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1、单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,本幻灯片资料仅供参考，不能作为科学依据，如有不当之处，请参考专业资料。,Alzheimer,s Disease,阿尔茨海默症,第1页,Ronald Wilson Reagan,罗纳德威尔逊里根,第,40,任（第,49-50,届）美国总统 president,“I know Im on my way to the twilight.I know theres always a bright dawn ahead of the United states.Thank you,my friends.May G
2、od bless you forever.”,第2页,brief introduction,01,Pathogeny,Treatment,03,Clinical manifestation,02,Other,04,Catalog,第3页,brief introduction,1,第4页,What?,Alzheimers disease(AD)is a progressive neurodegenerative disorder.,临床症状,Clinical symptom,记忆障碍dysmnesia,失语aphasia,失认agnosia,执行功效障碍,e,xecutive dysfuncti
3、on,痴呆dementia,The disease usually begins after age 60,and risk goes up with age.,第5页,Two types,Alzheimers disease,(AD),65 years old,senile dementia,(SDAT),65 years old,第6页,Name,In 1906,AD is named,by,Dr.Alois Alzheimer,a German doctor.,Dr.Alzheimer noticed changes in the brain tissue of a woman who
4、had died of an unusual mental illness.,He found abnormal clumps.Scientists also have found other brain changes in people with AD.,Nerve cells die in areas of the brain that are vital to memory and other mental abilities.,第7页,Clinical manifestation,2,第8页,Clinical manifestation,期,期,期,death,1-3,years,2
5、10,years,8-12 years,Mild dementia,Moderate dementia,Severe dementia,More women than men,7:54:6,Disease for up to 10-20 years,第9页,Degradation of memory and cognition,William Utermohlen,自画像,第10页,Degradation of memory and cognition,William Utermohlen is an American artist,in,1995,he was diagnosed with
6、 Alzheimers disease.Since then,he has decided to take advantage of the limited time available to retain memory and better understand himself through self portraits.,William insisted the,5,New Year paintings self portrait,until completely forgotten how to draw.From the use of skilled drawing,dark por
7、trayal of vivid features,to the same color,shape deformation,self portrait became more and more abstract(pictured above).,第11页,Degradation of memory and cognition,the effects of Alzheimers disease on the right parietal lobe of the brain are particularly severe,which directly affects the ability of t
8、he brain to visualize and develop the ability to draw pictures of the brain.said Dr.Bruce Miller,a neurologist.,His work became more abstract,may be the parietal function damaged,causing blindness.,What kind of changes have occurred in the brains of patients with dementia,which is not yet fully unde
9、rstood by the world s academia.,第12页,Pathogeny,Treatment,3,第13页,Pathogenesis hypothesis of AD,第14页,Pathogeny,Abnormal amyloid beta cell deposition in neurons,Abnormal phosphorylation of tau protein,vs,第15页,Beta amyloid(blue curve)and Tau protein(orange curve),Research papers published,in recent 30 y
10、ears,第16页,Treatment,increase the concentration of acetylcholine(Ach)in the brain,promoting survival of cholinergic neurons in the brain or improving their nerve conduction function,reducing the production or promoting degradation of beta amyloid,第17页,Other,4,第18页,Still Alice,Film,The film tells the story of Alice Howland in seriously,AD,but still strong and brave,.,The film won the eighty-seventh Oscar award,第19页,The Notebook,Memories of Tomorrow,第20页,Thankyou,第21页,
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