AMI LineTOC仪器手册 Version 6.20.pdf

AMI LineTOCVersion 6.20 and higherA-96.250.621/020317Operators Manual 2017,SWAN ANALYTISCHE INSTRUMENTE AG,Switzerland,all rights reservedsubject to change without noticeCustomer SupportSWAN and its representatives maintain a fully trained staff of technical specialists around the world.For any technical question,contact your nearest SWAN representative,or the manufacturer:SWAN ANALYTISCHE INSTRUMENTE AGStudbachstrasse 138340 HinwilSwitzerlandInternet:www.swan.chE-mail:supportswan.chDocument StatusTitle:Monitor AMI LineTOC Operators ManualID:A-96.250.621RevisionIssue00August 2010First release01July 2011Redesign of Instrument02Dec.2011Drop counter removed03May 2014Update to FW version 5.42,new Mainboard V 2.404March 2017Update to FW version 6.20,new Mainboard V 2.5AMI LineTOCA-96.250.621/0203171Table of Content1.Safety Instructions.31.1.Warning Notices.41.2.General Safety Regulations.51.3Restrictions for use.62.Product Description.72.1.Description of the System.92.2.Verification.122.3.Calibration .122.4.Function Test.132.5.System Suitability Test for Pharma .142.6.Fluidics Overview.152.7.Instrument Specification.192.8.Instrument Overview.213.Installation.223.1.Installation Checklist.223.2.Mounting of Instrument Panel.233.3.Connect Sample and Waste.233.4.Electrical Connections.243.4.1Electrical Connection Scheme.263.4.2Power Supply.273.5.Relay Contacts.283.5.1Input.283.5.2Alarm Relay.283.5.3Relay 1 and 2.293.6.Signal Outputs.313.6.1Signal Output 1 and 2(current outputs).313.7.Interface Options .313.7.1Signal Output 3.323.7.2Profibus,Modbus Interface.323.7.3HART Interface.333.7.4USB Interface.334.Instrument Setup.344.1.Standard-and stock solutions .344.2.Peristaltic Pump.344.3.Establish Sample Flow.354.4.Programming.364.5.Commissioning.362A-96.250.621/020317AMI LineTOC5.Operation.375.1.Keys,Display.375.2.Software Structure.405.3.Changing Parameters and values.415.4.Grab Sample.426.Maintenance.446.1.Maintenance Schedule.456.2.Stop of Operation for Maintenance.466.3.Verification.466.4.Calibration.496.5.Function Test Pharma.516.6.Function Test UPW.546.7.System Suitability Test(SST).566.8.Replace the peristaltic pump tubes.606.9.Tube Numbering.626.10.Replace the UV-Reactor.656.11.Replace Air Filters.686.12.Replace Fuses.696.13.Longer Stop of Operation.707.Error List.718.Program Overview.758.1.Messages(Main Menu 1).758.2.Diagnostics(Main Menu 2).768.3.Maintenance(Main Menu 3).778.4.Operation(Main Menu 4).778.5.Installation(Main Menu 5).789.Program List and Explanations.801 Messages.802 Diagnostics .803 Maintenance .834 Operation.855 Installation.8610.Default Values.9811.Index.10112.Notes.103AMI LineTOCSafety InstructionsA-96.250.621/0203173AMI LineTOC-Operators ManualThis document describes the main steps for instrument setup,oper-ation and maintenance.1.Safety InstructionsGeneralThe instructions included in this section explain the potential risks associated with instrument operation and provide important safety practices designed to minimize these risks.If you carefully follow the information contained in this section,you can protect yourself from hazards and create a safer work environ-ment.More safety instructions are given throughout this manual,at the respective locations where observation is most important.Strictly follow all safety instructions in this publication.TargetaudienceOperator:Qualified person who uses the equipment for its intended purpose.Instrument operation requires thorough knowledge of applications,instrument functions and software program as well as all applicable safety rules and regulations.OM LocationThe AMI Operators Manual shall be kept in proximity of the instru-ment.Qualification,TrainingTo be qualified for instrument installation and operation,you must:read and understand the instructions in this manual as well as the Material Safety Data Sheets.know the relevant safety rules and regulations.4A-96.250.621/020317AMI LineTOCSafety Instructions1.1.Warning NoticesThe symbols used for safety-related notices have the following sig-nificance:DANGERYour life or physical wellbeing are in serious danger if such warnings are ignored.Follow the prevention instructions carefully.WARNINGSevere injuries or damage to the equipment can occur if such warnings are ignored.Follow the prevention instructions carefully.CAUTIONDamage to the equipment,minor injury,malfunctions or incor-rect process can be the consequence if such warnings are ig-nored.Follow the prevention instructions carefully.MandatorySignsThe importance of the mandatory signs in this manual.Warning SignsThe importance of the warning signs in this manual.Safety gogglesSafety glovesAMI LineTOCSafety InstructionsA-96.250.621/02031751.2.General Safety RegulationsLegalRequirementsThe user is responsible for proper system operation.All precautions must be followed to ensure safe operation of the instrument.Spare PartsandDisposablesUse only official SWAN spare parts and disposables.If other parts are used during the normal warranty period,the manufacturers warranty is voided.ModificationsModifications and instrument upgrades shall only be carried out by an authorized Service Technician.SWAN will not accept responsi-bility for any claim resulting from unauthorized modification or alter-ation.Electrical shock hazardCorrosiveHarmful to healthFlammableWarning generalAttention general6A-96.250.621/020317AMI LineTOCSafety InstructionsWARNINGRisk of Electrical ShockIf proper operation is no longer possible,the instrument must be disconnected from all power lines,and measures must be taken to prevent inadvertent operation.To prevent from electrical shock,always make sure that the ground wire is connected.Service shall be performed by authorized personnel only.Whenever electronic service is required,disconnect instru-ment power and power of devices connected to.relay 1,relay 2,alarm relayWARNINGFor safe instrument installation and operation you must read and understand the instructions in this manual.WARNINGOnly SWAN trained and authorized personnel shall perform the tasks described in this document.1.3.Restrictions for useCAUTIONThe sample must not contain any particles,which may block the UV-reactor.Sufficient sample flow is coercive for the correct func-tion of the instrument.AMI LineTOCProduct DescriptionA-96.250.621/02031772.Product DescriptionApplicationThe determination of organic components contained in water al-lows an extensive statement about its purity.The instrument AMI LineTOC is the result of comprehensive experi-ences in development of analytical instruments.The combination of a high efficient oxidation technique with modern detection-and evaluation-methods guarantees an accurate monitoring of pure and ultra-pure water.The application range covers the demand of both,the pharmaceuti-cal industry and ultra pure water(UPW)applications.Due to the re-strictive international regulations for the pharmaceutical industry,some options in the menu of the transmitter are not visible,but re-placed by fix values.SignalOutputsTwo signal outputs programmable for measured values(freely scal-able,linear,bilinear,log)or as continuous control output(control parameters programmable).Current loop:0/420 mAMaximal burden:510 OhmThird signal output available as an option.The third signal output can be operated as a current source or as a current sink(selectable via switch).RelaysTwo potential-free contacts programmable as limit switches for measuring values,controllers or timer for system cleaning with au-tomatic hold function.The relay contacts can be set as normally open or normally closed with a jumper.Maximum load:1 A/250 VACAlarm RelayOne potential free contact.Alternatively:Open during normal operation,closed on error and loss of power.Closed during normal operation,open on error and loss of power.Summary alarm indication for programmable alarm values and in-strument faults.InputFor potential-free contact to freeze the signal outputs or to interrupt control in automated installations(hold function or remote-off).8A-96.250.621/020317AMI LineTOCProduct DescriptionCommunica-tion Interface(optional)USB Interface for logger download Third signal output(can be used in parallel to the USB interface)RS485 with Fieldbus protocol Modbus or Profibus DP HART interfaceSafetyFeaturesNo data loss after power failure.All data is saved in non-volatile memory.Over voltage protection of in-and outputs.Galvanic separation of measuring inputs and signal outputs.Grab SampleThe grab sample mode can be used for measurement of external samples which are not connected to the sample inlet.MeasuringModesThe menu structure of the AMI LineTOC transmitter is divided in the two different main parts“Pharma”and“UPWcalled measuring modes.OperatingModesThe AMI LineTOC provides the following operating modes:On-line mode Grab sampleIn on-line mode the sample is sucked through the system from the sample inlet and measured(see On-line mode,p.17).In grab sample mode the sample is sucked through the system from a bottle and measured.The bottle is fixed on position 2(see Instrument Specification,p.19).ConductivityModelDescription of conductivity model CO2 see Conductivity Model CO2,p.10.Description of conductivity model coefficient see Conductivity Mod-el Coefficient,p.11.TestsDependent on the measuring mode and conductivity model of the AMI LineTOC the following tests are active:Conductivity modelMeasuring modeCO2CoefficientPharma Verification Function Test SST Calibration Function Test SSTUPW Verification Function Test Calibration Function TestAMI LineTOCProduct DescriptionA-96.250.621/0203179Definitions2.1.Description of the SystemMeasuringprincipleThe basic principle of most TOC measurement methods is the oxi-dation of the organic carbon to CO2 followed by detection.RequirementsofInternationalPharma-copoeiaInternational Standards related to the determination of the sum pa-rameter TOC are:ISO 8245TOC in water USP(643)TOC in pharmaceutical water(AP,WFI)Ph.Eur.2.2.44TOC in pharmaceutical water(AP,WFI)TCTotal CarbonThe sum of inorganic and organic bound carbonTICTotal Inorganic CarbonThe sum of inorganic carbon in dissolved and non dis-solved compoundsTOCTotal Organic CarbonThe amount of carbon in organic compoundsAPAqua PurificataWFIWater for InjectionPWPure WaterUSPUnited States PharmacopeiaEPEuropean PharmacopeiaSampleSignalSample(Online or Grab sample)Sample oxidation withUV-LightCalculation of TOCContent in ppbConductivity 1Conductivity 210A-96.250.621/020317AMI LineTOCProduct DescriptionIt is assumed that the TOC is proportional to the concentration of microorganisms or other organic contaminants in water,which may be introduced into the water through the source,purification sys-tems,tubes or from biofilm growing in the system.Is the TOC-content less than a defined amount,it is assumed that the contamination is not significant from the pharmaceutical point of view.The TOC limit value for WFI and PW defined by the USP and EP is 500 ppb.The applied method for determination of the TOC is irrele-vant.Both standardizations have established special guidelines for the qualification of the applied method through the system suitability test(SST).System suitability refers to the ability of the instrument to efficiently oxidize a substance that is not easily oxidized.The AMI LineTOC is able to perform the system suitability test au-tomatically,the operator only needs to activate the program func-tion and provide both standard solutions at the corresponding ports.Analysis and calculation is then performed automatically by the in-strument and displayed on the display after termination of the mea-surements.ConductivityModel CO2The pharmaceutical industry and the semiconductor industry re-quire large amounts of deionized water with a TOC content in a low ppb range.This water contains no salt,but only organic com-pounds and dissolved carbon dioxide from the atmosphere.If the organic carbon compounds:are dissolved are non-ionic(no organic acids,etc.),consist only of the elements C,H and O(carbon,hydrogen and oxygen),it is possible to determine the TIC and TC by complete UV-oxida-tion and direct conductivity measurement.If temperature and pressure are known,the conductivity of these samples is determined only by the total carbon dioxide content.Carbon dioxide reacts with water to carbonic acid,which dissoci-ates partially to hydrocarbonate ions and carbonate ions.The total carbon dioxide content is the sum of all these species.The compo-sition of the sample in the chemical equilibrium is exactly deter-mined according to the law of mass action.Through the definite relation of conductivity and total carbon diox-ide content,the TIC and TOC can be calculated from the measured conductivity of the sample.AMI LineTOCProduct DescriptionA-96.250.621/02031711Prior to oxidation the conductivity corresponds to the TIC,after oxi-dation,the conductivity corresponds to the TC.The TOC is calcu-lated from the difference of TC-TIC.The determination of TIC and TOC under the above described con-ditions is an absolute method,i.e.for a particular TIC or TOC con-centration,the conductivity is given exactly.An alignment of the conductivity with TOC calibration solutions is therefore not neces-sary.If the instrument does not measure the defined TOC concentration of a standard solution within the limits of measurement accuracy,it is caused by one or more of the following reasons:the above described conditions are not fulfilled,the deviation of the measurement is caused by a defect of the instrument,the deviation of the measurement is caused by incorrect op-erating parameters of the transmitter.Should wrong measurements occur,request for a qualified service technician.ConductivityModelCoefficientThe conductivity model coefficient is based on a 2-point calibration.A straight line is drawn through two points of a TOC-conductivity di-agram.One point is measured with dilution water,the other point is measured with calibration standard.It is assumed that the TOC content is approximately proportional to the increase of conductivity caused by oxidation.During the on-line measurement and the calibration the sample is kept at a constant temperature of 4243 C.Therefore normally it is not necessary to consider the temperature dependence for cal-culating the TOC content of the sample.Under certain conditions however it may be necessary to alter the percent value of the Coefficient,see 5.1.1.1.2.1,p.86.12A-96.250.621/020317AMI LineTOCProduct Description2.2.Verification NOTICE:A verification can be carried out only if the conductivity model“CO2“is selected.The AMI LineTOC is calibrated in the factory.Since the accuracy of TOC measurements depends directly on the calibration of the in-strument,it is recommended to verify the calibration at regular in-tervals(see Maintenance Schedule,p.45).The calibration parameters are verified by measuring a standard solution with a known TOC concentration.The need of the instrument verification is also issue of inter