LCMS2010的维护与故障诊断.ppt

,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,SHIMADZU,LCMS2010,日常维护与故障诊断,1,LCMS2010,日常维护与故障诊断,LCMS2010,基本结构介绍,MS,日常维护,LCMS2010,故障诊断,2,LCMS2010,基本结构介绍,LC,Online Degasser+Pump+Autosampler+Column Oven+Detector,MS,Ion Source+Ion Optics+Mass filter+Detector,Vacuum,Controller,3,LCMS2010,基本结构介绍,-,MS,Turbo molecular pump 1,Turbo molecular pump 2,Rotary Pump,Drain,Detector,Quadrupole rod,Pre-rod,Entrance lens,Focus Lens,Octopole,Q-array,New Skimmer,Shutter,from LC,Block heater,ESI Probe,Source Window,CDL,Drying Gas,Angle Spray,4,MS,日常维护,5,MS,日常维护,Turbo molecular pump 1,Turbo molecular pump 2,Rotary Pump,Drain,Detector,Quadrupole rod,Pre-rod,Entrance lens,Focus Lens,Octopole,Q-array,Shutter,from LC,Block heater,ESI PIPE,APCI PIPE,Source Window,CDL,Angle Spray,LENS SYSTEM,VACUUM SYSTEM,6,MS,日常维护,ESI/APCI,源维护,清洗喷雾腔,清洗或更换,CDL,清洗,LENS SYSTEM,真空泵的维护,真空检查及其,IG,更换,7,MS,日常维护,离子源（,ESI,）,ESI,源 检查,ESI PIPE,是否需要更换或调整,一般,ESI,源压差为,8,MS,日常维护,离子源,(APCI),APCI,源 检查,APCI PIPE,是否需要更换或调整,检查,Corona Needle,是否需要清洗,处理方法：,一般污染，用丙酮擦拭,严重污染，砂纸打磨并用甲醇超声清洗,9,MS,日常维护,离子源,(APCI),拆卸,Corona Needle,后位置的调整,10,MS,日常维护,喷雾腔,清洗,：,一般污染，用甲醇或异丙醇擦拭,严重污染，砂纸打磨并用甲醇超声清洗,用甲醇或异丙醇擦拭,11,MS,日常维护,CDL,CDL,堵塞会严重影响仪器的灵敏度,方法：更换,CDL Unit,或,CDL Pipe,12,MS,日常维护,CDL,1,2,3,4,5,13,MS,日常维护,Q-Array,、,Octopole,、,Skimmer&Lens,Q-array Q-,阵列,八极杆透镜,Qctopole,四极杆,Quadrupole,Q-,阵列,侧面,八极杆透镜,四极杆侧面,14,MS,日常维护,Q-Array,、,Octopole,、,Skimmer&Lens,Q-Array,Octopole&Skimmer,Stack lens,注意：,skimmer,为整体，不能拆散。,15,MS,日常维护,真空系统,机械泵排除杂质,分析条件,排气频率,排气时间,ESI,1/Week,30min,APCI,1/Day,60min,机械泵换油（标准,3000,小时）,16,MS,日常维护,真空系统,不需要,BALLAST,17,MS,日常维护,真空检查,18,MS,日常维护,IG,更换,20000hours,更换，一般,2,年,19,MS,日常维护,定期维护表,项目,频率,清洗,Probe holder,每周（擦拭）,清洗,Heater Block,每月（超声清洗）,ESI,源维护,每月（更换,ESI PIPE,）,APCI corona needle,清洗,每月,APCI,源维护,每,6,月（更换,APCI pipe,及其,Corona Needle,）,清洗,Lens System,每,6,月,更换,CDL,每,6,月,更换泵油,每,4,月,更换,IG,2,年,其它项目：,RP,维护,/1.5,年；,TMP,维护,/3,年,MSNAVIGATOR,20,LCMS2010,故障诊断,联机故障,LC,连接方式,RS232,线,网线,（,CBM-20A,或者,CBM-20Alite,可使用初始化,）,MS,连接方式,SCSI,线,SCSI,设备只在电脑开机时候检测，,MS,必须先开。,21,LCMS2010,故障诊断,面板指示灯的含义,STATUS,红灯（,TMP,没有启动，关闭仪器后重新启动）,STATUS,红灯闪（真空度没有达到设定值）,仪器长期未运行，继续等待,真空泄漏，,Shutdown,后检查以下部件。,HEAT FLANGE,22,LCMS2010,故障诊断,提示,IG ERROR,（更换,IG,）,声音报警解析,间歇两声,CDL,HEAT BLOCK,APCI HEATER,过热保护,间歇三声,CDL,HEATBLOCK,APCI HEATER,加热装置或传感器异常,23,LCMS2010,故障诊断,HV,和温控不能开启,真空,Not Ready,Interlock,24,LCMS2010,故障诊断,低真空正常，高真空异常。,（高真空在长时间运行后仍然只能达到,10,3,次,shutter open,时候到达,10,2,）,Stack Lens,没有安装好，使高真空基本与低真空连通,25,LCMS2010,故障诊断,离子流弱或不稳定,源故障,ESI pipe,Pipe position,Probe position,Probe current,HV,APCI pipe,Corona Needle,Probe current,Heater and HV,CDL,、,Heater Block,故障,CDL,堵或污染，,CDL,加热，,Heater Block,污染,检测器故障,电压低，,EMP,老化,LENS,故障,Lens system contaminated,，,Skimmer,堵,软件原因,调谐文件，方法文件,高真空一直在,10,4,26,LCMS2010,故障诊断,背景高,污染,CDL,Heater Block,Probe,Probe Holder,LC system,Mobile phase,27,LCMS2010,故障诊断,宽峰,液相连接处死体积大,管径过大（自动进样器后建议使用小于,0.1mm ID,管路）,自动进样器污染,ESI,源位置不正确,温度太低,(Heater Block&CDL),28,LCMS2010,故障诊断,基线波动,气泡,CDL,Block,或,APCI,加热不稳,29,LCMS2010,故障诊断,调谐失败,调谐液过期或配置原因,仪器故障离子流强度低,气泡,30,LCMS2010,故障诊断,峰分叉,离子流强度大于,8X10,6,。（,降低检测器电压或者样品浓度,）,LC,系统死体积。,柱子原因。,31,THANK YOU,32,