组会文献汇报模板.ppt

,单击此处编辑母版标题样式,*,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,Preparation,Characterization,Cytotoxicity,and Genotoxicity Evaluations of Thiolated-and SNitrosated Superparamagnetic IronOxide Nanoparticles:Implications for Cancer Treatment,Amedea B.Seabra,*,Tatiane Pasquoto,Ana Carolina F.Ferrarini,Marconi da Cruz Santos,Paula S.Haddad,and Renata de Lima,Introduction,Result and discusion,Characterization of Thiolated Fe,3,O,4,Nanoparticles.,The results revealed that thiolated nanoparticles,have low toxicity,whereas S-nitroso nanoparticles were observed to cause cytotoxic and genotoxic eects in dierent cell lines.Furthermore,the magnetic property of the S-nitrosated nanoparticles was used as a tool to generate a local cytotoxic eect directly at the target site of application.S-Nitrosated nanoparticles appear to constitute a potentially promising agent for the treatment of cancer and prevention of the metastatic cascade;therefore,further studies are required to clearly understand the complex and wide-ranging roles of NO to facilitate its therapeutic usage.,Conclusion,