2024+WFNS建议：保守治疗在腰椎间盘突出症中的作用.pdf

World Neurosurgery:X 22(2024)100277Available online 13 February 20242590-1397/2024 The Authors.Published by Elsevier Inc.This is an open access article under the CC BY-NC-ND license(http:/creativecommons.org/licenses/by-nc-nd/4.0/).The role of conservative treatment in lumbar disc herniations:WFNS spine committee recommendations Onur Yamana,Artem Guchkhab,Sandeep Vaishyac,Mehmet Zilelid,*,Corinna Zygourakise,Joachim Oertelf aDepartment of Neurosurgery,Memorial Bahelievler Hospital,Istanbul,Turkiye bDepartment of Neurosurgery,Research Center of Neurology,Moscow,Russia cDepartment of Neurosurgery,Fortis Memorial Research Institute,Guragaon and Fortis Hospital Vasant Kunj,New Delhi,India dDepartment of Neurosurgery,Sanko University Faculty of Medicine,Gaziantep,Turkiye eDepartment of Neurosurgery,Stanford University School of Medicine,Stanford,CA,USA fDepartment of Neurosurgery,Saarland University Medical Centre,Homburg,Germany A R T I C L E I N F O Keywords:Lumbar disc herniation Conservative therapy Low back pain Radiculopathy WFNS spine committee A B S T R A C T Objective:To formulate the most current,evidence-based recommendations for the conservative management of lumbar disc herniations(LDH).Methods:A systematic literatre search was performed 20122022 in PubMed/Medline and Cochrane using the keywords lumbar disc herniation and conservative treatment,yielding 342 total manuscripts.Screening criteria resulted in 12 final manuscripts which were summarized and presented at two international consensus meetings of the World Federation of Neurosurgical Societies(WFNS)Spine Committee.The Delphi method was utilized to arrive at three final consensus statements.Results and conclusion:s:In the absence of cauda equina syndrome,motor,or other serious neurologic deficits,conservative treatment should be the first line of treatment for LDH.NSAIDs may significantly improve acute low back and sciatic pain caused by LDH.A combination of activity modification,pharmacotherapy,and physical therapy provides good outcomes in most LDH patients.1.Introduction Lumbar disc herniation(LDH)is the most common degenerative disease of the spine,with a prevalence of 23%.1 Nevertheless,only a small percentage of patients(10%)are candidates for surgical inter-vention.2 Red flags that necessitate urgent surgery include progressive significant weakness of the lower extremities and/or cauda equina syndrome.In the absence of red flag symptoms,conservative ther-apyincluding non-steroid anti-inflammatory drugs or narcotic medi-cations,physical therapy,and/or epidural transforaminal injectionsshould be the first line of treatment.3 In this paper,we re-view the recent literature and summarize the results of the World Federation of Neurosurgical Societies(WFNS)Spine Committee consensus meeting for the role of conservative therapy in LDH.2.Methods We performed a literature search in Pubmed,Medline and Cochrane 20122022 using the keywords lumbar disc herniation and con-servative treatment.Initial search yielded 342 manuscripts.We excluded duplicate articles,those without full text available,non-English articles,non-human studies,and case reports with 50 pa-tients.These screening criteria(as shown in Fig.1)resulted in 12 final articles that covered the following topics1:Type of conservative therapy used for LDH,and2 Effectiveness of conservative therapy in treating LDH(see Table 1).These data were summarised and presented at two international meetings of the World Federation of Neurosurgical Societies(WFNS)Spine Committee,the first in Karachi,Pakistan and the second in Istanbul,Turkey.Participants voted on consensus statements using the following Likert scale:1=strongly disagree,2=disagree,3=some-what agree,4=agree,5=strongly agree.All voters were attending neurosurgeons who are spine experts and members of the WFNS*Corresponding author.E-mail addresses:(O.Yaman),(M.Zileli).Contents lists available at ScienceDirect World Neurosurgery:X journal homepage: https:/doi.org/10.1016/j.wnsx.2024.100277 Received 28 July 2023;Received in revised form 18 November 2023;Accepted 1 February 2024 World Neurosurgery:X 22(2024)1002772committee.Results are presented as percentage of respondents who agree35 and those who diagree.1,2 Consensus was achieved when agreement or disagreement were66%,respectively.3.Results and discussion 3.1.Definition of“conservative therapy”The term conservative therapy refers to all treatment modalities for LDH except surgery.This includes pharmacological and non-pharmacological treatments including physical therapy,injections,and other minimally-invasive procedures,as discussed below.3.2.Pharmacological therapy 3.2.1.Acetaminophen Both the American Pain Society(APS)and the American College of Physicians(ACP)recommend acetaminophen as the first-line of treat-ment against low back pain of any duration.Although it might be not be as effective as other agents for severe pain,it is still the first choice due to its low adverse effects.4 3.2.2.Nonsteroidal anti-inflammatory drugs(NSAIDs)NSAIDs inhibit cyclooxygenase-1(COX-1)and cyclooxygenase-2(COX-2)enzymes,resulting in anti-inflammatory and analgesic effects,and are frequently used for discogenic pain.In Roelofs et al.s Cochrane review,the authors stated that non-selective NSAIDs are superior to placebo for relieving low back pain without the need for additional analgesics.5 There is no published evidence that one individual NSAID is superior to another for treating LDH pain.3.2.3.Muscle relaxants The term muscle relaxant is used for the group of medications that relax skeletal muscles via various mechanisms.One commonly used group is thiocolchicoside,a GABA-mimetic drug,which also has anti-inflammatory and analgesic effects.Other agents like carisoprodol(soma),cyclobenzaprine(flexeril),and metalaxone(skelaxin)can also be used for the treatment of acute low back pain,despite known side effects such as gastrointestinal problems,dizziness,and headaches.6 Muscle relaxants like the calcium-channel blocker dantrolene or the gamma-aminobutyric acid modulator baclofen should generally not be used for treatment of low back pain,as their therapeutic purposes are Abbreviations WFNS World Federation of Neurosurgical Societies MRI Magnetic resonance imaging CT Computed tomography PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses LDH Lumbar disc herniation APS American Pain Society ACP American College of Physicians NSAIDs Nonsteroidal anti-inflammatory drugs COX-2 Cyclooxygenase-2 Fig.1.Flowchart depicting screening algorithm for papers.O.Yaman et al.World Neurosurgery:X 22(2024)1002773aimed for treatment for muscle stiffness related to spinal cord injuries,cerebral palsy,or stroke.4 3.2.4.Opiods The use of opiods for the treatment of low back pain is controversial due to serious side effects including physical dependency and with-drawal symptoms such as as gastrointestinal discomfort,irritability,and headaches.In fact,Alford reported that chronic back pain is commonly used as an excuse for long-term opioid prescriptions and does not positively affect quality of life or reduce symptoms.7 High-quality data for the long-term use of opiods specifically for LDH-related pain is lacking.Nevertheless,Tramadol,a-opiate agonist acting as a norepi-nephrine and serotonin reuptake inhibitor,is shown to have remarkably beneficial effects on radicular pain caused by LDH,with fewer adverse effects than other opioids.8 3.3.Non-pharmacological treatment 3.3.1.Physical therapy Physical therapy plays an important role in the management of dis-cogenic pain.Back extension exercises,like the McKenzie extension-program and behavioral posture changes,have been shown to improve LBP by causing anterior migration of disc tissue.Similar results may be achieved by yoga or tai-chi extension-based excersises.Flexion movements,however,may lead to posterior disc mifration and further aggravate LDH-related pain.9 The effect of physical therapy on radicular pain remains controversial.3.3.2.Traction therapy As a part of a physical therapy program,traction therapyeither manually or with traction devicesaims to reduce the mechanical load of the disc and expand the neural foramina.Most case series and meta-analyses,however,indicate that traction only temporarily improves LBP or radicular pain and poses serious risks including traction-induced nerve injury,ligament tears,or vertebral fractures.Traction does not appear to have a beneficial effect on spinal mobility.10 3.3.3.Bed rest Limiting all physcial activity for more than two days is defined as“bed rest”.In a retrospective cohort of 23 patients with LDH,Altun et al reported that 2 weeks of bed rest reduced low back pain due to LDH.11 In their meta-analysis of 49 studies,however,Jordon et al found that bed rest may be no more effective than watching waiting at improving pain scores at 12 weeks in patients with sciatica.12 3.3.4.Traditional medicine Traditional medicine like accupuncture and cupping therapy have been practiced for over 2000 years in China,India,and the Middle East and are becoming more popular in the western world.Although there are a handful of low-quality studies supporting the benefits of traditional medicine,a large meta-analyis published in 2005 stated that accu-puncture may provide immediate or short-term relief of chronic LBP,but there is insufficient high-quality evidence showing a positive effect on discogenic pain.13 Table 1 Summary of the reviewed papers.No Study Evidence Level Number of patients Main target Conclusions 1 Zhang B.et al,2017 1 Metaanalysis of 80 papers Evaluation of the effect of non-surgical therapy(Chinese traditional medicine,pharmacotherapy and physical therapy)on lumbar disc hernia Non-surgical therapy has favorable outcomes in patients with lumbar disc hernia;traditional Chinese medicine(manual therapy,accupuncture etc)is favorable of having less side effects than pharmacotherapy 2 Boyraz I.et al,2015 3 65 Comparison of high-intensity laser therapy and ultrasound treatment in patients with lumbar discopathy HILT and US treatment are effective in lumbar discopathy and had longer positive outcomes compared to pharmacotherapy only 3 Paul CP.et al,2017 2 125 Evalutation of static axial loading on intervertebral disc space in a goat biomechanical model Concurrent static axial loading results in the posterolateral part of the intervertebral disc 4 Altun I.et al,2017 3 23 Investigation of effect of bed rest on lumbar disc hernia Bed rest positively reacts on lumbar disc hernia-induced pain in combination with pain therapy 5 Kreiner DS.et al,2014 1 Review based on 29 clinical questions What is the likihood that a patient with lumbar disc herniation and radiculopath undergoing medical treatment would have good/excellent functional outcomes at short,medium and long term?Medical treatment is suggested to improve functional outcomes in most patients with lumbar disc herniation and radiculopathy 6 Kaye AD.et al,2021 1 Review of 21 trials Comparision of the different administration routes of epidural injections Epidural injections with local anesthetic and steroid showed level I evidence for transforaminal and interlaminar approaches;local anesthesia alone was noted as level II evidence;Caudal injections with local anestehsia or steroids showed level II efficacy 7 Jordan JL.et al,2011 1 37 reviews Investigate the effect of epidural steroid injections on lumbar disc hernia Epidural steroid injections are shown to improve limb pain and increasing patients satisfactions at 2 weeks but show no effect after 2 weeks 8 Chiu CC.et al,2015 1 31 articles Evaluation of possibility of spontaneous regression of lumbar disc hernia Spontaneous regression of herniated lumbar disc may result in 6090%of patients 9 Hu D.et al,2020 3 31 Comparision of 12 and 24-month follow-up of patients receving conservative treatment and minimally-invasive percutaneous discectomy for lumbar disc herniation Patients who underwent percutaneous discectomy had significantly better VAS scores than the ones who received conservative therapy 10 Demirel A.et al,2017 3 29 Does non-invasive spinal decompression physical therapy effect the reabsorption of lumbar disc hernia?Extension exercises reduce stress on the lumbar disc,wheras constant flexion movements may increase it 11 Gastaldi R.et al,2019 2 54 Comparing the efficacy and safety of intravenous ketoprofen and methyprednisolone with placebo in sicatica NSAIDs are effective for short-time symptomatic treatment of LBP;A higher propotion of patients relieved with intravenous methyprednisolone at day 3 12 Noble M.et al,2018 1 4893 Evaluation the effectiveness of opiods on non-cancer pain Despite significant relieve of pain,up to 23%patients showed serious adverse effects and discontinued opioid treatment.Improvement of quality of life were inconclusive O.Yaman et al.World Neurosurgery:X 22(2024)10027743.3.5.Injections Administration of local anesthesia,corticosteroids,or a mixture of both through the sacral hiatus,interlaminar space,neural foramen,or facet capsule has been widely performed for the non-surgical treatment of LDH.These injected agents are believed to reduce the inflammatory response of the herniated disc and reduce edema,thereby decreasing neural compression.Althogh injection therapies,are beneficial in selected LDH patients,long-term outcomes are worse than surgical outcomes,particularly when focusing on radicular pain.They can be useful in patients with significant comorbidities who are not suitable surgical candidates or in patients who wish to avoid surgical interven-tion.However,reports indicate that a high portion of patients under-going injection therapy may still end up requiring surgery in the long-term.14 3.3.6.Intradiscal interventions The majority of herniatied discs are filled with water.As a result,intradiscal interventions like nucleoplasty with lasers or radiofrequency via a temperature-controlled resistive heating coil are believed to work by evaporating the water content of the disc tissue,thereby reducing the herniated mass with thermal energy and also denervating the annulus.Reports show short-term improvement in LBP and radiculopathy,but there is insufficient evidence that intradiscal therapies provide long-term benefit in the treatment of LDH-associated pain,and many pa-tients may still require surgery in the future.15 3.3.7.WFNS spine committee recommendations Following two rounds of voting in the international consensus meetings,the WFNS Spine Committee produced the following recom-mendatons on the conservative treatment of lumbar disc herniations:1)NSAIDs have significant positive effect on improving acute low back and sciatic pain caused by LDH 2)Conservative treatment is recommended as the first-line treatment for LDH in patients who do not have neurologic deficits such as motor deficits or cauda equina syndrome.4.Conclusion LDH-related low back pain and radiculopathy represents one of t