肿瘤转移-英文版.ppt

Designer:S.G.C.chen8332,海,.,水,.,正,.,蓝,.,作,.,品,NEXT,Designer:S.G.C.chen8332,海,.,水,.,正,.,蓝,.,作,.,品,NEXT,.,*,Cancer metastasis,1,.,What is metastasis?,Cancer Stem Cells,motivate and maintain the growth of cancer cells,potentiality,plasticity,make them easy to survive,Hypothesis of tumor metastasis,The phases of Cancer metastasis,The mechanism of cancer metastasis,Malignant Tumor metastasis pathway,Tumor metastasis,The molecules in the metastasis,The,phases,of Cancer metastasis,俞仁涛,Invasion(,侵犯,),Intravasation,（内渗）,Extravasation,（外渗）,Invasion,1.Stable cell movable cell,2.Protein expression,3.Movement mechanism,Relative genes,Intravasation,1.Angiogenesis,2.Immune escape,Extravasation,The inverse process of invasion,THE PROCESS OF TUMOR METASTASIS,Malignant Tumor metastasis pathway,恶性肿瘤常见的转移途径,Common metastasis pathway,1.,lymphatic metastasis,淋巴道转移,2.hematogenous,metastasis,血道转移,3.,implantation metastasis,种植性转移,Process,：,cancer cell,lymph vessel,regional lymph node,beyond,lymph node,hematogenous,metastasis,1.Lymphatic metastasize,2.Hematogenous,metastasis,lung,liver,Metastasis pathway,（,1,）,Body vein lung,（,2,）,Portal vein liver,（,3,）,pulmonary veins,Total body,（,brain,、,bone,、,kidney,、,adrenal glands,）,3.,Implantation metastasis,Chest,Celiac,Pericardial cavity,Bioremediation,生物治疗,Low side effects,Wide range,Clear goal,Mechanism of cell metastasis,Cell adhesion molecule(CAM),Degradation of extracellular matrix,Motility of tumor cells,Formation of vessels,Regulation of gene expression,Immunization,Cell adhesion molecule(CAM),Cadherin,Integrins,Selectin,IgSF,others,Degradation of extracellular matrix,丝氨酸蛋白酶类,半胱氨酸蛋白酶类（,Caspase,家族）,天冬氨酸蛋白酶类,基质金属蛋白酶类（,MMPs,）,Degradation of extracellular matrix,Proteoiytic enzymes(,蛋白水解酶,),溶解,ECM,ECM,是肿瘤侵袭和转移的天然屏障,Motility of tumor cells,Motility types,:,Random movement,Directional movement,Motility factors,:,Autoecrine,paracrine,Formation of vessels,Tumor metastasis relys on the forming of vessels.,Brief Introduction to,Molecules,in Cancer Metastasis,Three Sections,Tumour angiogenesis,Disaggregation,Intravasation,Tumour angiogenesis,Tumour angiogenesis has laid the foundation for tumour survival and tumour metastasis.,Tumour angiogenesis,Disaggregation,Broken down,Disaggregation,Upa,Cathepsins,MMPs,Disaggregation,Intravasation,