生物信息学分析方法.ppt

单击此处编辑母版标题样式,编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,常用的生物信息学,分析方法,第十组,1,生物信息学是一门在生命科学的研究中，以计算机为工具对生物信息进行储存、检索和分析的科学。,生物信息学,Bioinformatics,生物信息学基本上是,分子生物学,与,信息技术,的结合体。,研究材料和结果,是各种各样的生物学数据,研究工具,是计算机,研究方法,包括对生物学数据的搜索（收集和筛选）、处理（编辑、整理、管理和显示）及利用（计算、模拟）,2,节律基因,Timeless,3,数据库,MGI,www.informatics.jax.org/,4,数据库,NCBI,https:/blast.ncbi.nlm.nih.gov/Blast.cgi,5,数据库,TAIR,www.arabidopsis.org/,6,promoter element,CAAT-box,260,CCAAT,common cis-acting element in promoter and enhancer regions,3-AF1 binding site,50,AAGAGATATTT,light responsive element,CCAAT-box,1051,CAACGG,MYBHv1 binding site,CGTCA-motif,1294,CGTCA,MeJA-responsiveness,GA-motif,1252,ATAGATAA,light responsive element,HSE,28,AAAAAATTTC,heat stress responsiveness,LTR,414,CCGAAA,low-temperature responsiveness,MSA-like,568,CCCAACGGT,cell cycle regulation,TGA-element,289,AACGAC,auxin-responsive element,11,ID,Name,Score,Relative score,Start,End,Strand,Predicted sequence,MA0940.1,AP1,12.57,0.901,16,28,+,acaaaaatgaaat,MA0934.1,AHL25,12.5169,1,328,335,+,aattaatt,MA0951.1,ATHB-16,12.2423,0.964,352,359,+,taatgatt,MA0933.1,AHL20,12.006,0.979,328,335,+,aattaatt,MA0943.1,ARF5,11.8449,0.974,1017,1024,+,GCCGACAG,MA0947.1,ARR14,11.8132,0.965,707,714,+,AGATCCGC,MA0934.1,AHL25,11.8126,0.984,333,340,+,atttaatt,12,bar.utoronto.ca/,可视化基因组学,BAR,13,suba.live,亚细胞定位,SUBA,AGI,SUBAcon,Predictions,AT5G52910.1,nucleus,nucleuscytosolmitochondrion,14,www.sbg.bio.ic.ac.uk/phyre/,三级结构预测,Phyre,16-464 replication,643-747 protein binding,15,www.cbs.dtu.dk/services/SignalP/,信号肽预测,SignalP,AT5G52910,AT1G01070,16,www.cbs.dtu.dk/services/TMHMM-2.0/,跨膜结构域预测,TMHMM,17,string.embl.de,蛋白互作网络,STRING,DNA repair,polymerase,helicase,18,序列分析,双序列比对,MEGA-,ReadingFrame),分析,NBCI-,https:/www.ncbi.nlm.nih.gov/orffinder/,基因结构分析（外显子、内含子）,GSDS-,-,genemania.org/,BIND-,bind.ca/,IntAct-,www.ebi.ac.uk/intact/,DIP-,dip.doe-mbi.ucla.edu/,19,谢谢,20,