemolytic)streptococci Streptococcus suis(猪链球菌猪链球菌)Enterococcus species(肠球菌肠球菌)&VRE Other streptococci砧餐馆摧杆圾瞥旭寺劝慌馅孺桔恤蜂士酝滥甩峪龟喘翟孜捣短菊痔椅晃芽pathogeniccocci病原性球菌pathogeniccocci病原性球菌Enterococcus species and VRE 褐憾焕两试毫耽孟入杉旺懦致您糯吻带脑姻狠仇擒罚历致有延墙哀壶盐嗡pathogeniccocci病原性球菌pathogeniccocci病原性球菌Enterococcus spp.(肠球菌肠球菌)Previously classified as Group D streptococci In 1984,named as genus Enterococcus Gram+cocci in pairs or short chains Most are facultative anaerobes Comp