医学微生物英语教学大纲(6版).doc

Medical Microbiology
Introduction
• Microbiology is the biology of microorganisms that are small, simple structure and not directly visible to unaided eye. It is a bioscience for the study of the evolution, classification, morphology of microbes under certain definite conditions, the law of their life activities, and their interaction with human beings, animals or plants as well as with natural environment. Microorganisms are creatures that are not directly visible to the unaided eye, with dramatical biologic diversity. Viruses , bacteria, fungi, protozoa and some algae are all in this category. The medical microbiology is one of the essential basic sciences. It is the study of Biological characteristics of microorganisms and their relationships with human hosts

contents
1. Bological properties of microorganism 6h
2. Infection 3h
3. Immunity to microorganism infection 2h
4. Heredity and variation 3h
5. Medical microecology, Nosocomial infection, Disinfection and sterilization 2h
6. Diagnosis, prevention and cure of aetiology 1h
7. Pyogenic bacteria 2h
8. Enterobacteriaceae, Vibrios 3h
9. Anaerobes 1.5h
10. Bacteria infection through respiratory 1.5h
11. Bacteria infection through Zoonotic bacteria 2h
12. Respiratory Virus 2.5h
13. Enterovirus group 2.5h
14. Hepatitis Viruses 3h
15. Flavivirus Virus 0.5h
16. Hemorrhagic Fever Viruses 0.5h
17. Herpes Virus 1.5h
18. Retrovirus 1.5h
19. Other Viruses, Prion, 1.5h
20. Fungi 1.5h
21. Other microorganism 2h

Chapter Biological properties of microorganism
[Requirement]
Bacteria
1. Master the cell wall structure of bacteria and their functions
2. Master the special structure of bacteria and their functions
3. Master the following concepts :
1. plasmid 2. capsule 3. spore
4.L-form bacterium 5. lipopolysaccharide(LPS)
4. Understand the Metabolism of bacteria and their products
5. Understand the growth curve of bacteria
6. Understand the cell membrane, cytoplasm, nuclear material of bacteria
Virus
1. Master the chemical composition and function of viruses
2. Master the major feature of the replication cycle of viruses
3. Master the following concepts :
1. virion 2. interference 3.prion 4.defective virus(缺陷病毒) 5. abortive infection(顿挫感染)
4. Understand the characteristics of Viral Genetics.
5. Understand the effects of physical and chemical agents on viruses.

Fungus
1. Master the genearal characteristics of fungi.(真菌)
2. Understand the morphology and culture properties of fungi

[Class hour: 6 hour]
[Content]

Bacteria
1. detailed explain the conception of bacteria, structure, special structure, Grams’stain and chemical composition of bacteria.
2. 2. general explain bacterial nutrient materials, bacterial growth and reproduction ang bacterial metabolism.

Virus
3. detailed explain the conception of virus ,Structure and Chemical Composition and classification of virus.
4. intensively explain the Viral Replication cycle（复制周期） adsorption (吸附) ,
penetration（穿入）,uncoating（脱壳）,biosynthesis（生物合成）,assembly and release（装配和释放）.
3. intensively explain Unnormal multiplication.
4. general explain the Viral Genetics Mutations;Effects of Physical andChemical Agents on Viruses.

Fungus
1. general explain characteristics morphology（形态）, properties,Classification of fung

Chapter Infection
[Requirement]
1. Master the mechanism of bacterial virulence
2. Master the resource, chemical composition and pathogenic mechanism of exotoxin and endotoxin
3. Master the the pathways of viral infections and the viruses which can result in vertical infection .
4. Master the pathogenesis of viral infection and the oncogenic virus associated with human tumors.
5. Master the the characteristics of immunity against virus infection
6. Master the the antiviral activity of IFN.
7. Master the following concepts :
1. vertical transmission 2. latent infection 3. slow virus infection
4.Interferon (IFN) 5. neutrilizing antibody 6. CPE 7.infection 8.exotoxin 9. endotoxin
8. Understand the classification of IFN and the production of IFN.
9. Understand the resource, route and type of bacterial infection.
10. Understand the morphology and culture properties of fungi
[Class hour: 3 hours ]
[Content]
1. intensively explain pathogenesis of bacterial Infection.
2. detailed explain the resource, chemical composition, pathogenic mechanism.
3. detailed explain the the pathways of viral infections and the type of viral infection,Immunity against virus infection.
4. intensively explain Pathogenesis of Viral Infection.
5. general explain Epidemiology, examination methods, prevention and treatment, Pathogenicity and immunity diagnosis of fungi

Chapter Heredity and Variation
[Requirement]
1. Master the concept, main characteristic of plasmid and important plasmid of associated mecial.
2. Master the main mode of gene transfer and recombination.
3. Master the following concepts :
1. Plasmid 2.phage 3.transformation 4.conjugation 5.transduction 6.lysogenic conversion
4. Understand the principle of heredity and variation
5. Understand the variation phenomenon of bacteria.
6. Understand the medical significance of microbic heredity and variation

[Class hour: 3 hours ]
[Content]
1. general explain the principle of heredity and variation
2. detailed explain the variation phenomenon of bacteria.
3. detailed explain the mode of phage.
4. intensively explain the variation mechanism of bacteria.
5. explain the heredity and variation of virus.
6. general explain the medical significance of microbic heredity and variation

Chapter Medical microecology, Nosocomial infection, Disinfection and sterilization
[Requirement]
1. Master the concept of normal flora and conditioned pathogen
2. Master the pathogenic condition and main characteristic of conditioned pathogen.
3. Master the following concepts :
1.normal flora 2.conditioned pathogen 3.opportunistic infection 4.disinfection 5.sterilization 6.asepsis 7.antiseptic technique
4. Understand the concept and research contents of medical microecology.
5. Understand .
6. Understand the physics methods and chemical methods of disinfection and asepsis.
[Class hour: 3 hours ]
[Content]
1. detailed explain conditioned pathogen and opportunistic infection.
2. explain the concept the mian microorganism, risk factors and prevention and therapy of nosocomial infection.
3. detailed explain the concepts of disinfection, sterilization, asepsis and antiseptic technique
5. detailed explain moist heat sterilization.
6. explain chemical methods of disinfection and asepsis.

Chapter Diagnosis, prevention and treatment of aetiology
[Requirement]
1． Master announcements of specimen collection and laboratory diagnosis
2． Master the main process of detection of pathogen
3． Master the culture of virus
4． Understand the significance of serodignosis
5． Understand the examination methods of viral infection.

[Class hour: 1 hours ]
[Content]
1. explain bacteriological diagnosis and serological diagnosis
2. explain the diagnosis of virus
3. explain the dignosis of fungus

Chapter Pyogenic bacteria
[Requirement]
1. Master the pathogenic materials, mechanisms of coccus and its disease
2. Understand the common properties, examination methods, prevention and treatment of coccus
[Class hour: 3 hours ]
[Content]
1. intensively explain the pathogenicity of Staphylococcus and Streptococcus
2. intensively explain the pathogenicity of S. pneumoniae and Neisseria
3. explain the common properties, examination methods of coccus

Chapter Enterobacteriaceae, Vibrios
[Requirement]
1. Master the common properties of Bacterium entericum
2. Master the pathogenicity of Bacterium entericum
3. Master the biological characteristics and pathogenicity of V. choleraae
4. Understand the examination methods, prevention and treatment of Bacterium entericum
5. Understand the examination methods, prevention and treatment of V. choleraae
[Class hour: 3 hours ]
[Content]
1. intensively explain the main biological characteristics and pathogenicity of Shigella
2. intensively explain the main biological characteristics and pathogenicity of Salmonella
3. detailed explain laboratory examination of Bacterium entericum
4. detailed explain Widal test and its result decision
5. detailed explain the effect of cholera enterotoxin at pathogenesis

Chapter Anaerobes
[Requirement]
1. Master the biological characteristics and pathogenicity of C. tetani
2. Master how to use antitox and anatoxine at disease caused C. tetani
3. Understand the biological characteristics of C. perfringens
4. Understand pathogenic mechanism and characteristics of clostridial myonecrosis
5. Understand the pathogenesis of C. botulinum
[Class hour: 1.5 hours ]
[Content]
1. intensively explain the biological characteristics, pathogenicity, prevention and treatment of C. tetani
2. intensively explain biological characteristics, pathogenic mechanism and characteristics of clostridial myonecrosis
3. detailed explain pathogenesis of Clostridum
4. explain the the classification of anaerobic bacteria
5. explain the the classification, common properties, distribution of Non-spore-forming anaerobes
Chapter Bacteria infection through respiratory
[Requirement]
1. Master the biological characteristics, pathogenicity and immunity of Mycobacterium
2. Master the principle, method, result judgement and significance of tuberculin test
3. Master the biological characteristics, pathogenicity, immunity and treatment of C. dipheriae
4. Understand the biological properties of L. pneumophila
[Class hour: 1.5 hours ]
[Content]
1. intensively explain the biological characteristics, pathogenicity and immunity of Mycobacterium
2. intensively explain the principle, method, result judgement and significance of tuberculin test
3. detailed explain the biological characteristics, pathogenicity, immunity and treatment of C. dipheriae
4. explain the biological properties and pathogenesis of L. pneumophila

Chapter Spirochete（螺旋体）
[Requirement]
understand the characters, examination methods, prevention and treatment of spirochete（螺旋体）
Master the characteristics of spirochete（螺旋体）
[Class hour: 0.5 hours ]
[Content]
1. general explain general properties ,Classification of spirochete（螺旋体）
2. general explain Epidemiology, examination methods, prevention and treatment, Pathogenicity and immunity diagnosis of Treponema(密螺旋体), Borrelia（疏螺旋体）, Leptospira（钩端螺旋体）
3. detailed explain Pathogenicity of spirochete（螺旋体）

Chapter Mycoplasma（支原体）
[Requirement]
understand the characters,examination methods, prevention and treatment of mycoplasma(支原体)
Master pathogenesis of pathogenic mycoplasma
[Class hour: 0.5hours ]
[Content]
1. general explain common properties , examination methods, prevention and treatment of mycoplasma(支原体)
2. general explain Epidemiology, and pathogenesis and immunity of mycoplasma(支原体)

Chapter Rickettsia（立克次体）
[Requirement]
understand the characters, examination methods, prevention and treatment of Rickettsia（立克次体）
Master the pathogenic Rickettsia（立克次体）
[Class hour: 0.5hours ]
[Content]
1. general explain common properties of Rickettsia（立克次体）
2. general explain Epidemiology, pathogenesis and pathogenesis and immunity , examination methods, prevention and treatment of Rickettsia（立克次体）

Chapter Chlamydiae(衣原体)
[Requirement]
understand the characters, examination methods, prevention and treatment of chlamydiae(衣原体)
Master the characteristics of chlamydiae(衣原体)
[Class hour: 0.5 hours ]
[Content]
1. general explain general properties of chlamydiae(衣原体)
2. general explain Epidemiology, examination methods, prevention and treatment, Pathogenicity and immunity of chlamydiae(衣原体)

Chapter Respiratory viruses
[Requirement]
Master all of the common properties of Influenza viruses
Master the common properties, pathogenesis of SARS coronavirus
Understand the clinical illnesses caused by other respiratory viruses.
[Class hour: 3 hour ]
[Content]
1. detailed explain Characteristic properties of common respiratory viruses
2. intensively explain the pathogenesis of respiratory viruses,Influenza virus,Parainfluenza virus,Measles virus, Mumps virus,Rubella Virus.
3. general introduce the examination methods , prevention and Treatment of respiratory viruses infection.
4. intensively explain the common properties, pathogenesis of SARS coronavirus

Chapter Enterovirus
Diarrheal Virus
[Requirement]
Master the common properties of enteroviruses.
Master the pathogenesis of poliovirus.
Master the clinical illnesses caused by Coxackie virus, ECHO virus and New enteroviruses.
Master the biological properties and pathogenesis of rotaviruses.
[Class hour: 2 hour ]
[Content]
1. detailed explain Characteristic properties of common enteroviruses and rotaviruses.
2. intensively explain the pathogenesis and immunity of polioviruses and rotaviruses..
3. general introduce the the pathogenesis of Coxackie virus, ECHO virus and New enteroviruses.
4. general introduce the examination methods , prevention and treatment of enteroviruses and rotaviruses infection.

Chapter hepatitis virus
[Requirement]
Master the classification, transmission， examination methods and properties of hepatitis virus.
Master the pathogenesis and immunity of HAV,HBV,HCV and HEV..
Understand the pathogenesis immunity and examination methods of HDV and other hepatitis viruses.
[Class hour: 3 hour ]
[Content]
1. detailed explain the classification, transmission ，examination methods and properties of hepatitis virus(esp construction of HBV genome，Ag)
2. intensively explain the pathogenesis and immunity of HAV,HBV,HCV and HEV.
3. general introduce the pathogenesis immunity and examination methods of HDV and other hepatitis viruses.

Chapter Flavivirus and Hemorrhagic Fever Virus

[Requirement]
understand the common properties of Flavivirus .
Master the transmission ,pathogenesis, immunity ,prevention, treatments and o