SCI审稿意见回复范文.doc

论文题目：Pharmacokinetic and pharmacodynamic studies on the antivirus effects of A (一种中草药) against virus B （一种病毒）
所投杂志：Life Sciences
投稿结果：这次大修后又经过一次小修，被接受发表
编辑信内容（注：有删节）：
Dear Mr. XXX,
Your manuscript has been examined by the editors and qualified referee . We think the manuscript has merit but requires revision before we can accept it for publication in the Journal. Careful consideration must be given to the points raised in the reviewer comments, which are enclosed below.
If you choose to submit a revision of your manuscript, please incorporate responses to the reviewer comments into the revised paper. A complete rebuttal with no manuscript alterations is usually considered inadequate and may result in lengthy re-review procedures.
A letter detailing your revisions point-by-point must accompany the resubmission.
You will be requested to upload this Response to Reviewers as a separate file in the Attach Files area.
We ask that you resubmit your manuscript within 45 days. After this time, your file will be placed on inactive status and a further submission will be considered a new manuscript.
To submit a revision, go to and log in as an Author.
You will see a menu item called Submission Needing Revision. You will find your submission record there.
Yours sincerely,
Joseph J. Bahl, PhD
Editor
Life Sciences
Format Suggestion: Please access the Guide to Authors at our website to check the format of your article. Pay particular attention to our References style.

Reviewers' comments:
Reviewer #1:
XXXXX （略）
Reviewer #2:
XXXXX （略）
Editors note and suggestions: （注：编辑的建议）
Title: Re-write the title to read more smoothly in contemporary English>>>
Pharmacokinetic and pharmacodynamic studies of the antiviral effects of A against virus B.
Abstract: Re-write the abstract to read more smoothly.
A, an alkaloid isolated from C (注：一种中草药), was tested for antiviral activity against virus B. Both in vitro and in vivo assays along with serum pharmacological experiments showed A to have potent antiviral activity. The pharmacokinetic profile of A in Sprague/Dawley rat plasma after oral administration was measured by HPLC. Blood samples taken at selected time points were analyzed to study potential changes in antiviral pharmacodynamics as measured by infectivity of viruses. From the similarity of the serum concentration profiles and antiviral activity profiles it is concluded that A it self, rather than a metabolite, exerted the effect against the virus prior to bioinactivation. The need for effective clinical agents against virus B and these results suggest the possibility of benefit from further experiments with A.
The authors should check to be sure that the terms blood samples, plasma and serum are always used appropriately throughout the abstract and text.
Introduction: some sentences can be made less passive. example 1st paragraph
>>>> A appears to be the most important alkaloid isolated from the plant, its structural formula is shown in Fig 1. ... While it produced a general inhibition of antibody production lymphocyte proliferation was stimulated (Xia and Wang, 1997). These pharmacological properties suggest a potential use in the treatment of viral myocarditis against virus B that could be studied in experiments in cell culture and animals.
>>>The authors should check the entire manuscript for spelling errors (example given: in your text alkaloid is incorrectly spelled alkaloid)
>>>The authors should read the guidelines to the authors and not include the first name of the authors being cited in the text. In the reference section the first name should be abbreviated as shown in the guideline to authors (thus the earlier text reference should be (Liu et al., 2003)and the remaining one should be (Chen et al., 2002)
>>>>>The authors instead of directly answering the first complex question of reviewer #1 may include the three questions as future research aim in the discussion section.
>>>>>>Rather than redrawing figure the authors may choose to amend the wording of the statistical analysis section to state that the result of tables are means +-SEM and for figures are +- SD.
>>>>> reviewer #1 comment number 8 and reviewer # 2 comment 3 might be satisfied by inclusion of a representative photo of cells and heart showing CPE. Remember most readers of the journal have never seen what you are trying to describe.
Because I think that you can deal with all of the points raised I am hoping to see a revised manuscript that you have carefully checked for errors. If you have questions or do not know how to respond to any of the points raised please contact me at [e-mail] Joseph Bahl, PhD Editor 2 Life Sciences
作者回复信原稿：
Dear Dr. Bahl,
I’m （注：正式信函不要简写）very appreciate （注：不适合作为给编辑回信的开始，同时有语法错误）for your comments and suggestions.
I （注：实际上是学生做的）have conducted in vivo antivirus experiments again （注：要表明是应审稿人或编辑建议而作）. Mice were sacrificed on 15 days and 30 days after infection. Death rate, heart weight to body weight ratio (HW/BW), virus titers and pathologic slices （注：用词错误）were calculated（注：用词不当）. Production of mRNA of IL-10, IFN-γand TNF-αwere （注：语法错误）measured by RT-PCR.
I have revised this manuscript and especially paid much attention to your comments and suggestions. I would like to re-submit it to LIFE SCIENCE. Title of manuscript has been changed to “The antivirus effects of A against virus B and its pharmacokinetic behaviour in SD rats serum” to make it more clear and smooth.
Answers to Reviewers’ questions were as follows: （注：可附在给编辑的回复信后）
Reviewer #1:
XXXXX
Reviewer #2:
XXXXX
Editors note and suggestions:
Title: Re-write the title to read more smoothly in contemporary English
Answer: I have rewrite the title to “The antivirus effects of A against virus B and its pharmacokinetic behaviour in SD rats serum” to make it more clear and smooth（注：多处语法错误）.
Abstract: Re-write the abstract to read more smoothly.
Answer: I have revise the abstract carefully to make it more smooth and informative（注：语法错误）.
The authors should check to be sure that the terms blood samples, plasma and serum are always used appropriately throughout the abstract and text.
Answer: I have paid attention to this question and it is clearer （注：不具体）.
Introduction:
some sentences can be made less passive.
Answer: I have revise the whole paper to make sentences less passive and obtained help of my colleague proficient in English （注：语法错误，句子不通顺）.
The authors should check the entire manuscript for spelling errors
Answer: I’m very sorry to give you so much trouble for those spelling errors （注：不必道歉，按建议修改即可）. I have carefully corrected them.
The authors should read the guidelines to the authors and not include the first name of the authors being cited in the text. In the reference section the first name should be abbreviated as shown in the guideline to authors (thus the earlier text reference should be (Liu et al., 2003) and the remaining one should be (Chen et al., 2002)
Answer: I changed the style of references.
Rather than redrawing figure the authors may choose to amend the wording of the statistical analysis section to state that the result of tables are means +-SEM and for figures are +- SD.
Answer: （注：作者请编辑公司帮回答）
reviewer #1 comment number 8 and reviewer # 2 comment 3 might be satisfied by inclusion of a representative photo of cells and heart showing CPE. Remember: most readers of the journal have never seen what you are trying to describe.
Answer Thank you for your suggestions. I have supplemented pictures of cardiac pathologic slices in the paper (Fig2).
I have to apologize for giving you so much trouble because of those misspelling and confusing statements （注：一般不是延误或人为失误，不必轻易道歉，按建议修改即可）. Your comments and suggestions really helped me a lot. I have put great efforts to this review. I wish it can be satisfactory.
If there’s （注：正式信函不要简写）any information I can provide, please don’t hesitate to contact me.
Thank you again for your time and patience. Look forward to hear （注：语法错误）from you.
Yours Sincerely
Xxxx Xxxx (通讯作者名)
建议修改稿：
Dear Dr. Bahl,
Thanks you very much for your comments and suggestions.
As suggested, we have conducted in vivo antivirus experiments. Mice were sacrificed on 15 days and 30 days after infection with virus B. Mortality, heart weight to body weight ratio (HW/BW), virus titers and pathologic scores were determined. In addition, mRNA expression of IL-10, IFN-γ and TNF-α were measured by RT-PCR.
We have revised the manuscript, according to the comments and suggestions of reviewers and editor, and responded, point by point to, the comments as listed below. Since the paper has been revised significantly throughout the text, we feel it is better not to highlight the amendments in the revised manuscript （正常情况最好表明修改处）.
The revised manuscript has been edited and proofread by a medical editing company in Hong Kong.
I would like to re-submit this revised manuscript to Life Sciences, and hope it is acceptable for publication in the journal.
Looking forward to hearing from you soon.
With kindest regards,
Yours Sincerely
Xxxx Xxxx (通讯作者名)
Replies to Reviewers and Editor
First of all, we thank both reviewers and editor for their positive and constructive comments and suggestions.
Replies to Reviewer #1:
Xxxxx （略）
Replies to Reviewer #2:
Xxxxx （略）
Replies to the Editors note and suggestions:
Title: Re-write the title to read more smoothly in contmeporary English
Answer: I have rewrite the title to “The antivirus effects of Sophoridine against Coxsackievirus B3 and its pharmacokinetics in rats” to make it more clear and read more smoothly.
Abstract: Re-write the abstract to read more smoothly.
Answer: I have rewritten the abstract to make it more informative and read more smoothly.
The authors should check to be sure that the terms blood samples, plasma and serum are always used appropriately throughout the abstract and text.
Answer: I have paid attention to this issue, and they are now used appropriately throughout the abstract and text in the revised manuscript.
Introduction:
some sentences can be made less passive.
Answer: I have revised the whole paper to make sentences less passive with the help of the editing company.
The authors should check the entire manuscript for spelling errors
Answer: This has been done by us as well as the editing company.
The authors should read the guidelines to the authors and not include the first name of the authors being cited in the text. In the reference section the first name should be abbreviated as shown in the guideline to authors (thus the earlier text reference should be (Liu et al., 2003) and the remaining one should be (Chen et al., 2002)
Answer: I have changed the style of references according to the journal.
Rather than redrawing figure the authors may choose to ament the wording of the statistical analysis section to state that the result of tables aremeans +-SEM and for figures are +- SD.
Answer: SD has been used throughout the text, and shown in the Figs. 3 and 4 in the revised manuscript.
reviewer #1 comment number 8 and reviewer # 2 comment 3 might be satified by inclusion of a representative photo of cells and heart showing CPE. Remember: most readers of the journal have never seen what you are trying to describe.
Answer: Thank you very much for the suggestion. I have added pictures of cardiac pathologic changes in the revised manuscript (Fig. 2). 论文题目： Clinical implications of XXXX (一种病理指标) in X cancer
所投杂志：BMC Cancer.
结果：这次大修后被接受发表（同时编辑在接受信中提出课题是否得到伦理委员会同意的问题。作者在论文适当地方加上了有关陈述）
审稿人内容（有删节）：
Reviewer's report
Clinical implications of XXXX (一种病理指标) in X cancer
Version: 1 Date: 12 June 200X
Reviewer: XXXX XXXX (A Japanese Reviewer)
Reviewer's report:
General
-------------------------------------------------------------------------------
Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached)
1. XXXXX.
2. XXXXX.
3. XXXXX.
4) The clinico pathological parameters examined are reported in Table 1. Among the primary tumor characteristics, the Authors consider the diameter, but ignore T stage. Consequently the T parameter is not considered in the multivariate analysis. In other studies, T stage has emerged as an independent factor. The Authors should therefore state the reason for their unusual choice. Nor is the number of metastatic nodes reported in this table. Moreover, for tumor differentiation, the Authors distinguish between two groups (differentiated vs undifferentiated), instead of between the usual 3 categories (G1, G2 and G3). I have never heard of the histological classification used by the Authors (massive, next and diffuse). They might therefore state their reasons for choosing it, providing a reference, if available.
---------------------------------------------
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct)
XXXXX.
-------------------------------------------------------------------------------
Discretionary Revisions (which the author can choose to ignore)
(None)
What next?: Reject because too small an advance to publish
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being published
[b]Statistical review: Yes, but I do not feel adequately qualified to assess the statistics.
作者原答: T stage is considered in the multivariate analysis, and some modification has been made in tumor differentiation and histological classification.
建议改答： We accept Dr. XXX comment (表明你对审稿人的欣赏和赞同). In the revised version of the manuscript, T stage has been added in the multivariate analysis, and description of tumor differentiation and histological classification has been modified; the histological classification in the original manuscript has been replaced by the generally accepted classification (Page 6, line 15; Table 4) (同意审稿人的建议，并根据其建议进行修改。同时指出在何处做了修改。).
加注：作者原回答与修改后的回答并无本质差别，正文中的修改也是一样的。但作者原回答会给审稿人“不太乐意”或“轻描淡写”的印象。因为审稿人花了122个单词来就此问题发表建议，而作者只用了20个。
修改后的回答，相信一开始就赢得审稿人的好感。你的回答不光是给审稿人看的，杂志编辑也会看（至少审稿人会这么认为），所以，审稿人会有种满足感（国外审稿人没有酬劳，得到作者和编辑的认可是他们审稿最主要的目的）。建议得到认可（当然，这里审稿人的确是正确合理的），而且作者还按其建议对文章进行修改，相信绝大多数审稿人是不会（不好意思）再拒绝修改稿的（所谓伸手不打笑面人）。当然，这篇文章起死回生、二审通过审稿关，关键是杂志编辑手下留情，给了作者再投(Re-submission)的机会。
有时，审稿人的建议得到作者认可，但作者无法按建议修改，尤其补做试验。这种情况将在以后举例说明。论文题目：Misdiagnosis of A (一种先天性疾病) as 某某 tumor: a case report
所投杂志：Neuro-Ophthalmology
投稿结果：大修，结果未知（前途未卜，因为该审稿人建议拒稿，但审稿人给作者机会）
审稿人审稿内容及作者原答和建议改答（有删节）：
Reviewer 2's report
审稿人问题1
The authors try to caution eye specialists and neurosurgeons not to do major orbital surgery on children without doing a dilated fundus examination with an indirect ophthalmoscope. In their case, once the correct diagnosis was made, by properly examining the eye, surgery was not necessary. A thorough pre-operat