胶质母细胞瘤解析.ppt

,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,*,单击此处编辑母版标题样式,Case report,Xian central hospital,Dang shan,New words,somnolentia smnlenr 嗜睡,morphology m:rf:ldi 形态学,paediatric pi:dtrk 儿科的,hydrocephalushadrsefls 脑积水,heterogeneous 成分混杂的,cauliflower 菜花,neuroepithelial,神经上皮的,prognosis 预后,infiltrate 浸润 渗透,Medical history,2-year-old male patient,Somnolentia,decrease consciousness 3,hours,A Ependymoma,B Choroid plexus papilloma,C Intraventricular meningioma,D Glioblastoma,What is your diagnosis?,Pathological result,Lateral ventricle glioblastoma,Immunohistochemistry:GFAP+、S-100+、Vim+、Syn part+、Ki67 40%、Olig-2 few、CD99-/+、NeuN-CK-、EMA-,Glioblastoma,Incidence：Glioblastoma accounts for about,57%of all brain tumors in children,Peak age：4555 years old,less occur at age lower than,30-year-old,Location:Supratentorial white matter most,common,especially in frontal and,temporal lobes.,Morphology:Poorly-marginated,diffusely-infiltrating necrotic mass.Tumor typically acrosses white matter tracts to involve contralateral hemisphere,Prognosis:Poor,1year survival rate is only about 50%,NECT Finding：Irregular isodense or hypodense mass with central hypodensity representing necrosis.Marked mass effect and surrouding edema,tumor infiltration，hemorrage not uncommon，calcification rare,CECT Finding：95%have stong,heterogeneous,irregular rim-enhancement,T1WI irregular isotense,hypointense,white matter mass,T2WI heterogeneous,hypointense mass,with adjacent tumor infiltration and,edema,DWI no typically diffusion restriction,necrosis,cysts,hemorrage may be seen,MR Finding,Ependymoma,Peak age:before the age of 5 years old,Location:about 8%occured in the lateral ventricle,Morphology：typically heterogeneous mass,with areas,of necrosis,calcification,cystic change,and frequent hemorrhage,MR Finding：,T1WI isointense to hypointense relative to white matter,T2WI hyperintense to white matter,T1C+(Gd)enhancement present but heterogeneous,DWI diffusion restrict may be seen in solid components,CT Ependymoma,MR Ependymoma,An uncommon,benign neuroepithelial intraventricular tumour which can occur in both the paediatric and adult.,lobulated or cauliflower-like masses,hydrocephalus common,CT iso-or somewhat hyperdense，,homogeneous enhancement,T1WI typically isointense or somewhat hypointense,T2WI iso to hyperintense,T1 C+(Gd)marked enhancement,tends to be,homogenous,Choroid plexus papilloma,T2WI T1WI,T1C+Choroid plexus papilloma,Intraventricular meningioma,Location:80%trigone of lateral ventricle,15%,the third ventricle,5%the fourth ventricle,CT 60%slightly hyperdense to normal brain,20-,30%have some calcification,72%brightly and,homogenously contrast enhance,less,frequent in malignant or cystic variants,T1WI isointense or somewhat hypointense compared to,grey matter,T2WI isointense,hyperintense or hypointense,compared to grey matter,T1 C+(Gd)usually homogenous enhancement,T1WI,Intraventricular meningioma,T2WI T1+C,Thank you!,