杀菌剂毒理学复习.pptx

,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,#,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,#,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,#,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,#,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,#,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,#,杀菌剂毒理学复习,杀菌剂毒理学复习,第1页,2,杀菌剂发展,1,、第一代杀菌剂（,inorganic chemicals,）,;,2,、第二代杀菌剂（,organic chemicals,）,传统保护剂,(conventional protectants),植物药害,(phytotoxicity),；,3,、第三代杀菌剂：内吸性杀菌剂（,systemic fungicide,）,4,、第四代杀菌剂：三环唑等较早使用无杀菌毒性化合物。,杀菌剂毒理学复习,第2页,3,Classification according to action,保护型杀菌剂,protective fungicide,铲除性杀菌剂,eradication fungicide,治疗性杀菌剂,curative fungicide,内吸性杀菌剂,systemic fungicide,杀菌剂毒理学复习,第3页,4,Fungicide Toxicology,杀菌作用,(fungitoxicity),抑菌作用,(fungistasis),内吸性杀菌剂,(systemic fungicides,systemics),抗产孢剂,(antisporulants),杀菌剂毒理学复习,第4页,5,内吸性杀菌剂（,systemic fungicide,）,选择性,(selectivity),(1),靶标位点,(target site),和作用位点,(site of action),(2),靶标受体,(receptor),对药剂亲协力,(affinity),差异,(3),药剂对原生质膜渗透性,(permeability),差异,(4),对杀菌剂积累,(,或排出,),、解毒,(detoxify),作用差异等,杀菌剂毒理学复习,第5页,6,Mechanisms of Fungicide Action,Biosynthesis:Sterol,Nucleic acid,protein,mitosis and cell division,lipid,glucan(,葡聚糖,),cell wall,Respiration:Electron transport,oxidative phosphorylation,Growth regulator:cell wall biosynthesis-inhibiting oomyceticides,Structure,杀菌剂毒理学复习,第6页,7,1:Nucleic acids synthesis,(1)RNA polymerase I,PhenylAmides,苯酰胺类,:,Metalaxyl,甲霜灵,杀菌剂毒理学复习,第7页,8,2:Mitosis and cell division,(1),-tubulin assembly in mitosis,Benzimidazole:,Carbendazim,多菌灵,Diethofencarb,乙霉威,Negative cross resistance to Diethofencarb,乙霉威,杀菌剂毒理学复习,第8页,9,Respiration,(1)Complex I NADH Oxidoreductase:Pyrimidinamine,(2)Complex II:succinate-dehydrogenase,琥珀酸脱氢酶,SDHI(Succianate dehydrogenase inhibitor),Boscalid:,啶酰菌胺,杀菌剂毒理学复习,第9页,10,Respiration,(3)Complex III:cytochrome bc1(ubiquinol,辅酶,oxidase at Qo site(cyt b),Qol(Quinone outside Inhibitors),Azoxystrobin,嘧菌酯,kresoxim-methyl,醚菌酯,杀菌剂毒理学复习,第10页,