硬脑膜动静脉瘘的介入诊断及治疗.ppt

单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,硬脑膜动静脉瘘的介入诊断及治疗,硬脑膜动静脉瘘（,DAVF),发生于硬脑膜及其附属结构如静脉窦、大脑镰、小脑幕上的异常动静脉分流,约占颅内动静脉畸形的,10%-15%,可见于任何年龄，成人多见,硬脑膜动静脉瘘（,DAVF),硬脑膜窦畸形伴动静脉瘘,新生儿或婴儿，常为巨大囊袋或硬膜湖，与其它窦或大脑静脉以缓流交通，多累及上矢状窦，常伴栓塞、闭锁或一侧颈内静脉球发育低下,婴儿型,DAVF,高流速，高流量，多灶性，表现为大的窦及多发的局部动静脉瘘和大的供血血管，常继发引起皮层软膜分流，直窦常缺如；静脉出口闭塞可引起颅压增高，脑室积水,成人型,DAVF,婴儿型,DAVF,多支供血动脉,静脉窦瘤样扩张,梗塞性脑积水,直窦缺如,骨皮质改变,女，,10,岁 进行性脑神经缺失（婴儿型,DAVF,）,CT,强化：上矢状窦扩张，脑皮质钙化，白质变薄,MR T1WI,：上矢状窦及窦汇巨大流空影，小脑扁桃体下移,成人型,DAVF,硬脑膜动脉,前颅窝,脑膜中动脉前支,筛前、后动脉,脑膜返动脉,蝶腭动脉,中颅窝,脑膜中,/,副动脉,颈内动脉下外侧干,咽升动脉脑膜支,后颅窝,椎动脉脑膜支,脑膜垂体干,枕动脉脑膜支,脑膜中动脉后支,咽升动脉脑膜支,大脑后动脉分支,小脑上动脉分支,小脑下后动脉分支,发病机制,DAVF,与手术、头外伤、感染、硬脑膜窦血栓形成、雌激素等因素有关，但确切发病机制不明,两种假说,“生理性动静脉交通”开放：,硬脑膜动静脉之间存“生理性动静脉交通,”,（,dormant channels),或“裂隙样血管”（,crack-like vessels,），某些病理状态使其开放，形成,DAVF,新生血管：,某些血管生长因子异常释放促使硬脑膜新生血管形成，致使,DAVF,形成,分型,按静脉引流方向分型：与临床表现及预后密切相关,按,DAVF,部位分型：与血供来源及治疗途径密切相关,静脉引流方向与病变部位相结合分型,按静脉引流方向分型,Borden classification,1 Venous drainage directly into dural venous sinus or meningeal vein,2 Venous drainage into dural venous sinus with CVR,3 Venous drainage directly into subarachnoid veins(CVR only),Cognard classification,I Venous drainage into dural venous sinus with antegrade flow,IIa Venous drainage into dural venous sinus with retrograde flow,IIb Venous drainage into dural venous sinus with antegrade flow and CVR,IIa+b Venous drainage into dural venous sinus with retrograde flow and CVR,III Venous drainage directly into subarachnoid veins(CVR only),IV Type III with venous ectasias of the draining subarachnoid veins,V Venous drainage into the perimedullary plexus,CVR=cortical venous reflux,（可能与静脉窦闭塞有关）,按,DAVF,部位分型,海绵窦,DAVF,横窦乙状窦,DAVF,小脑幕,DAVF,上矢状窦,DAVF,前颅窝,DAVF,边缘窦,DAVF,岩上,/,下窦,DAVF,舌下神经管,DAVF,临床表现,良性,DAVF,搏动性杂音,眼眶充血,颅神经麻痹,慢性头痛,无症状,侵袭性,DAVF,颅内出血,颅内高压,非出血局部神经缺失,血管性痴呆,死亡,Borden type 1,Cognard typeI/,a,Borden type 2/3,Cognard type IIb-,皮层静脉返流（,CVR),或深静脉引流是预后不良的重要因素,搏动性突眼,球结膜水肿和充血,眶周杂音,进行性视力下降,颅神经麻痹,杂音，耳鸣，头痛,眼部症状,颅内出血（少见）,杂音，耳鸣,颅内出血,中枢神经缺失,头痛,颅内出血,中枢神经缺失，痴呆,颅内出血,头痛,诊断,经颅多普勒：可探测血流动力学改变，特异性较低,CT,与,MRI:,对良性,DAVF,敏感性较低；对侵袭性,DAVF,，可显示异常血管，颅内出血，局部占位效应，脑水肿，脑积水，静脉窦血栓形成及颅骨骨质异常等征象,CTA,与,MRA,：可清楚显示异常增粗的供血动脉和扩张的引流静脉及静脉窦，对瘘口位置及“危险吻合”显示欠佳,诊断,DSA,供血动脉,瘘口位置,引流静脉,静脉窦扩张与闭塞,脑循环异常,Male,62 tentorial,DAVF,（,Cognard,）,The left lateral ICA angiogram shows a tentorial DAVF fed by an inferior marginal tentorial artery draining into a cortical vein,L-ICA,Male,49 DAVF of anterior cranial fossa,（,Cognard,）,The left lateral internal carotid arteriogram demonstrates a DAVF supplied by the anterior ethmoidal branches of the ophthalmic artery and the draining intracranial vein with a focal aneurysmal dilatation at the site of parenchymal hemorrhage,L-ICA,tentorial,DAVF,（,Cognard,）,R-ICA,术后,1,年,MR,示上矢状窦血栓形成，,3,年后自感颅内杂音，,MR,示脑表多发迂曲血管流空影；左侧颈外动脉造影侧位，左侧横窦,DAVF,伴,CVR,，同侧乙状窦闭塞,女，,37,肾移植术后，左横窦,DAVF,（,Cognard a+b,）,岩上窦,DAVF,（,Cognard),向脊髓静脉引流,右脑膜中动脉后支，右枕动脉脑膜支及右侧脑膜垂体干供血,R,ECA,造影：右侧海绵窦,DAVF,，引流至眼上静脉及皮层静脉,男，,58,右眼球结膜充血水肿,治疗,保守治疗,立体定向放射治疗,血管内介入治疗,外科手术,介入治疗策略,经动脉微粒栓塞（,TAE-,微粒）：,难以达到完全栓塞，通常用于缓解症状或辅助治疗,经静脉弹簧圈栓塞,(TVE),：,治愈性手段，必须致密栓塞，否则可使症状恶化；可并发静脉壁损伤，颅内出血,经动脉,NBCA/Onyx,栓塞,(TAE),：,用于复杂,DAVF,不能通过静脉途径栓塞时，完全栓塞率较高；可造成异位栓塞，对操作技术要求高,支架植入：,其支撑力可恢复静脉窦正常引流并可封闭位于静脉窦壁上的瘘口；远期效果待进一步观察,海绵窦,DAVF,保守,放疗,TAE,微粒,TVE,TAE,NBCA,海绵窦DAVF,经静脉途径是首选的治愈性的方法,经岩下窦入路（闭塞时亦可通过）,经眼上静脉入路,其它入路：岩上窦、对侧海绵窦、基底静脉丛,Spontaneous regression of a cavernous sinus,DAVF,T2WI image,shows multiple flow voids in the posterior cavernous sinus,Left ECA angiogram,shows a cavernous sinus dural AVF with posterior drainage into the inferior and superior petrosal sinuses,Follow-up MR image,shows resolution of the flow voids,L-ECA,Left ECA angiogram,shows a cavernous sinus DAVF draining mainly into the inferior,petrosal sinus and pterygopharyngeal plexus,Follow-up angiogram,obtained 3 months,later shows that the inferior petrosal sinus is occluded,and the dural AVF,now drains into the superior ophthalmic vein and the superficial middle cerebral vein.Although,the patients symptoms were unchanged,occlusion of,the DAVF was indicated,TVE of DAVF via an occluded inferior petrosal sinus,L,Superselective venogram,shows that the tip of the microcatheter has been introduced into the outlets to the superior ophthalmic vein,Left CCA angiogram,obtained after TVE shows complete occlusion of the DAVF,TVE of DAVF via an occluded inferior petrosal sinus,横窦乙状窦,DAVF,放疗,+TAE-,微粒,横窦乙状窦,DAVF,TVE,（可先栓塞供血动脉）,放疗,+TAE-,微粒,支架植入,+TAE-,微粒,+,放疗,TVE,避免栓塞正常皮层静脉引流系统,横窦乙状窦,DAVF,TVE,（可先栓塞供血动脉）,支架植入,受累静脉窦及返流皮层静脉近端必须致密栓塞，以防再通致脑出血,横窦乙状窦,DAVF,TVE,（手术入路、经闭塞静脉窦入路、经皮层静脉入路）,TAE-NBCA,手术切除（可先栓塞供血动脉）,操作难度大，要求技术高,The lateral left ECA angiogram shows a DAVF of the transverse sinus with CVR and occlusion of the ipsilateral sigmoid sinus.A transvenous approach via the contralateral transverse sinus allowed selective catheterization of a parallel channel.Venography in this parallel channel shows the veins that were draining the fistula,Conversion of an aggressive DAVF to a benign(G3),This parallel channel was embolized with a combination of platinum coils and Hydrocoil A control left ECA arteriogram shows that the CVR was eliminated,although the fistula persists,Conversion of an aggressive DAVF to a benign(G3),The venous phase of the lateral CCA angiograms before and after treatment,we see that these cortical veins can participate in the venous drainage of the brain after disconnection,难以完全治愈时，可将侵袭性,DAVF,转化为良性,DAVF,Conversion of an aggressive DAVF to a benign(G3),Early arterial phase left CCA angiogram shows a transverse-sigmoid sinus DAVF.Late arterial phase left CCA angiogram shows that the left sigmoid sinus is occluded and the dural AVF drains mainly into cortical veins and the posterior condylar vein.Superselective venogram shows a microcatheter that has been advanced via the posterior condylar vein into the affected sinus,Recanalization of a transverse-sigmoid sinus DAVF after TVE,Left CCA angiogram obtained after TVE shows disappearance of the AVF.CT scan obtained 2 months after TVE shows a massive hemorrhage in the left temporal lobe.Left common carotid angiogram shows recanalization of the dural AVF at the retrograde cortical drainage outlet,Recanalization of a transverse-sigmoid sinus DAVF after TVE,可能与栓塞不致密有关,小脑幕,DAVF,只经软脑膜静脉引流,Cognard III/IV,，,;Borden 3,侵袭性,DAVF,，颅内出血风险大,治疗难度大,老年及一般状况差的患者可考虑放射治疗,Treatment Options for Tentorial Dural AVFs,Treatment Option*,Results,Radiation therapy,Complete occlusion(50%60%),Intervention,TAE with,n,-butyl-2-cyanoacrylate,Complete occlusion(50%100%),TVE,Complete occlusion(90%100%in,few case reports),Surgery(disconnection of,Complete occlusion(100%),leptomeningeal venous drainage),*,Surgery and TAE with n-butyl-2-cyanoacrylate are equal in terms of potential risk and technical difficulty;they are more potentially risky and technically difficult than radiation therapy and less so than TVE.,tentorial dural AVF,（,Cognard IV,）,Left ECA angiogram,shows a tentorial dural AVF,with leptomeningeal-cortical venous drainage and venous ectasia,Lateral radiograph,shows the planned,radiation field,Left CCA angiogram,obtained 8 months after radiation therapyshows complete obliteration of the tentorial dural AVF,Male,62,presented with a brain stem hemorrhage,The left ICA angiogram shows a DAVF fed by an inferior marginal tentorial artery draining into a cortical vein.Using a transvenous approach catheterization of the venous pouch was feasible.Coils were deposited within the cortical vein and the venous pouch,上矢状窦,DAVF,发生与上矢状窦血栓形成密切相关,经静脉途径栓塞困难，常需经手术入路静脉窦栓塞或手术治疗,部分病例（瘘口较大）可经动脉行静脉窦栓塞（静脉窦无正常静脉引流）,Treatment Options for Superior Sagittal Sinus Dural AVFs,Treatment Option*,Results,Radiation therapy Unknown,Intervention,TAE with particles Complete occlusion(rare),TVE Complete occlusion(90%100%),TAE with n-butyl-2-cyanoacrylate Complete occlusion(90%100%),Transarterial sinus catheterization Complete occlusion(100%in case,and coil embolizatio reports),Surgery(sinus isolation or resection)Complete occlusion(90%100%),combined with intervention,*,Treatment options in decreasing order of potential risk and technical difficulty are TAE with,n,-butyl-2-cyanoacrylate,surgery,TVE,and radiation therapy.,Superior sagittal sinus dural AVF,Right ECA angiogram,shows a dural AVF with cortical reflux and occlusion of the superior sagittal sinus,Right ECA angiogram,obtained during transarterial sinus embolization shows a microcatheter that has been advanced into the superior sagittal sinus via the right middle meningeal artery,Right ECA angiogram,obtained after embolization shows obliteration of the AVF,前颅窝,DAVF,多由双侧眼动脉的筛动脉供血,经软脑膜静脉引流,Cognard III/IV;Borden 3,侵袭性,DAVF,，颅内出血风险大,外科手术相对安全，疗效好,Treatment Options for Anterior Fossa Dural AVFs,Treatment Option*,Results,Radiation therapy Unknown,Intervention,TAE with n-butyl-2-cyanoacrylate Complete occlusion(90%100%in,a few case reports),TVE with a retrograde cortical Complete occlusion(90%100%in,venous approach a few case reports),Surgery(disconnection of,Complete occlusion(100%),leptomeningeal venous drainage),*,TVE and TAE with,n,-butyl-2-cyanoacrylate are equal in terms of potential risk and technical difficulty;they are more potentially risky and technically difficult than surgery,which in turn is more so than radiation therapy.,Anterior fossa dural AVF,Unenhanced CT scan,shows intracranial hemorrhage at the frontal base,Left ICA angiogram,shows a dural AVF that is fed by the ethmoidal artery and drains into the,leptomeningeal vein,which demonstrates varices,Left ICA angiogram,obtained after clipping of the draining vein shows disappearance of the AVF,L-ICA,男，,39,前颅窝,DAVF,右颈内动脉造影：,前颅窝,DAVF,，由增粗的筛前动脉供血，向前引流至上矢状窦，向深部引流至岩上窦,左颈内动脉造影：,左侧筛前动脉参与供血,R-ICA,L-ICA,男，,39,前颅窝,DAVF,经上矢状窦置入微导管，颈内动脉证实微导管头位于引流静脉瘤样扩张处，应用两枚电解弹簧圈栓塞,R-ICA,男，,39,前颅窝,DAVF,R-ICA,L-ICA,参考文献,Hiro Kiyosue,Yuzo Hori,Mika Okahara,et al.Treatment of Intracranial Dural Arteriovenous Fistulas:Current Strategies Based on Location and Hemodynamics,and Alternative Techniques of Transcatheter Embolization1.RadioGraphics 2004;24:16371653.,Robert W.Hurst,Robert H.Rosenwasser.INTERVENTIONAL NEURORADIOLOGY.335-351,谢谢！,