水通道蛋白4抗体在视神经脊髓炎发病机制中的作用.pdf

水通道蛋白4 抗体在视神经脊髓炎 发病机制中的作用武雷黄德晖吴卫平 摘要：视神经脊髓炎(N M O)是主要累及视神经和脊髓的中枢神经系统自身免疫性脱髓鞘疾病，既往在其与多发性硬化的关系上一直存有争议，水通道蛋白4(A Q P 4)抗体的发现，不但为N M O 是独立于M S 的疾病实体提供了新 的证据支持，而且把N M O 的研究推上了一个新的水平。该文就A Q P 4 抗体在N M O 发病机制中的作用，包括介导星形胶质细胞损伤、血-脑脊液屏障破坏、炎性反应细胞浸润、少突胶质细胞损伤和髓鞘破坏等方面进行综述。视神经脊髓炎；水通道蛋白4 抗体；星形胶质细胞R 7 4 4.5+2A1 0 0 6-2 9 6 3 (2 0 1 1)0 6-0 4 3 1-0 41 0.3 9 6 9/j.i s s n.1 0 0 6-2 9 6 3.2 0 1 1.0 6.0 1 41 0 0 8 5 3 解放军总医院神经内科万方数据4 3 2 万方数据 4 3 3 万方数据 1 d e S e z e J,L e b r u n C,S t o j k o v i c T,e t a l.I s D e v i c s n e u r o m y e l i t i s o p t i c a a s e p a r a t e d i s e a s e?A c o m p a r a t i v e s t u d y w i t h m u l t i p l e s c l e r o s i s J .M u l t S c l e r,2 0 0 3,9:5 2 1-5 2 5.2 G a l e t t a S L,B e n n e t t J.N e u r o m y e l i t i s o p t i c a i s a v a r i a n t o f m u l t i p l e s c l e r o s i s J .A r c h N e u r o l,2 0 0 7,6 4(6):9 0 1-9 0 3.3 M i s u T,F u j i h a r a K,K a k i t a A,e t a l.L o s s o f a q u a p o r i n 4 i n l e s i o n s o f n e u r o m y e l i t i s o p t i c a:d i s t i n c t i o n f r o m m u l t i p l e s c l e r o s i s J .B r a i n,2 0 0 7,1 3 0 :1 2 2 4-1 2 3 4.4 L e n n o n V A,W i n g e r c h u k D M,K r y z e r T J ,e t a l.A s e r u m a u t o a n t i b o d y m a r k e r o f n e u r o m y e l i t i s o p t i c a:d i s t i n c t i o n f r o m m u l t i p l e s c l e r o s i s J .L a n c e t,2 0 0 4,3 6 4 :2 1 0 6-2 1 1 2.5 L e n n o n V A,K r y z e r T J ,P i t t o c k S J ,e t a l.l g G m a r k e r o f o p t i c s p i n a l m u l t i p l e s c l e r o s i s b i n d s t o t h e a q u a p o r i n-4 w a t e r c h a n n e l J .J E x p M e d,2 0 0 5,2 0 2:4 7 3-4 7 7.6 A m i r y-M o g h a d d a m M,F r y d e n l u n d D S,O t t e r s e n O P.A n c h o r i n g o f a q u a p o r i n-4 i n b r a i n:M o l e c u l a r m e c h a n i s m s a n d i m p l i c a t i o n s f o r t h e p h y s i o l o g y a n d p a t h o p h y s i o l o g y o f w a t e r t r a n s p o r t J .N e u r o s c i e n c e,2 0 0 4,1 2 9 :9 9 9-1 0 1 0.7 S a i n i H,F e r n a n d e z G,K e r r D,e t a l.D i f f e r e n t i a l e x p r e s s i o n o f a q u a p o r i n-4 i s o f o r m s l o c a l i z e s w i t h n e u r o m y e l i t i s o p t i c a d i s e a s e a c t i v i t y J .J N e u r o i m m u n o l,2 0 1 0,2 2 1.6 8-7 2.8 R o s s i A,P i s a n i F,N i c c h i a G P,e t a l.E v i d e n c e s f o r a l e a k y s c a n n i n g m e c h a n i s m f o r t h e s y n t h e s i s o f t h e s h o r t e r M 2 3 p r o t e i n i s o f o r m o f a q u a p o r i n-4 :i m p l i c a t i o n i n o r t h o g o n a l a r r a y f o r m a t i o n a n d n e u r o m y e l i t i s o p t i c a a n t i b o d y i n t e r a c t i o n J .J B i o l C h e m,2 0 1 0,2 8 5:4 5 6 2-4 5 6 9.9 N i c c h i a G P,M a s t r o t o t a r o M,R o s s i A,e t a l.A q u a p o r i n-4 o r t h o g o n a l a r r a y s o f p a r t i c l e s a r e t h e t a r g e t f o r n e u r o m y e l i t i s o p t i c a a u t o a n t i h o d i e s J .G l i a,2 0 0 9,5 7 :1 3 6 3-1 3 7 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u a X,e t a l.A l t e r e d b l o o d-b r a i n b a r r i e r i n t e g r i t y i n a d u l t a q u a p o r i n-4 k n o c k o u t m i c e J .N e u r o r e p o r t,2 0 0 8,1 9:1-5.1 8 S a i k a l i P,C a y r o l R,V i n c e n t T.A n t i-a q u a p o r i n-4 a u t o-a n t i b o d i e s o r c h e s t r a t e t h e p a t h o g e n e s i s i n n e u r o m y e l i t i s o p t i c a J .A u t o i m m u n R e v,2 0 0 9,9:1 3 2-1 3 5.1 9 P i t t D,W e r n e r P,R a i n e C S.G l u t a m a t e e x c i t o t o x i c i t y i n a m o d e l o f m u l t i p l e s c l e r o s i s J .N a t M e d,2 0 0 0,6:6 7-7 0.2 0 M a t u t e C,D o m e r c q M,S n c h e z-G m e z M V.G l u t a m a t e-m e d i a t e d g l i a l i n j u r y:m e c h a n i s m s a n d c l i n i c a l i m p o r t a n c e J .G l i a,2 0 0 6,5 3 :2 1 2-2 2 4.2 1 M a r i g n i e r R,N i c o l l e A,W a t r i n C,e t a l.O l i g o d e n d r o c y t e s a r e d a m a g e d b y n e u r o m y e l i t i s o p t i c a i m m u n o g l o b u l i n G 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p l e m e n t p r o d u c e s n e u r o m y e l i t i s o p t i c a l e s i o n s i n m i c e J .B r a i n,2 0 1 0,1 3 3:3 4 9-3 6 1.2 6 K i n o s h i t a M,N a k a t s u j i Y,K i m u r a T,e t a l.A n t i-a q u a p o r i n 4 a n t i b o d y i n d u c e s a s t r o c y t i c c y t o t o x i c i t y i n t h e a b s e n c e o f C N S a n t i g e n-s p e c i f i c T c e l l s J .B i o c h e m B i o p h y s R e s C o m m u n,2 0 1 0,3 9 4 :2 0 5-2 1 0.2 0 1 1-0 3-0 4万方数据水通道蛋白4抗体在视神经脊髓炎发病机制中的作用水通道蛋白4抗体在视神经脊髓炎发病机制中的作用作者：武雷，黄德晖，吴卫平作者单位：100853,解放军总医院神经内科刊名：中国神经免疫学和神经病学杂志英文刊名：Chinese Journal of Neuroimmunology and Neurology年，卷(期)：2011,18(6)参考文献(26条)参考文献(26条)1.Amiry-Moghaddam M;Frydenlund DS;Ottersen OP Anchoring of aquaporin-4 in brain:Molecular mechanisms andimplications for the physiology and pathophysiology of water transport 20042.Lennon VA;Kryzer TJ;Pittock SJ lgG marker of opticspinal multiple sclerosis binds to the aquaporin-4 water channel外文期刊 20053.Lennon VA;Wingerchuk DM;Kryzer TJ A 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