抗性糊精对饱食及体重控制的作用.ppt

Cliquez pour modifier le style du titre,Cliquez pour modifier les styles du texte du masque,Deuxime niveau,Troisime niveau,Quatrime niveau,Cinquime niveau,*,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,Effect of a resistant dextrin on satiety and weight management,抗性糊精对饱食与体重控制的作用,Laetitia,Deremaux,Study design,研究设计,Satiety,饱食,Hunger,feeling,饥饿感,Food,intake,食物摄入,STUDY,DESIGN,研究设计,Objectives,Study description,Population,Study product administration,Groups,Parameters,Schedule description,目的、研究描述、人群、研究产品服法、群组、参数、日程描述,RESULTS,结果,Satiety,Hunger feeling,Caloric&Food intake,Bodyweight,Body fat,饱食、饥饿感、热量及食物摄入、体重、体脂,CONCLUSION,结论,Bodyweight,体重,Bodyfat,体脂,Part I,:Study Design,第一部分,：研究设计,Study design,研究设计,Satiety,饱食,Hunger,feeling,饥,饿感,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,Study,design,Objectives:,Evaluation of the impact of,a,resistant dextrin,on,satiety,food intake,and,weight management,评价抗性糊精对饱食、食物摄入和体重控制的影响,Evaluation of the impact of,a,resistant dextrin,on,hunger feeling,and,body fat,评价,抗性糊精,对饥饿感及体脂的影响,Study design,研究设计,Satiety,饱食,Hunger,feeling,饥,饿感,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,Study description(,研究描述,),Randomized,placebo-,controlled,double-,blind,parallel,single,center,随机、安慰剂对照、双盲、平行、单中心,Implemented,in China,在中国实施,Study design,研究设计,Satiety,饱食,Hunger,feeling,饥,饿感,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,Study,design,Population(,人群,),20,healthy,overweight,Chinese,volunteers,per group(5 groups,20,volunteers),每组位健康超重中国自愿者（组自愿者）,Men,and,women,(,50/50),男性与女性（）,35,to 55,years,old,35,到,55,岁,Overweight(24,BMI 28 kg/m,2,);Chinese cut-off points for overweight,超重（,24,身体质量指数,28,公斤米,2,）；中国超重切分点,Factory workers,工厂工人,：,working 7 days a week at Li Pu manufacturing plant,荔浦制造厂每周工作天,eating at the canteen at every meals,每餐在食堂就餐,Study,design,Administration,(,服法,),Two,daily,intakes,of a,resistant,dextrin,in 250ml orange,juice,将抗性糊精融入,250,毫升橙汁，每天摄取两次,Placebo arm:Orange juice,安慰剂,组：橙汁,Treatment arms:Resistant dextrin at different dosages in orange juice,治疗组,：,在橙汁中加入不同剂量的抗性糊精,Study design,研究设计,Satiety,饱食,Hunger,feeling,饥,饿感,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,Study,design,Parallel study(,平行研究,),Group 1:Placebo,组,1,：安慰剂,Group 2:4g resistant dextrin,2 intakes=8g/day,组,2,：,4,克抗性糊精,2,次摄取,8,克天,Group 3:,7g resistant dextrin,2 intakes=14g/day,组,3,：,7,克抗性糊精,2,次摄取,14,克天,Group 4:9g resistant dextrin,2 intakes=18g/day,组,4,：,9,克,抗性糊精,2,次摄取,18,克天,Group 5:12g resistant dextrin,2 intakes=24g/day,组,5,：,12,克,抗性糊精,2,次摄取,24,克天,Study design,研究设计,Satiety,饱食,Hunger,feeling,饥,饿感,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,Study,design,Schedule description,Breakfast,7:00am,Lunch,12:00-12:30pm,Dinner,6:30pm,Placebo or,resistant,dextrin,Placebo or,resistant,dextrin,10:00am,4:00pm,Hunger,feeling questionnaire,(9:50am),Hunger,feeling questionnaire,(3:50pm),Satiety,evaluation,(VAS),from,10:00am to 12:00am,Satiety,evaluation,(VAS),from,4:00pm to 6:00pm,Food,intake,evaluation,(*),(*),(*),(*),Study design,研究设计,Satiety,饱食,Hunger,feeling,饥,饿感,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂Study,design,Part II:Results,第二部分,:,结果,Satiety,饱食,Hunger,feeling,饥饿感,Food,intake,食物摄入,Body,weight,体重,Body,fat,体脂,Study design,研究设计,Satiety,饱食,Hunger,feeling,饥饿感,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,Satiety,evaluation,by,VAS,饱食评价（按视觉模拟评分法）,The resistant dextrin has a positive and significant impact on satiety just after the first consumption at 14g,18g and 24g/day.,在首次摄取,14,克、,18,克和,24,克天后，抗性糊精对饱食有积极且明显的影响。,DAY 0,Orange,juice,consumption,Hunger,feeling,饥,饿感,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,Study design,研究设计,Satiety,饱食,Satiety,evaluation,by,VAS,饱食评价（按视觉模拟评分法）,DAY 21,From day 0 to day 21,the resistant dextrin has shown a progressive and strong impact on satiety.At day 21 and before day 21,the resistant dextrin has shown a significant modulation of satiety at 8g,14g,18g and 24g/day.,从首日到第,21,日，抗性糊精已显示出对饱食有渐进及较强的影响。在第,21,日及之前，每日摄取,8,克、,14,克。,18,克及,24,克,/,天，抗性糊精已显示出对饱食有明显的调节作用。,Orange,juice,consumption,Hunger,feeling,饥,饿感,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,Study design,研究设计,Satiety,饱食,Satiety,evaluation,by,VAS,饱食评价（按视觉模拟评分法）,The effect of the resistant dextrin on satiety is time correlated and the effects are clear from day 0.,抗性糊精对饱食的作用与时间相关，且从首日开始有作用。,Orange,juiceconsumption,Hunger,feeling,饥,饿感,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,Study design,研究设计,Satiety,饱食,The consumption of the resistant dextrin has a positive impact on the hunger feeling score over the study period with a statistical difference from day 5.,在研究期间，使用抗性糊精饥饿感评分有正面影响，从第天起有差异。,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,Study design,研究设计,Satiety,饱食,Hunger,feeling,饥饿感,Hunger,feeling,饥饿感,Hunger,feeling,饥饿感,The number of volunteers,who are not hungry,has increased over the study period with a dose-effect relation.,不饿的自愿者人数在研究期间增加，具有量效关系。,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,Study design,研究设计,Satiety,饱食,Hunger,feeling,饥饿感,Food,intake,食物摄入,The resistant dextrin has shown a significant decrease in food intake at lunch over the study period,from week 3.,从第周期，抗性糊精在研究期间明显减少午餐食物摄入量,Bodyweight,体重,Bodyfat,体脂,Study design,研究设计,Satiety,饱食,Food,intake,食物摄入,Hunger,feeling,饥,饿感,Body,weight,体重,The resistant dextrin has shown a significant decrease in bodyweight from-0.42kg at 14g/day.This weight lost became higher with the increase of the dosage of the resistant dextrin.,用量为克天时，抗性糊精明显减少体重,0.42,公斤起。随着抗性糊精用量增加，减重更大。,Bodyfat,体脂,Study design,研究设计,Satiety,饱食,Hunger,feeling,饥,饿感,Food,intake,食物摄入,Bodyweight,体重,Body,fat,体脂,The resistant dextrin has shown a significant decrease in body fat from-0.12%at 18g/day.This body fat decrease became higher with the increase of the dosage of the resistant dextrin.,用量为克天时，抗性糊精明显减少体重,.,起。随着抗性糊精用量增加，体脂继续减少。,Study design,研究设计,Satiety,饱食,Hunger,feeling饥,饿感,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,Part III,:Conclusion,第三部分,：结论,Study design,研究设计,Satiety,饱食,Hunger,feeling,饥饿感,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,Conclusion,S,There is a logical,correlation,between the biomarkers leading to an overall improvement,The,daily inclusion of the resistant dextrin,induces a,progressive,impact on,satiety,inducing positive effects on the decrease of the,food intake,with a direct impact on the management of,bodyweight,and,body fat.,This study shows a clear,dose-effect,relation,造成整体改进的生物标志物之间存在逻辑,相关性,日常摄取抗性糊精,对,饱食产生渐进影响,，对,食物摄入,的减少产生积极的作用，对控制,体重和体脂,有直接影响。,本研究显示出清晰的,量效,关系,Study design,研究设计,Satiety,饱食,Hunger,feeling,饥饿感,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,The RESISTANT DEXTRIN has demonstrated strong effects,in satiety and weight management,抗性糊精饱食和体重控制具有强效,Conclusion,S,Study design,研究设计,Satiety,饱食,Hunger,feeling,饥饿感,Food,intake,食物摄入,Bodyweight,体重,Bodyfat,体脂,