骨肌系统疾病ppt课件.pptx

,#,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,Musculoskeletal Imaging,Bone lesions organized by cell of origin,A,natomy of the bone,Bone Lesions Organized by Cell of Origin(p367),Bony cortex,骨皮质,Medullary space,骨髓腔,Epiphysis,骨骺,Diaphysis,骨干,Epiphyseal plate,（骨骺板）,Metaphysis,干骺端,Terminology,Enostosis(bone island):,内生骨疣,Osteoma:,骨瘤,Melorheostosis:,肢骨纹状肥大,Osteoid osteoma:,骨样骨瘤,Osteoblastoma:,成骨细胞瘤,Osteosarcoma:,骨肉瘤,Synovial chondromatosis/osteochondromatosis:,滑膜骨软骨瘤,Enchondroma:,内生软骨瘤,Osteochondroma:,骨软骨瘤,Chondroblastoma:,软骨母细胞瘤,Chondromyxoid fibroma:,软骨黏液样纤维瘤,Chondrosarcoma:,软骨肉瘤,Bone Lesions Organized by Cell of Origin(p367),Terminology,Nonssifying fibroma/fibrous cortical defect:,纤维骨皮质缺损,Malignant fibrous histiocytoma:,恶性纤维组织细胞瘤,Fibrous dysplasia:,骨纤维异常增殖症,Hemangioma:,血管瘤,Angiosarcoma of bone:,血管肉瘤,Giant cell tumor(osteoclastoma):,巨细胞瘤,Eosinophilic granuloma(langehans cell histiocytosis):,嗜酸性肉芽肿,Ewing sarcoma:,尤文氏肉瘤,Multiple myeloma/plasmacytoma:,浆细胞瘤,Lymphoma:,淋巴瘤,Lipoma:,脂肪瘤,Liposarcoma:,脂肪肉瘤,Bone Lesions Organized by Cell of Origin(p367),Terminology,Chordoma:,脊索瘤,Simple bone cyst:,单纯性骨囊肿,Aneurysmal bone cyst:,动脉瘤样骨囊肿,Adamantinoma:,釉质瘤,Myositis ossificans:,骨化性肌炎,Brown tumor:,棕色瘤,Osteomyelitis:,骨髓炎,Bone Lesions Organized by Cell of Origin(p367),Contents,Bone Lesions Organized by Cell of Origin,Bone forming(Osteo-)lesion,Cartilage-forming(Chondro-)lesion,Lesions of fibrous origin,Lesions of vascular origin,Lesions of hematopoietic origin,Fat(Lipo-)lesions,Notochordal lesion,Lesions of unknown cell origin,Osseous metastasis,Benign tumor mimics,Bone Lesions Organized by Cell of Origin(p367),1.Bone forming(Osteo-)lesion,Benign and incidental:,Enostosis(bone island),内生骨疣,Osteoma,骨瘤,Melorheostosis,肢骨纹状肥大,Osteoid osteoma,骨样骨瘤,Osteoblastoma,成骨细胞瘤,Malignant:,Osteosarcoma,骨肉瘤,Bone Lesions Organized by Cell of Origin(p367),1.Bone forming(Osteo-)lesion:Enostosis(bone island),Benign and incidental finding,A small spiculated osteoblastic focus,小针状成骨细胞聚集,Differentiate from an osteoblastic metastasis,osteoid osteoma,or a low-grade osteosarcoma(if the lesson 2 cm),成骨性转移、骨样骨瘤或低级别骨肉瘤进行鉴别,Normal in bone scan,Osteopoikilosis is an autosomal dominant syndrome of multiple bone islands and keloid formation,全身脆性骨硬化表现为多发骨岛和瘢痕疙瘩，是一种常染色体显性综合征,Osteopathia striata is a benign,asymptomatic sclerotic dysplasia characterized by linear bands of sclerosis in the long bones and fan-like sclerosis in the flat pelvic bones,条纹性骨病是一种良性、无症状性硬化性发育不良，其特征为在长管状骨出现条纹状硬化，骨盆扁平骨呈扇形硬化,Bone Lesions Organized by Cell of Origin(p367),1.Bone forming(Osteo-)lesion:Osteoma,Benign and incidental,A slow-growing lesion,from the cortex of the skull or the frontal/ethmoid sinuses,Gardner syndrome is an autosomal dominant syndrome of multiple osteomas,intestinal polyposis,and soft-tissue desmoid tumors,Gardner,综合征是一种常染色体显性综合征，表现为多发骨瘤、肠息肉病和软组织韧带样纤维瘤,In contrast to a bone island,osteoma arises from the cortex rather than the medullary canal,相比较于骨岛起源于骨髓腔，骨瘤起源于骨皮质,Bone Lesions Organized by Cell of Origin(p367),1.Bone forming(Osteo-)lesion:Osteoma,Osteoma:Axial head CT in bone window shows a densely sclerotic osteoma arising from the cortex of the frontal sinus,Bone Lesions Organized by Cell of Origin(p367),1.Bone forming(Osteo-)lesion:Melorheostosis,Benign and incidental,肢骨纹状肥大,Non-neoplastic proliferation of thickened and irregular cortex with a typical candle-wax appearance,非新生物增生改变，表现为骨皮质增厚且不规则，呈蜡泪状改变,Pain,decreased range of motion,leg-bowing,leg-length discrepancy,Associated with scleroderma-like skin lesions over the affected region,肢骨纹状肥大可以伴随硬皮样皮肤病灶，皮肤病灶范围超过骨患病区域,Usually in a single lower limb(in the distribution of a single sclerotome).A sclerotome represents a zone supplied by a single sensory nerve,常见于单侧小腿，分布于单个生骨节。一个生骨节代表单一感觉神经供应的区域,Melorheostosis features intense uptake on bone scan,Bone Lesions Organized by Cell of Origin(p367),Melorheostosis:Frontal radiograph of the right tibia and fibula shows thickened,irregular wavy cortex of the medial tibia(arrow),Bone Lesions Organized by Cell of Origin(p367),1.Bone forming(Osteo-)lesion:Melorheostosis,1.Bone forming(Osteo-)lesion:Osteoid osteoma,Benign.The etiology:Inflammatory,vascular,and viral causes,The classic clinical presentation:night pain,relieved by aspirin in a teenager or young adult,11-30,岁,Location:the diaphyses of the leg long bones(femur and tibia)(most commonly);the posterior elements of the spine(about 20%),最好发于下肢长管状骨骨干（股骨和胫骨）。大约,20%,发生于脊柱后部。脊柱骨样骨瘤是导致疼痛性脊柱侧弯的重要原因。,Radiography and CT:a lucent nidus is surrounded by sclerosis,central calcification within the nidus,半透明的瘤巢伴周围环绕骨质硬化。瘤巢中央发生钙化,Bone scan:positive,with the double density sign representing intense uptake centrally in the region of the nidus and adjacent reactive uptake corresponding to sclerosis,MRI:the nidus is usually low-signal on T1WI and reactive marrow edema can obscure the lesion on T2WI,difficult to diagnosis in MRI,Bone Lesions Organized by Cell of Origin(p367),1.Bone forming(Osteo-)lesion:Osteoid osteoma,CT shows a radiolucent nidus in the left sacral ala(posterior element location)with a large central calcification(yellow arrows)with adjacent sclerosis(red arrows),The lesion is less conspicuous on MRI and has very low signal on the T1-weighted image(yellow arrow),The posterior bone scan shows increased radiotracer uptake(yellow arrow)of the nidus,with a double density sign (red arrow;corresponding to reactive sclerosis),Bone Lesions Organized by Cell of Origin(p367),Benign,approximately four times less common than osteoid osteoma,Histologically the same as an osteoid osteoma but is greater than 2 cm in size,组织学和骨样骨瘤类似，但是成骨细胞瘤大于,2cm,In the adolescent/young adult age range,Pain,not typically relieved by aspirin,The most common location:the posterior elements of the spine,the femur and tibia,The most common radiographic appearance:Lytic lesion with mineralization,With a large soft-tissue mass very rarely,no metastatic potential,成骨细胞瘤非常少见表现为侵袭性，伴软组织巨大肿块，但缺乏转移能力,Secondary aneurysmal bone cyst,especially lesion in spinal,可发生继发性动脉瘤样骨囊肿，尤其是位于脊柱,Bone Lesions Organized by Cell of Origin(p367),1.Bone forming(Osteo-)lesion:Osteosarcoma,1.Bone forming(Osteo-)lesion:Osteosarcoma,Malignant,Primary or secondary:Secondary osteosarcoma may arise from Paget disease(extremely aggressive)or after radiation,继发性骨肉瘤可以由,Paget,病或放疗后引起,Radiographic appearance:bony destruction,production of osteoid matrix,aggressive periosteal reaction,an associated soft-tissue mass,Early appearance:subtle sclerosis,Subtypes:more than 10 primary subtypes,the four most important subtypes,Conventional(most common),Telangiectatic,Parosteal(pronounced PAR-osteal),皮质旁型,Periosteal(pronounced PERI-osteal),骨膜型,Osteosarcoma may metastasize to lungs,where the metastases typically calcify,Bone Lesions Organized by Cell of Origin(p367),1.Bone forming(Osteo-)lesion:Conventional Osteosarcoma,Conventional(intramedullary)osteosarcoma:represents 75%of osteosarcomas and occurs in adolescents/young adults usually around the knee in the metaphysis of the femur or tibia,Conventional osteosarcoma:Radiograph(left image)shows a region of subtle heterogeneous sclerosis in the medial proximal tibial metaphysis(arrow).No periosteal reaction is apparent.T1-weighted MRI shows a well-defined region of marrow replacement by tumor(red arrows).T2-weighted MRI with fat suppression demonstrates diffuse marrow edema in the tibia,with a region of decreased T2 signal(arrow)likely corresponding to the sclerosis seen on radiography,Bone Lesions Organized by Cell of Origin(p367),1.Bone forming(Osteo-)lesion:Telangiectatic Osteosarcoma,Telangiectatic osteosarcoma:an osteolytic destructive sarcoma,which may mimic a benign aneurysmal bone cyst,毛细血管扩张型骨肉瘤是溶骨性破坏性肉瘤，影像表现类似于良性动脉瘤样骨囊肿,The presence of solid nodular components on MRI,helps to differentiate a telangiectatic osteosarcoma from a benign aneurysmal bone cyst,MRI,上固体结节成分的存在有助于区分毛细血管扩张型骨肉瘤和良性动脉瘤样骨囊肿,No bony matrix:unlike other osteosarcomas,不同于其他类型骨肉瘤，毛细血管扩张型骨肉瘤不产生骨基质,Bone Lesions Organized by Cell of Origin(p367),1.Bone forming(Osteo-)lesion:,Parosteal,Osteosarcoma,Parosteal(PAR-osteal)osteosarcoma:a juxtacortical osteosarcoma,arised from,the outer periosteum,皮质旁型骨肉瘤是近皮质骨肉瘤的一型，来源于骨膜外层,The most commonly location:at the posterior aspect of distal femoral metaphysis;has a cauliflower-like exophytic morphology,a lucent line separating it from the cortex,最常见发生在股骨远端干骺端的后部，呈菜花状外生性病灶，一条透亮线与骨皮质相分离,The age of Patients:usually 3040 years,older compared to other osteosarcoma subtypes,The least malignant of all osteosarcomas:with 90%5-year survival,Bone Lesions Organized by Cell of Origin(p367),1.Bone forming(Osteo-)lesion:,Parosteal,Osteosarcoma,Parosteal(PAR-osteal)osteosarcoma is a juxtacortical osteosarcoma that arises from,the outer periosteum.There is a cauliflower-like exophytic morphology and a lucent line separating it from the cortex,Bone Lesions Organized by Cell of Origin(p367),1.Bone forming(Osteo-)lesion:Periosteal,Osteosarcoma,Periosteal(PERI-osteal)osteosarcoma,the other juxtacortical osteosarcoma,arising from the inner periosteum,骨膜型骨肉瘤是另一型近皮质骨肉瘤，起源于骨膜内层，非常少见,Radiographic appearance:cortical thickening,aggressive periosteal reaction,and a soft-tissue mass,皮质增厚、骨膜反应受侵犯和软组织肿块,Histological feature:,chondroid differentiation,显示软骨分化,The most common location:the diaphysis of the femur or tibia,Patients tend to be younger than 20 years old,Bone Lesions Organized by Cell of Origin(p367),2.Cartilage-forming(Chondro-)lesion,Benign:,Synovial chondromatosis/osteochondromatosis,滑膜骨软骨瘤病,/,骨软骨瘤病,Enchondroma,内生软骨瘤,Osteochondroma,骨软骨瘤,Chondroblastoma,良性成软骨细胞瘤,Chondromyxoid fibroma,软骨粘液样纤维瘤,Malignant:,Chondrosarcoma,软骨肉瘤,Bone Lesions Organized by Cell of Origin(p367),Bone Lesions Organized by Cell of Origin(p367),Histological feature:,the formation of intra-articular lobulated cartilaginous nodules,which may or may not ossify;if ossify(osteochondromatosis),特征是形成关节内分叶状软骨结节，伴或不伴骨化，骨化称为骨软骨瘤病,The location:a monoarticular disorder,knee(most common),shoulders,hip,and elbow;Not to directly cause arthropathy,although the intraarticular nodules may cause mechanical erosions and secondary osteoarthritis,Radiography:multiple round intra-articular bodies of similar size and variable mineralization,The primary differential from osteoarthritis:intra-articular bodies tend to be more varied in size and shape and fewer in number in osteoarthritis,MRI:variable,depending on the degree of ossification and the presence of chondroid matrix,multiple globular and rounded foci of low signal if calcified or ossified,but the MRI finding is nonspecific and can also be seen in pigmented villonodular synovitis(PVNS),色素绒毛结节性滑膜炎,rounded calcified bodies in osteochondromatosis in a radiagraph,Malignant degenerate to chondrosarcoma:very rarely,2.Cartilage-forming(Chondro-)lesion:synovial chondromatosis/osteochondromatosis,Synovial osteochondromatosis:Frontal external rotation(left image)and internal rotation(right image)radiographs of the shoulder show multiple small round calcifications tracking along the expected location of the long head of the biceps tendon sheath(arrows),Bone Lesions Organized by Cell of Origin(p367),2.Cartilage-forming(Chondro-)lesion:synovial chondromatosis/osteochondromatosis,2.Cartilage-forming(Chondro-)lesion:synovial chondromatosis/osteochondromatosis,Synovial osteochondromatosis:Lateral radiographs of the knee show multiple small round calcifications,Bone Lesions Organized by Cell of Origin(p367),2.Cartilage-forming(Chondro-)lesion:Enchondroma,Benign,mature hyaline cartilage rests,良性发育成熟透明软骨病灶,Enchondroma features in the long bones:characteristic chondroid calcifications(,popcorn or ring and arc),特征为软骨钙化（爆米花或环或弧形）,The differential diagnosis of enchondroma:medullary bone infarct(which produces serpentine sclerosis)and chondrosarcoma,区分梗塞和内生软骨瘤，骨髓梗塞呈盘旋状硬化,T2-weighted images:enchondroma has a characteristic lobulated hyperintense signal,Enchondroma features in the hand:enchondroma typically does not produce visible matrix and appears as a geographic lytic lesion,Pathologic fracture;rarely undergo malignant transformation,Ollier and Maffucci syndrome:the key finding of malignant transformation being new pain in the absence of fracture;other findings including soft-tissue mass,destruction of the cortex,thickening of the cortex,Bone Lesions Organized by Cell of Origin(p367),2.Cartilage-forming(Chondro-)lesion:Enchondroma,Radiograph of the distal femur shows an enchondroma with Characteristic ring and arc chondroid-type calcification(arrow),Bone Lesions Organized by Cell of Origin(p367),2.Cartilage-forming(Chondro-)lesion:Enchondroma,Radiograph of the distal tibia shows an enchondroma with Characteristic ring and arc chondroid-type calcification,Bone Lesions Organized by Cell of Origin(p367),2.Cartilage-forming(Chondro-)lesion:Enchondroma,Enchondroma of the middle finger proximal phalanx(left image)complicated by pathologic fracture seen in a subsequent radiograph(right image).The enchondroma(arrow)has no perceptible chondroid matrix,which is a typical appearance of an enchondroma in the hand.Note the interval partial fusion of the physes occurring in the time interval between the two radiographs,Bone Lesions Organized by Cell of Origin(p367),2.Cartilage-forming(Chondro-)lesion:Enchondroma,Multiple enchondromas:the two familial enchondromatoses,Ollier syndromes(multiple enchondromas only),仅见于多发内生软骨瘤,Maffucci syndromes(multiple enchondromas and venous malformations producing phleboliths),多发内生软骨瘤和静脉畸形产生静脉石,Both syndromes carry an increased risk of malignant transformation to chondrosarcoma,with a higher risk in Maffucci syndrome,Bone Lesions Organized by Cell of Origin(p367),2.Cartilage-forming(Chondro-)lesion:Enchondroma,Frontal radiograph of the hand in a patient with Ollier syndrome shows numerous expansile,Bone Lesions Organized by Cell of Origin(p367),2.Cartilage-forming(Chondro-)lesion:Enchondroma,Frontal radiograph of the foot in a patient with Maffucci syndrome shows numerous expansile enchondromas most rominently in the great toe(red arrows).Multiple phleboliths(yellow arrows)represent soft-tissue venous malformations.Note the relative paucity of chondroid calcification,which is typical of the,enchondromas seen in Maffucci syndrome,Bone Lesions Organized by Cell of Origin(p367),2.Cartilage-forming(Chondro-)lesion:osteochondroma,The most common benign bone lesion,Histological feature:,cartilagecapped bony growth projecting outward from bone,often pedunculated,软骨帽样外突生长，常常带柄,Key features in radiolography:the continuity of cortex of host bone with the cortex of the osteochondroma and communication of the medullary cavities,骨皮质和肿瘤骨皮质相连续，髓腔相通。骨软骨瘤起源于干骺端，背离骨骺生长,Location:from the metaphysis and grows away from the epiphysis,Malignant transformation to chondrosarcoma,uncommon,an associated soft-tissue mass,a cartilage cap thickness 2 cm on MRI,伴发软组织肿块，,MRI,显示软骨帽厚度,2 cm,提示恶性转变为软骨肉瘤,Multiple osteochondromas:in familial osteochondromatosis(multiple hereditary exostoses),with increased risk for malign