1、Immunoglobulin IsotypesDefinition-Antigenic determinants that characterize the classes and subclasses of heavy chains and types and subtypes of light chainsHuman IgMantiserumReacts withIgM,IgG,IgA,IgD,IgEReact with IgG,IgA,IgD and IgEAbsorbed antiserumReacts only with IgMRecognizes determinantsspeci
2、fic for heavy chains(isotypes)Immunoglobulin Isotypes?Immunoglobulin IsotypesOccurrenceImportanceIg levelsB cell tumorsImmunodeficiencies Definition LocationIgM(kappa)IgG1(kappa)Immunoglobulin Allotypes Definition-Antigenic determinants specified by allelic forms of the Ig genes Location Occurrence
3、Source of anti-allotypic AbsIgG1(kappa)Person 2IgG1(kappa)Person 1Human Immunoglobulin Allotypes Nomenclature G1m(3)Km(1)Human Immunoglobulin Allotypes Genetics(alleles)Co-dominant autosomal genesKm(1)/Km(3)X Km(1)/Km(1)Km(1)/Km(1)and Km(1)/Km(3)Allelic exclusionGenetics(pseudoalleles)Co-dominantG1m
4、17)G1m(1)214355-358Human Immunoglobulin AllotypesImmunoglobulin AllotypesDefinitionLocationOccurrenceImportanceMonitoring bone marrow graftsForensic medicinePaternity testingImmunoglobulin IdiotypesDefinition-Unique antigenic determinants present on individual antibody molecules or on molecules of
5、identical specificityDNP-BSAStrain A MouseAnti-DNP Ab Purifiedanti-DNP AbStrain A Mouse Ab againstcombining site of anti-DNP Ab?Immunoglobulin IdiotypesAntigenic determinants created by the HVR=IdiotypesImmunoglobulin IdiotypesDefinitionLocationIgG1(kappa)Person 1anti-BIgG1(kappa)Person 1anti-AImmun
6、oglobulin IdiotypesDefinitionLocation ImportanceV region markerRegulation of immune responsesAgIdanti-Id+-anti-anti-Id+-Regulation by Id/anti-IdImmunoglobulin IdiotypesDefinitionLocation ImportanceV region markerRegulation of immune responsesVaccinesAgIdanti-Id+-Anti-Idiotype VaccinesAgIdanti-Id+Immunoglobulin IdiotypesDefinitionLocation ImportanceV region markerRegulation of immune responsesVaccinesTreatment of B cell tumors(T cell)
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