睡眠肽LACTIUM_General_presentation中英文.ppt

Titre de page,Premier niveau,Deuxime niveau,Troisime niveau,Texte courant,*,General presentation,介绍,Stress management through nutrition,减压,2,IDI Overview,公司概述,Turnover:235m,营业额：,2.3,亿欧元,Export sales:70%,出口销售额：,70%,Commercial presence in more than 120 counties,产品广销,120,个国家,Annual production:100,000MT of dairy ingredients,年生产量：,10,万吨乳制品,Range of products:dairy powders,functional systems,milk proteins,产品范围：乳制品，功能性食品原料，乳蛋白,3,Introduction,简介,Scientific evidence,科学依据,Regulatory status,法规现状,Technological data,技术数据,Marketing potential,潜在市场,Conclusion,结论,Table of contents,目录,June 2008,Introduction,简介,5Introduction,What is stress?,压力是什么？,“Without stress there would be no life”,Hans Selye,压力无处不在,Stress is not a disease but a,stimulus,.It is an,unavoidable natural reaction,of the body and the mind,to everyday tension and pressure,.,压力并不是一种病而是对人的一种刺激，它是对人体、人脑的紧张状态不可避免的一种自然反应。,Stress is both -,universal,:everyone is subject to stress,压力是普遍的：每个人都容易感觉有压力,-,individual,:people respond to stress in different ways.,压力又是个别的：人们对待压力的反应各不相同,When stress is not well-managed,instability is generated and,stress-related disorders,appear.,当压力没有得到很好的控制时，不稳定性将会产生，压力有关的失调紊乱也会出现。,Consumers cannot or do not want to stop stress,but rather,regulate its symptoms.,人们通常不可避免产生压力（或则希望有些压力），但希望可以调节它的症状。,6,Lactium,was developed by Ingredia Nutritionals scientists,in collaboration with research institutes since 1990.,自,1990,年起，,Lactium,由,Ingredia,营养公司与研究所一起研发的。,The baseline of this research was the simple observation of,the calm state of a baby after breastfeeding,.,研究的基准是观察母乳喂养的婴儿的情绪状态。,Researchers wanted to find a,relationship,between the consumption of milk and this soothing state.,研究者希望能找出饮用牛奶与平复情绪之间的关系。,After many years of research and several clinical and toxicological studies,they succeeded in identifying within a milk protein,a bio-peptide with natural relaxing properties,that can be isolated thanks to a typical hydrolysis.,经过多年的研究、若干次临床试验和毒理性试验，他们成功的鉴定了在牛奶蛋白中,天然十缩氨酸（是一种孤立的水解蛋白）具有减压（令人心情放松）的生理活性。,How a baby discovered Lactium,Lactium,是如何被婴儿发现的,Introduction,7,Lactium,is a,milk protein hydrolysate,that,contains a bioactive decapeptide,with,relaxing properties,.,Lactium,是牛奶蛋白的水解产物，它包含了具有生物活性的十缩氨酸，其具有令人放松的作用。,The adult enzymatic system cannot release this bioactive peptide anymore.That is why taking,Lactium,is,the natural solution to calm down,.,由于成人体内的酶系统不能释放出具有生物活性的十缩氨酸，就是为什么服用,Lactium,是一种让人减压的天然方法。,Lactium,has been clinically proven to be,efficient on stress symptoms,reduction,.,Lactium,拥有临床研究证明其对减轻压力上具有功效。,Lactium,does not suppress stress factors,并非是抑制压力产生,but it,decreases stress-related symptoms,而是减轻与压力有关的症状,and helps cope with occasional and everyday stress.,也是帮助您面对偶然或每天的压力,Lactium,is a,unique,natural and efficient solution,to help consumers deal with,stress-related symptoms,.,Conformation of the bioactive decapeptide,(,-casozepine),What is Lactium,?,Introduction,8,How does Lactium,work?,如何起效？,Lactium,s action:,起效,Positioning on stress symptoms:prevention or improvement of:,对于压力症状的定位：预防还是改善,Chronic pain,due to chronic stress,长期病痛导致长期性压力,Sleep disorders,睡眠失调,Digestive disorders,due to occasional stress,食欲不调导致偶然性压力,Mood disorders,情绪失控,Impaired memory,&,concentration,记忆力或注意力下降,Relationship troubles,e.g.libido decrease,相关性困扰如：性欲下降,Weight management,体重控制,State of tension,e.g.quit smoking,紧张如：戒烟,STRESS RELEASE,压力的释放,Occasional stress,:exams,diet,偶然性压力：考试，节食,Chronic stress,:everyday life,长期性压力：日常生活中,Introduction,9,Lactium,is one of the few ingredients that have received a,French health claim authorization,from the French Safety and Control Administration DGCCRF(French General Directorate for Competition Policy,Consumer Affairs and Fraud Control)approved by the AFSSA(French Food Safety Agency):,Lactium,是少数通过了法国安全控制监督局健康认证的一个食品原料（法国：竞争、消费和抑制欺诈总理事会食品管制）,peut modrer la rponse tensionnelle au stress,notamment chez les personnes particulirement sensibles.,can moderate the tensional response to stress,in particular for hypersensitive persons.,它可以平复由压力产生的紧张情绪，特别是对于过分敏感的人群,.,Moreover,Lactium,is on the,EHPM/CIAA list,waiting to receive a,European health claim authorization,from the EFSA(European Food Safety Agency)in 2010(EEC Regulation 1924/2006 art.13).As it is considered,level 5,Lactium,has the highest chances of receiving this European health claim authorization.,而且，已在,Lactium,EHPM/CIAA,名单中（等待,EFSA,欧洲食品安全局的健康认证），在此名单中,Lactium,是最有希望通过认证的。,Lactium,also benefits from a,Korean health claim authorization,:,Lactium,通过了韩国的健康认证,Milk hydrolysate(,Lactium,)can release the tension by stress,Australian TGA authorization,澳大利亚治疗用品管理局认证,Lactium,:acknowledged efficacy,功效被承认,Introduction,June 2008,Scientific evidence,科学依据,11,Scientific evidence,Lactium,:proven efficacy on humans,人体实验证明有效性,6 clinical studies,carried out on,234 volunteers,通过了,6,次临床研究（,234,名志愿者）,All clinical trials were performed according to Good Clinical Practices Guidelines and under official ethical,committees scrutiny.They were all performed on healthy human volunteers,using validated biological indicators,and randomized,double-blind and placebo-controlled procedures.,Necker Hospital,1999:,1999,年,Necker,医院,9 volunteers,9,名志愿者,150 to 1250mg of,Lactium,as a single oral intake,一次性服用,150-1250mg,Lactium,1 day period,1,天,Optimed,1999:,1999,年,Optimed,24 volunteers(12 males+12 females)20 to 35 years old,20-35,岁的,24,名志愿者（男女各,12,名）,150mg of,Lactium,as a daily oral intake,每日口服,150mg,Lactium,15 days period,15,天,Necker Hospital,2000:,2000,年,Necker,医院,42 male volunteers 18 to 35 years old,42,名男性志愿者（,18-35,岁）,2 x 400mg of,Lactium,the first day and 1 x 400mg of,Lactium,the second day,第一天口服,2,次每次,400mg,Lactium,，第二天口服,1,次,400mg,Lactium,2 days period,2,天,12,Scientific evidence,CRSSA,2001:,52 volunteers (25 males+27 females)18 to 40 years old,52,名志愿者（年龄,18-40,岁，,25,名男性,27,名女性）,150mg of,Lactium,as a daily oral intake,每日口服,150mg,Lactium,30 days period+12 days wash-out,服用,30,天，后,12,停止服用,Proclaim,2003:,63 female volunteers 18 to 61 years old 63,名女性志愿者,年龄,18-61,岁,150mg of,Lactium,as a daily oral intake,日口服150mg,Lactium,30 days cross-over+3 weeks wash-out 30,天交叉服用，后,3,周停止服用,IGHD,2006:,44 mixed volunteers 25 to 40 years old 44,名志愿者,-,年龄,25-40,岁,150mg of,Lactium,as a daily oral intake,每日口服,150mg,Lactium,4 weeks period+1 week wash-out,连续,4,周，后,1,周停止服用,Lactium,:proven efficacy on humans,人体实验证明有效性,13,Scientific evidence,1.,Evaluation of Lactium,effect on basal metabolism and side effects at different dosages,.,Necker Hospital,1999.,评估服用不同剂量的,Lactium,在人体中的新陈代谢及其副作用。,(,150 to 1250mg of,Lactium,administered,p.o,.1 day-9 volunteers),（,1,天服用,150-1250mg,Lactium,-9,名志愿者）,L,actium,has,no side effects on humans,even at high dosages(1250mg).,证明即使在服用很高剂量（,1250mg,）的,Lactium,对人体无副作用。,2.,Evaluation of Lactium,anti-stress effect,.Optimed,1999.,评估的,Lactium,抗压作用,(150mg of,Lactium,p.o,.15 days 24 volunteers)-Stress induced by stroop test.,（,15,天服用,150mg,Lactium,-24,名志愿者）,-,通过实验诱发压力,Lactium,decreases the anxietystate score,.,Lactium,可以减轻焦虑状态,Lactium,:proven efficacy on humans,人体实验证明有效性,14,3.,Lactium,anti-stress effect in a short-time study,.Necker Hospital,2000.,研究,Lactium,短期内对于抗压的效果,(,Lactium,p.o,.-1,st,day:400mg x 2,2,nd,day:400mg x 1 42 volunteers)-Stroop test.,（第一天服用,2,次每次,400mg,，第二天服用,1,次每次,400mg-42,名志愿者）,Lactium,significantly moderates,the,SBP,(,-31.9%,vs.placebo),DBP,(,-28.9%,vs.placebo)and,blood cortisol,response to stress(,-21.3,%after 3h).,Lactium,有效地调节了收缩压,SBP(-31.9%,比空白组,),、舒张压,DBP,(-28.9%,比空白组,),和血液中的皮质醇,(,服用后,3,小时下降,21.3%),*,*,Unpaired t-test(2 tailed)*p 0.01 *p 0.05,-31.9%,-28.99%,Scientific evidence,Paired t-test(2 tailed):*p 2000mg/kg,.,急性毒性实验（按每公斤体重服用,2000mg,，相当于有效剂量的,130,倍,-1,天），,Lactium,的半数致死率大于,2000mg/kg,。,Sub-chronic,(40,200 and 1000mg/kg-28 days)and,chronic toxicity,(40,250 and 1000mg/kg-91 days):,no observable toxic effects even at 1000mg/kg/d,.,潜在的长期性毒性（按每公斤体重服用,40,，,200,，,1000mg-28,天），长期性毒性（按每公斤体重服用,40,，,250,，,1000mg-91,天）：观察表明即使在高剂量下也无毒性。,Further studies,进一步研究,No mutagenicity:no mutagenic effect observed in vitro in mammalian cells,either with or without metabolic activity.,无诱变性：体外哺乳动物细胞实验,No teratogenicity(15mg/kg p.o.-all gestation long):neither general nor visceral malformation in young rats.,无致畸性（孕期中服用剂量每公斤体重,15mg,）,No behavioral toxicity(15mg/kg p.o.-all gestation long):neither change in gestating rats,nor alteration in the development of their broods.,无行为毒性（孕期中服用剂量每公斤体重,15mg,）,Scientific evidence,23,and no side effects,无副作用,p.o.administration of Lactium on rats showed,动物实验,:,No memory loss(Social memory test),记忆损伤,No habituation(Conditioned defensive burying test(CDB),无依赖性,No addiction(Conditioned place preference test),无上瘾性,No sedation(No weight increase i.e.no decrease of physical activity),无镇静（不增加体重，不减少体能活动）,No disinhibition(CDB and Elevated plus maze(EPM)models),无去抑制,Neither psychological nor somatic side effects tested on rats and confirmed on humans through the Hopkins symptom checklist.,动物（老鼠）实验表明无心理或生理上的副作用，人体通过贺普金斯症状检核表,Neither loss of alertness nor muscular reactivity tested on rats and confirmed on humans through the Thayer questionnaire.,动物（老鼠）实验表明无肌肉性反应，人体通过赛耶调查,Lactium is a milk protein hydrolysate so it is hypoallergenic.It contains little lactose(1%)and therefore presents low risks of lactose intolerance.,它是水解牛奶蛋白，低变应原。含有少量乳糖（小于,1%,），出现乳糖不耐症的几率较小,Lactium,shows,no toxicity,and,no side effects,.,Scientific evidence,Regulatory status,法规现状,25,Efficacy recognized by Authorities,权威认可,Lactium,is one of the few ingredients that have received a,French health claim authorization,from the French Safety and Control Administration DGCCRF,approved by the AFSSA:,Lactium,是少数通过了法国安全控制监督局健康认证的一个食品原料,can moderate the tensional response to stress,in particular for hypertensive persons.,Moreover,Lactium,is on the,EHPM/CIAA list(level 5),waiting to receive a,European health claim authorization,from the EFSA in 2010.,而且，已在,Lactium,EHPM/CIAA,名单中（等待,EFSA,欧洲食品安全局的健康认证），在此名单中,Lactium,是最有希望通过认证的。,Lactium,also benefits from a,Korean health claim authorization,:,Lactium,通过了韩国的健康认证,Milk hydrolysate(,Lactium,)can release the tension by stress,Australian TGA authorization,澳大利亚治疗用品管理局认证,A food grade ingredient,食品级原料,Europe,:,not classified as Novel food,USA,:-,GRAS(Generally Recognized As Safe,公认无毒,)status,FDA approved(peptone category,蛋白目录,),-NDI(New Dietary Ingredient,新膳食原料,)approved(#rpt242),A clean label,清晰的标签,Europe and Asia,:milk protein hydrolysate,水解乳蛋白,USA,:,caseinhydrolysate,水解酪蛋白,Regulatory status,Lactium,:a clear and well-defined regulatory status Lactium,:,清晰准确的法规现状,26,Worldwide patents,世界专利,Ingredia Nutritional owns a,patent on the decapeptide and its activity,including products containing it:,Ingredia,营养公司拥有十缩氨酸与产品的专利,European title=Utilisation dun dcapeptide activit de type benzodiazpine pour la prparation de mdicaments et de complments alimentaires(Use of a decapeptide with a benzodiazepine activity for the preparation of medicaments and dietary suplements),EP 0714910B1,Nov.30,1995,.,US title=Use of a decapeptide with benzodiazepine-type activity for preparing medicines and food supplements,Patent Number 5,846,939,Dec.8,1998,.,Japan title=Use of a decapeptide with benzodiazepine-type activity for preparing medicines,Patent Number 3973244,June 22,2007.,Regulatory status,27,and awards,荣誉,Regulatory status,June 2008,Technological data,技术数据,29,Lactium,Casein hydrolysate containing,a bioactive decapeptide,酪蛋白水解物包含了生物活性的十缩氨酸,s1,casein,酪蛋白,Skimmed milk,脱脂奶,protein separation,蛋白分离,tryptic hydrolysisheat treatment,+drying,Peptide,Bioactive peptide,Technological data,Lactium,:a food grade process,Lactium,is a milk protein hydrolysate,containing a,bioactive decapeptide,that results from an enzymatic digestion similar to the babys one.,30,Ingredia S.A.is,ISO 9001:2000 certified,and has been following,HACCP,guidelines since 1992.,Each batch is controlled.Tests ensure a,standardized,homogenous,and,safe,content by,每批监控，实验确保标准化，质量稳定，安全,:,Physical analysis(color,taste,),物理检测（颜色，味道,）,Chemical analysis(moisture,fat,protein,),化学检测（水分，脂肪，蛋白质,）,Microbiological analysis(E.Coli,Salmonella,),微生物检测（大肠杆菌沙门氏菌,）,Nutritional analysis(energy value,minerals,amino acid,),营养成分检测（能量，矿物质，氨基酸,）,The,bioactivity of,Lactium,is validated on each batch through 2 methods:,每批产品通过,2,个方法证明其生物活性,HPLC,(High Performance Liquid Chromatography),:to quantify and guarantee the active ingredient content.HPLC,：检测活性成分含量,CDB,(Conditioned Defensive Burying standardized test on rats),:to control the biological activity,of,Lactium,in vivo.,条件型电极包埋模型（老鼠实验）：检测体外生物活性,a,S1,-CN(f91-100),Lactium,:a controlled process for guaranteed quality,全程监控确保质量,Technological data,31,Developed to be,easily incorporated,in food or dietary supplements.,容易在食品和膳食补充中应用,Several references,adapted,to consumers needs.,多种文献支持,Water-soluble,at the recommended dosage.,水溶（推荐使用剂量）,pH-stable,(from 2 to 9)and,heat-stable,.PH,稳定（,2-9,），热稳定,No off-flavor,in applications(no bitterness).,无不良气味，无苦味,Perfectly adapted and effective in,different food matrices,可运用于多种食品形式,Functional foods,:,功能性食品,Dairy products Fermented milk Biscuits Beverage Chocolate Cereal bars,乳制品 发酵乳 饼干 饮料 巧克力 谷物棒,Dietary supplements,:,膳食补充,Capsules Softgels Tablets Sticks Gums,胶囊 软胶囊 片剂 棍状 凝胶,Several applications already tested,by Ingredia Nutritional(available on request).,多种形式已被运用,Recommanded dosage,有效剂量,:150mg/day,For a minimum program of 2 weeks,ideally 1 month,+additional dose during acute stress period.,连续,2,周，特别情况下,1,个月，也可加大剂量,Lactium,:flexible in applications,易于应用,Technological data,June 2008,Marketing potential,潜在市场,33,Zen,&,Slim,For a diet without snacking or bad mood.,Lactium,supports you during your diet by helping better manage your stress to control food craving.,帮助你控制由压力引起的食欲增加,Marketing potential,Lactium,:successful in applications*,成功案例,Good nights,Refreshing nights make effective days.,Thanks to,Lactium,you can improve your sleep quality and length.More relaxed and alert in the morning,you feel ready for a busy and challenging day.,优质睡眠确保你每日精神气爽、高效生活,可以改善你的睡眠质量，延长睡眠。让你第二天神清气爽，充满活力的迎接挑战。,*These,concepts and recipes are indicative information.They have no legal status.They are suggested without guarantee of compliance with country regulations.,34,Lactium,:successful in applications*,成功案例,Easy detox,No has never been so easy to say.,Tobacco detoxification is a nerve-racking stage of life.,Lactium,can help you successfully quit smoking by limiting stress and boosting your motivation.,当你为了戒烟而扰乱了你的日常生活，,Lactium,可以帮助你成功戒烟，并且减少你由戒烟引起的不安，使你充满活力。,Choco Relax,Your mood solution.,When life pressure reaches your emotional balance,Lactium,appears as an ideal solution to recover peace and wellness.,巧克力可以让你放松心情。当生活的压力超出了你的承受范围，,Lactium,是帮你恢复平静与健康的理想的选择。,35,Clear Mind,Clarify your mind in serenity.,Lactium,decreases the negative effects of stress upon intellectual functioning,especially during highly demanding periods.,让你保持头脑清新。,Lactium,可以减少因为压力而产生的负面影响。,Yog Cool,Recover your serenity and stand back from everyday stress.,Every morning,you feel tense because of your active way of life.,Lactium,helps you relax and preserves your quality of life.,